Results 31 to 40 of about 11,510,202 (303)
ClC-5 Downregulation Induces Osteosarcoma Cell Apoptosis by Promoting Bax and tBid Complex Formation
Frontiers in Oncology, 2021 Osteosarcoma is the most common malignant bone tumor. Chloride (Cl−) channels-mediated Cl− movement plays an important role in regulating the functions of various cancer cells, but its role in osteosarcoma remains unclear.
Fei Peng +3 more
doaj +1 more source
Antitumor activity of flavonoids from hance on gastric cancer
European Journal of Inflammation, 2021 Introduction: To investigate antitumor activity and mechanism of flavonoids from Alpinia officinarum Hance against gastric cancer. Methods: Transplanted mouse fore-stomach carcinoma (MFC) tumor mice were divided into six groups: control group, model ...
Mirensha Yakufu +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background:Sophora flavescens aiton (SFA) and its main bioactive metabolite matrine are widely used in traditional Chinese medicine (TCM) preparations and have achieved good curative effects for the treatment of various tumors.
Huan-Fu Hu +8 more
doaj +1 more source
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death
Journal of Immunology, 2020 Key Points Heme induces oligomerization of caspase-1, caspase-4, and caspase-5. Heme-induced IL-1β release requires both caspase-4 and caspase-5. Caspase-4 is the primary effector of heme-induced cell death. Visual Abstract Excessive release of heme from
B. Bolívar +8 more
semanticscholar +1 more source
Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
doaj +1 more source
Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are Targets for Mutation in Microsatellite-Unstable Acute Leukemia/Myelodysplastic Syndrome [PDF]
Molecular Cancer Research, 2005 Abstract Microsatellite instability (MSI) in tumors is diagnostic for inactive DNA mismatch repair. It is widespread among some tumor types, such as colorectal or endometrial carcinoma, but is rarely found in leukemia. Therapy-related acute myeloid leukemia/myelodysplastic syndrome (tAML/MDS) is an exception, and MSI is frequent in tAML ...
J. Offman +12 more
semanticscholar +3 more sources
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential [PDF]
, 2015 Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis.
Caiazza, F +12 more
core +2 more sources
Mitochonic acid 5 regulates mitofusin 2 to protect microglia
Neural Regeneration Research, 2021 Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis.
Jian Tan +7 more
doaj +1 more source
Biomolecules, 2022 The study was to investigate the effect of canonical and noncanonical pyroptosis in apical periodontitis. Proteins’ profiles of human apical periodontitis tissue were analyzed by label-free proteomics.
Zhiwu Wu +7 more
doaj +1 more source