Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 [PDF]
Cell Reports, 2017 Summary: The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
Nina Van Opdenbosch +14 more
doaj +5 more sources
TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
Cell Death Discovery, 2023 Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated with the development of sarcopenia that is characterized by reduction of muscle fiber size and number ...
Jingying Wu +9 more
doaj +2 more sources
Caspase-8 in inflammatory diseases: a potential therapeutic target. [PDF]
Cell Mol Biol LettCaspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory role in extrinsic apoptosis.
Zhang W +5 more
europepmc +2 more sources
Caspase‐8: regulating life and death [PDF]
Immunological Reviews, 2017 SummaryRoles for cell death in development, homeostasis, and the control of infections and cancer have long been recognized. Although excessive cell damage results in passive necrosis, cells can be triggered to engage molecular programs that result in cell death.
Bart Tummers, Douglas R. Green
openaire +3 more sources
NLK facilitates Caspase‐8 activation to drive macrophage PANoptosis in sepsis [PDF]
Clinical and Translational MedicineMounting evidence indicates that macrophage PANoptosis—an integrated inflammatory cell‐death program comprising pyroptosis, apoptosis, and necroptosis—plays a pivotal role in sepsis pathogenesis. However, its upstream regulation remains poorly understood.
Yun Xia +17 more
doaj +2 more sources
Caspase‐8: not so silently deadly
Clinical & Translational Immunology, 2017 Apoptosis is a caspase‐dependent programmed form of cell death, which is commonly believed to be an immunologically silent process, required for mammalian development and maintenance of cellular homoeostasis. In contrast, lytic forms of cell death, such as RIPK3‐ and MLKL‐driven necroptosis, and caspase‐1/11‐dependent pyroptosis, are postulated to be ...
Feltham, R, Vince, JE, Lawlor, KE
openaire +4 more sources
Cell Reports, 2017 Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD.
Sebastian Horn +9 more
doaj +2 more sources
Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway [PDF]
Journal of NanobiotechnologyRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis, whose pathogenesis remains unclear. Fibroblast-like synoviocytes (FLS) are central to the pathogenesis and progression of RA. This study aims to investigate the novel
Qingcong Zheng +3 more
doaj +2 more sources
Activation of the NLRP1B inflammasome by caspase-8 [PDF]
Communications BiologyCleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome.
Justin J. Meade +5 more
doaj +2 more sources
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Cell Research, 2021 Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (α-KG) induces pyroptosis through caspase-8 ...
Jia-yuan Zhang +12 more
semanticscholar +1 more source