Results 81 to 90 of about 4,015,701 (290)

Protective Role for Caspase-11 during Acute Experimental Murine Colitis [PDF]

The Journal of Immunology, 2015
Abstract Activation of the noncanonical inflammasome, mediated by caspase-11, serves as an additional pathway for the production of the proinflammatory cytokines IL-1β and IL-18. Noncanonical inflammasome activity occurs during host defense against Gram-negative bacteria and in models of acute septic shock.
Oficjalska K., Raverdeau M., Aviello G., Wade S. C., Hickey A., Sheehan K. M., Corr S. C., Kay E. W., O'Neill L. A., Mills K. H. G., Creagh E. M.   +10 more
openaire   +5 more sources

Inflammasome priming in sterile inflammatory disease [PDF]

, 2017
The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must occur
Bryant, Clare E., Carroll, Richard G., Galván-Peña, Silvia, Masters, Seth L., Mills, Evanna L., Olden, Robin, Patel, Meghana N., Triantafilou, Kathy, Triantafilou, Martha, Wolf, Amaya I.   +9 more
core   +2 more sources

Caspase-11 Protects Against Bacteria That Escape the Vacuole [PDF]

Science, 2013
Caspase-11–Dependent Pyroptosis Inflammasomes are multiprotein complexes that assemble to initiate immunity to a variety of microorganisms, as well as to sterile tissue injury. Although a role for caspase-1 downstream of inflammasomes is well characterized, the discovery that caspase-1 knockout mice were also deficient in caspase-
Youssef, Aachoui, Irina A, Leaf, Jon A, Hagar, Mary F, Fontana, Cristine G, Campos, Daniel E, Zak, Michael H, Tan, Peggy A, Cotter, Russell E, Vance, Alan, Aderem, Edward A, Miao   +10 more
openaire   +2 more sources

Inflammatory caspase substrate specificities

mBio
Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes such as programmed cell death and inflammation.
Patrick M. Exconde, Christopher M. Bourne, Madhura Kulkarni, Bohdana M. Discher, Cornelius Y. Taabazuing   +4 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling

Cell Death and Disease, 2022
Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients.
Chuang Yuan, K. Ai, Menghua Xiang, Cheng-Liang Xie, Ming-Liang Zhao, Ming Wu, Hongli Li, Yueren Wu, Yue-Qi Cao, Can Li, Yanjun Zhong, X. Pei, Helene Law, Liqian Gao, Qicai Xiao, Xinyu Yang   +15 more
semanticscholar   +1 more source

Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis

EMBO Molecular Medicine, 2019
Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11 is modulated remains ...
Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee   +9 more
doaj   +1 more source

Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated PyroptosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background: Pyroptosis, gasdermin-mediated programmed cell death, is readily induced in macrophages by activation of the canonical inflammasome (caspase-1) or by intracellular lipopolysaccharide (LPS)-mediated non-canonical inflammasome (caspase-11 ...
Ping Sun, Jie Zhong, Hong Liao, Patricia Loughran, Joud Mulla, Guang Fu, Da Tang, Jie Fan, Timothy R. Billiar, Wentao Gao, Melanie J. Scott   +10 more
doaj   +1 more source

The Inflammatory Response to Enterotoxigenic E. coli and Probiotic E. faecium in a Coculture Model of Porcine Intestinal Epithelial and Dendritic Cells [PDF]

, 2018
The gut epithelium constitutes an interface between the intestinal contents and the underlying gut-associated lymphoid tissue (GALT) including dendritic cells (DC).
Aschenbach, Jörg R., Ebner, Friederike, Lodemann, Ulrike, Loss, Henriette, Tedin, Karsten   +4 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source