Results 11 to 20 of about 11,510,202 (303)
Identification of specific tethered inhibitors for caspase-5. [PDF]
Chem Biol Drug Des, 2012 The development of highly selective small molecule inhibitors for individual caspases, a class of cysteine‐dependent aspartate‐specific proteases, has been challenging due to conservation of the active site. Previously, we discovered an allosteric site at the dimer interface of caspases‐3, ‐7, and ‐1 using disulfide trapping.
Gao J, Wells JA.
europepmc +5 more sources
European Journal of Immunology, 2015 Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and caspase‐5. When activated, these trigger pyroptotic cell death and caspase‐1‐dependent IL‐1β production; however the mechanism underlying this process is not yet confirmed.
Paul J Baker +2 more
exaly +5 more sources
Biochemical Journal, 2001 Max is the central component of the Myc/Max/Mad network of transcription factors that regulate growth, differentiation and apoptosis. Whereas the Myc and Mad genes and proteins are highly regulated, Max expression is constitutive and no post-translational regulation is known. We have found that Max is targeted during Fas-induced apoptosis. Max is first
Bernhard Lüscher
exaly +6 more sources
Concerted Antigen Processing of a Short Viral Antigen by Human Caspase-5 and -10* [PDF]
Journal of Biological Chemistry, 2011 The generation of peptides presented by MHC class I molecules requires the proteolytic activity of the proteasome and/or other peptidases. The processing of a short vaccinia virus-encoded antigen can take place by a proteasome-independent pathway ...
Daniel López +3 more
semanticscholar +5 more sources
Immunology & Cell Biology, 2018 Outer membrane vesicles (OMVs) are constitutively produced by Gram‐negative bacteria both in vivo and in vitro. These lipid‐bound structures carry a range of immunogenic components derived from the parent cell, which are transported into host target ...
Natalie J. Bitto +10 more
semanticscholar +5 more sources
SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest. [PDF]
EMBO J, 2021 Endosomes are important cellular compartments for sorting internalized cargo and immune sensing. In this issue, Wang et al describe a novel signaling pathway induced by endocytosed bacterial outer membrane vesicles, where sorting nexin 10 and caspase-5 act at the endosome to promote cytosolic exposure of LPS and initiate signaling to alter epithelial ...
Dickinson MS, Coers J.
europepmc +3 more sources
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death. [PDF]
J Immunol, 2021 Abstract Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in the inflammatory activation of monocytes, macrophages, and the endothelium.
Bolívar BE +8 more
europepmc +4 more sources
Caspase-5 expression is upregulated in lesional psoriatic skin. [PDF]
Journal of Investigative Dermatology, 2011 The inflammasome is a cytosolic multiprotein complex with two major functions: recognizing pathogen-associated molecular patterns and reacting to these through activation of the proinflammatory cytokines IL-1β and IL-18. In this study, we characterized the expression of inflammasome components in psoriatic skin and other common inflammatory skin ...
M. Salskov-Iversen +3 more
semanticscholar +4 more sources
Caspase 5 depletion is linked to hyper-inflammatory response and progeroid syndrome. [PDF]
Geroscience, 2023 AbstractA progeroid family was found to harbor a pathogenic variant in the CASP5 gene that encodes inflammatory caspase 5. Caspase 5-depleted fibroblasts exhibited hyper-activation of inflammatory cytokines in response to pro-inflammatory stimuli. Long-term intermittent hyper-inflammatory response is likely the cause of the accelerated aging phenotype ...
Hisama FM +6 more
europepmc +3 more sources