Results 21 to 30 of about 11,510,202 (303)

Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells. [PDF]

Investigative Opthalmology & Visual Science, 2011
To investigate the expression, activation, and functional involvement of caspase-5 in human retinal pigment epithelial (hRPE) cells.Expression and activation of caspase-5 in primary cultured hRPE cells, telomerase-immortalized hTERT-RPE1 cells (hTERT-RPE1), or both, were measured after stimulation with proinflammatory agents IL-1β, TNF-α ...
Z. Bian, S. Elner, H. Khanna, C. Murga-Zamalloa, Suresh B. Patil, V. Elner   +5 more
semanticscholar   +3 more sources

Human adenovirus infection induces pulmonary inflammatory damage by triggering noncanonical inflammasomes activation and macrophage pyroptosis

Frontiers in Immunology, 2023
IntroductionHuman adenovirus (HAdV) is a common respiratory virus, which can lead to severe pneumonia in children and immunocompromised persons, and canonical inflammasomes are reported to be involved in anti-HAdV defense.
Lexi Li, Lexi Li, Huifeng Fan, Jinyu Zhou, Xuehua Xu, Diyuan Yang, Minhao Wu, Can Cao, Gen Lu, Gen Lu   +9 more
doaj   +1 more source

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease

Frontiers in Pharmacology, 2022
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production.
Aoife P. Smith, Emma M. Creagh
doaj   +1 more source

Inflammatory Caspase Activity Mediates HMGB1 Release and Differentiation in Myoblasts Affected by Peripheral Arterial Disease

Cells, 2022
Introduction: We previously showed that caspase-1 and -11, which are activated by inflammasomes, mediate recovery from muscle ischemia in mice. We hypothesized that similar to murine models, inflammatory caspases modulate myogenicity and inflammation in ...
Ricardo Ferrari, Bowen Xie, Edwyn Assaf, Kristin Morder, Melanie Scott, Hong Liao, Michael J. Calderon, Mark Ross, Patricia Loughran, Simon C. Watkins, Iraklis Pipinos, George Casale, Edith Tzeng, Ryan McEnaney, Ulka Sachdev   +14 more
doaj   +1 more source

SERPINB1-mediated checkpoint of inflammatory caspase activation

Nature Immunology, 2019
Youn Jung Choi, Stephanie Kim, Younho Choi   +2 more
exaly   +2 more sources

Anticancer Effect of Fluorouracil and Gum-Based Cerium Oxide Nanoparticles on Human Malignant Colon Carcinoma Cell Line (Caco2) [PDF]

Cell Journal, 2023
Objective: We investigated whether co-incubation of 5-FU and gum-based cerium oxide nanoparticles (CeO2 NPs) would improve half-maximal inhibitory concentration (IC50) and apoptosis in the Caco-2 cancer cell lineMaterials and Methods: In this ...
Zahra Keramati, Gholamreza Motalleb, Abbas Rahdar, Mohammad Amin Kerachian   +3 more
doaj   +1 more source

Increased expression of caspase 1 during active phase of connective tissue disease [PDF]

PeerJ, 2019
Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai, Qiongqiong Wang, Gongmin Zhu, Liying Zhu, Zhen Tao   +4 more
doaj   +2 more sources

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Journal of Neuroinflammation, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj   +1 more source

Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases [PDF]

Cell Death & Differentiation, 1997
Proteases of the caspase family are implicated in mammalian apoptosis and constitute a protease cascade. We characterized caspase-4 (TX/ICH-2/ICErelII) and caspase-5 (ICErelIII/TY), which are most closely related to caspase-1 (ICE) among the caspase family.
S. Kamada, Yoshimitsu Funahashi, Y. Tsujimoto   +2 more
semanticscholar   +3 more sources

Innate immunity to intracellular LPS

Nature Immunology, 2019
Yue Zhao, Shao Feng, Feng Shao
exaly   +2 more sources