Results 81 to 90 of about 11,510,202 (303)

NALP1 in vitiligo-associated multiple autoimmune disease. [PDF]

, 2007
BACKGROUND: Autoimmune and autoinflammatory diseases involve interactions between genetic risk factors and environmental triggers. We searched for a gene on chromosome 17p13 that contributes to a group of epidemiologically associated autoimmune and ...
Bennett, DC, Fain, PR, Gowan, K, Jin, Y, LaBerge, G, Mailloux, CM, Riccardi, SL, Spritz, RA   +7 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

IMMUNOHISTOCHEMICAL ANALYSIS OF CASPASE-3 ACTIVITY IN LIVER BIOPSIES OF PATIENTS WITH MONO AND MIXED INFECTIONS

Klinicist, 2015
Objective: to study the activity of proapoptotic signal protein caspase-3 for determination of peculiarities of apoptosis regulation under liver chronic diseases.Subjects and methods.
I. I. Tokin, I. B. Tokin, T. V. Sologub, G. F. Filimonova, P. Hussar   +4 more
doaj   +3 more sources

Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection. [PDF]

, 2017
BACKGROUND: Most insights into the cascade of immune events after acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models.
Auffray, Charles, Bryant, Juliet E, Cao, Ngoc Huong, Dang, Thi Kim Huyen, de Jong, Menno, De Meulder, Bertrand, Do, Lien Anh Ha, Farrar, Jeremy, Hibberd, Martin L, Ho, Lu Viet, Hofstra, Jorrit-Jan, Le Binh, Bao Tinh, Ngo, Ngoc Quang Minh, Nguyen, Bach Hue, Nguyen, Huu Mai Khanh, Nguyen, Minh Tien, Nguyen, Thi Thanh Hai, Pellet, Johann, Thai, Quang Tung, Tran Dac, Nguyen Anh, Tran, Anh Tuan, Tran, Quynh Huong, Tran, Thi Thu Loan, Tran, Thu Van, Trinh, Hong Nhien, van Doorn, H Rogier, Vo, Quoc Bao, Vo, Thanh Vu   +27 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion

Cell Communication and Signaling, 2017
Background Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms have not been fully elucidated.
You-Take Oh, Ping Yue, Shi-Yong Sun
doaj   +1 more source

Identification and Characterization of Novel Caspase Inhibitors: The Unforeseen Effects of NSAIDs [PDF]

, 2016
Proper regulation of cell death and the inflammatory mechanism leading to cell death is vital for the development and homeostasis of living organisms. Dysregulation of cell death leads to cancer, neurodegenerative disorders, and inflammatory conditions ...
Soti, Subada
core   +2 more sources

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death [PDF]

, 2016
Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals.
Broz, Petr, Farady, Christopher J., Heilig, Rosalie, Hiller, Sebastian, Mulvihill, Estefania, Müller, Daniel J., Pipercevic, Joka, Rühl, Sebastian, Sborgi, Lorenzo, Stahlberg, Henning   +9 more
core   +1 more source

Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease

The FEBS Journal, 2019
Members of the mammalian inflammatory caspase family, including caspase‐1, caspase‐4, caspase‐5, caspase‐11, and caspase‐12, are key regulators of the innate immune response. Most studies to date have focused on the role of caspase‐1 in the maturation of
B. Bolívar, T. Vogel, L. Bouchier-Hayes
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source