Results 1 to 10 of about 279,199 (293)
Activation of the NLRP1B inflammasome by caspase-8 [PDF]
Communications BiologyCleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome.
Justin J. Meade +5 more
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Caspase 8: igniting the death machine [PDF]
Structure, 1999 Intense research into the signaling pathways of apoptosis has revealed a dominant role for proteases belonging to the caspase family, which in humans has 11 members at present. Two papers in the September issue of Structure with Folding & Design have for the first time revealed the structure of the key apoptotic initiator, caspase 8.
Guy S. Salvesen
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Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis [PDF]
Acta Dermato-Venereologica, 2023 is missing (Short communication)
Teresa Ju +10 more
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Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death [PDF]
Cell Death DiscoveryCaspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 (T265), which can inactivate caspase-8 for bypassing caspase-8 ...
Peng He +4 more
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A rare immunological disease, caspase 8 deficiency: case report and literature review [PDF]
Allergy, Asthma & Clinical Immunology, 2023 Background Caspase-8 is a molecule in the FAS pathway that initiates apoptosis. One of the rarest autoimmune lymphoproliferative syndromes is caspase-8 deficiency.
Narges Bazgir +10 more
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Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
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The CULt of Caspase-8 Ubiquitination [PDF]
Cell, 2009 Caspase-8 is activated at the plasma membrane by the death-inducing signaling complex (DISC). Jin et al. (2009) show that polyubiquitination of caspase-8, rather than targeting it for proteasomal degradation, is critical for sustaining caspase-8 activity after dissociation from the DISC.
Guy S. Salvesen, Miklós Békés
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GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ
The Iraqi Journal of Agricultural science, 2022 This study examined the potential association between polymorphisms of Caspase 9 −293del (rs4645982) and Caspase8−652 6N ins / del (rs3834129) and the danger of acute and chronic myeloid leukaemia in Iraqi population.
Duaa Abdullah , Reema M. Aloubaidy
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Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
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Caspase‐8 in Apoptosis: The Beginning of “The End”? [PDF]
IUBMB Life, 2000 AbstractCaspase‐8 is a member of the cysteine proteases, which are implicated in apoptosis and cytokine processing. Like all caspases, caspase‐8 is synthesized as an inactive single polypeptide chain zymogen procaspase and is activated by proteolytic cleavage, through either autoactivation after recruitment into a multimeric complex or trans‐cleavage ...
Gerard I. Evan, Marieke Kruidering
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