Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation [PDF]
PLoS ONE, 2017 IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.
Stephanie Zwicker +2 more
exaly +9 more sources
Caspase-5: Structure, Pro-Inflammatory Activity and Evolution [PDF]
BiomoleculesCaspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS), a component of the cell envelope of Gram-negative bacteria. The expression level of the CASP5 gene is very low in the basal state, but strongly increases in the ...
Leopold Eckhart, Heinz Fischer
exaly +7 more sources
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage [PDF]
Frontiers in Immunology, 2023 The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections to carry out pyroptosis.
Mohamed Ghait +15 more
doaj +6 more sources
TLR2/caspase-5/Panx1 pathway mediates necrosis-induced NLRP3 inflammasome activation in macrophages during acute kidney injury [PDF]
Cell Death Discovery, 2022 Acute kidney injury (AKI) is characterized by necroinflammation formed by necrotic tubular epithelial cells (TECs) and interstitial inflammation. In necroinflammation, macrophages are key inflammatory cells and can be activated and polarized into ...
Jun Wang
exaly +6 more sources
Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis [PDF]
Bioengineered, 2022 Circular RNA (circRNA) plays a regulatory role in periodontitis. This study explored whether circ_0138959 affected lipopolysaccharide (LPS)-induced pyroptosis in human gingival fibroblasts (HGFs).
Pan J, Zhao L, Liu J, Wang G.
exaly +6 more sources
SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade. [PDF]
EMBO J, 2021 Altered intestinal microbial composition promotes intestinal barrier dysfunction and triggers the initiation and recurrence of inflammatory bowel disease (IBD).
Wang X +13 more
europepmc +4 more sources
Nature Communications, 2015 Monocytes promote the early host response to infection releasing key pro-inflammatory cytokines, such as IL-1β. The biologically inactive IL-1β precursor is processed to active form by inflammasomes, multi-protein complexes activating caspase-1.
Roberto Spreafico, Alessandra Mortellaro
exaly +4 more sources
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]
Nature Communications, 2016 Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E +7 more
core +2 more sources
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Cell Discovery, 2020 Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two.
Timur Liwinski, Eran Elinav
exaly +2 more sources
MedCommNoncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of pyroptosis in SLE pathogenesis remains unclear ...
Yue Xin +4 more
doaj +2 more sources