Results 101 to 110 of about 11,510,202 (303)

Loss of expression of the tumor suppressor CEACAM1 links different hereditary colorectal carcinoma sub-types to the genesis of sporadic colorectal carcinoma [PDF]

, 2012
According to their carcinogenesis, colorectal cancer (CRC) subtypes show distinct molecular parameters. Hereditary non-polypous colorectal cancer (HNPCC) is the most common inherited CRC characterized by clinical criteria and confirmed microsatellite ...
Neumaier, Christian, Neumaier, Michael, Nittka, Stefanie   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Caspase-8 activation regulates enterovirus D68 infection-induced inflammatory response and cell death

Biosafety and Health
Enterovirus D68 (EV-D68) infection causes severe acute respiratory infection and severe neurological complications, such as acute flaccid myelitis (AFM), in children.
Yuanyuan Zhou, Chongtao Zhang, Yuhan Zhang, Fei Li, Jun Shen   +4 more
doaj   +1 more source

Activation of caspase-9 and its influencing factors in beef during conditioning

Animal, 2014
To study the activation of caspase-9 and its potential influence in conditioning, longissimus thoracis (LT), semitendinosus (STN) and psoas minor (PMi) muscles were used to analyze the ratio of pro-apoptotic bax to anti-apoptotic bcl-2 in fresh tissues ...
J. Cao, G. Zhou, Y. Liu, G. Liao, Q. Zhang, K. Ye, D. Pan, C. Ou   +7 more
doaj   +1 more source

NALP1 is a transcriptional target for cAMP-response-element-binding protein (CREB) in myeloid leukaemia cells [PDF]

, 2004
NALP1 (also called DEFCAP, NAC, CARD7) has been shown to play a central role in the activation of inflammatory caspases and processing of pro-IL1β (pro-interleukin-1β).
Andreu, E.J. (Enrique José), Calasanz-Abinzano, M.J. (Maria Jose), Fernandez-Luna, J.L. (J.L.), Prosper, F. (Felipe), Richard, C. (Carlos), Sanz, C. (C.)   +5 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review. [PDF]

, 2009
Colorectal cancer is a leading cause of cancer related mortality in the Western world. In recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment of this disease has led to improved disease free and overall survival ...
Abdel-Rahman, Abdel-Rahman, Ahn, Albeck, Alizadeh, Altieri, Ambrosini, An, Andre, Backus, Backus, Barczyk, Baretton, Bedi, Belluco, Benson, Bezulier, Bhatavdekar, Biden, Boise, Borner, Bosari, Boyer, Buglioni, Buglioni, Cande, Carethers, Chan, Contu, Dalerba, Datta, Dean, Deveraux, Diallo, DiPaola, Dohi, Fan, Garrity, Gibson, Goldberg, Graziano, Griffith, Griffiths, Gross, Gryfe, Han, Han, Haupt, Hector, Hilska, Hockenbery, Hoffmann, Houston, Hua, Huber, Igney, Ionov, Irmler, Jansson, Jansson, Jeong, Jochen H.M. Prehn, Johnston, Jover, Kandasamy, Kawasaki, Khor, Kim, Kim, Kim, Klionsky, Kondo, Koornstra, Kozopas, Krajewska, Krajewska, Krajewska, Krajewska, Kushlinskii, Lakhani, Lee, Lee, Leonardos, Letai, Li, Li, Lindsten, Linette, Liu, Luo, Ma, Manne, Meterissian, Metzger, Michael-Robinson, Mild, Miquel, Morris, Nadal, Nakano, Nehls, Nehls, Nozoe, O'Brien, O'Connell, O'Connell, O'Reilly, Oda, Ogura, Oren, Palmerini, Paradiso, Petersen, Pitti, Ponnelle, Putt, Rampino, Rehm, Restifo, Ricci-Vitiani, Ricci-Vitiani, Rohayem, Roy, Ryu, Saeki, Sakamoto, Saltz, Sarela, Sarela, Schimmer, Schwandner, Schwartz, Sheehan, Shintani, Shirota, Shmelkov, Silke, Sinicrope, Sinicrope, Sinicrope, Sinicrope, Sinicrope, Sjo, Soengas, Soung, Soung, Strater, Sturm, Susin, Suzanne Hector, Tillman, Tornillo, Trojan, Tsuji, Ullenhag, Urbano, van der Woude, van der Woude, van Geelen, van Triest, Varma, Vaux, Violette, Visca, Walker, Wang, Watson, Wei, Wiley, Wilson, Wilson, Wolter, Yang, Yang, Yoo, Yu, Yu, Yue, Zha, Zhou, Zlobec, Zlobec, Zou   +182 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Immune genes undergo more adaptive evolution than non-immune system genes in Daphnia pulex [PDF]

, 2012
Background Understanding which parts of the genome have been most influenced by adaptive evolution remains an unsolved puzzle. Some evidence suggests that selection has the greatest impact on regions of the genome that interact with other evolving ...
Conlon, Claire, Little, Thomas, McTaggart, Seanna J, Obbard, Darren J   +3 more
core   +2 more sources

Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes

Cell Death and Disease, 2015
The human inflammatory caspases, including caspase-1, -4, -5 and -12, are considered as key regulators of innate immunity protecting from sepsis and numerous inflammatory diseases.
MG Sanders, M. Parsons, Aga Howard, J. Liu, SR Fassio, JA Martinez, L. Bouchier-Hayes   +6 more
semanticscholar   +1 more source