Results 71 to 80 of about 4,015,701 (290)
Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]
, 2017 Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín +1 more
core +1 more source
HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis [PDF]
Immunity, 2018 Recognition of cytoplasmic lipopolysaccharide (LPS) by caspase-11 leads to pyroptosis and secretion of inflammatory mediators. In this issue of Immunity, Deng et al. (2018) report that high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into the cytoplasm and mediates pyroptosis.
Ho Min, Kim, You-Me, Kim
openaire +2 more sources
Pathogens, 2020 Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson +13 more
doaj +1 more source
Frontiers in Immunology, 2021 Non-canonical inflammasome activation by mouse caspase-11 (or human CASPASE-4/5) is crucial for the clearance of certain gram-negative bacterial infections, but can lead to severe inflammatory damage.
Debabrata Chowdhury +9 more
doaj +1 more source
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
Listeria monocytogenesInfection in Caspase-11-Deficient Mice [PDF]
Infection and Immunity, 2002 ABSTRACTCaspase-11 (Cas11) is a cysteine protease involved in programmed cell death and cytokine maturation. Through activation of Cas1 (interleukin-1β [IL-1β]-converting enzyme), Cas11 is directly involved in the maturation of IL-1β and IL-18. Apoptosis is mediated through Cas3.
Mueller, Nicholas J. +2 more
openaire +3 more sources
Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]
, 2018 Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M. +5 more
core +1 more source
Caspase-11 Modulates Inflammation and AttenuatesToxoplasma gondiiPathogenesis [PDF]
Mediators of Inflammation, 2016 Toxoplasma gondiiis an obligate intracellular parasite that is the etiologic agent responsible for toxoplasmosis. Infection withT. gondiiresults in activation of nucleotide binding domain and leucine rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL ...
Coutermarsh-Ott, Sheryl +5 more
openaire +3 more sources
mBio, 2019 Chlamydia trachomatis is the most common bacterial cause of sexually transmitted infections. C. trachomatis sexually transmitted infections are commonly asymptomatic, implying a pathogenic strategy for the evasion of innate inflammatory immune responses,
Chunfu Yang +7 more
doaj +1 more source
Inflammatory caspases : key regulators of inflammation and cell death [PDF]
, 2014 The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel +1 more
core +2 more sources