Results 1 to 10 of about 262,302 (283)
Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]
Cell Death and Disease, 2022 Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic communication between endothelial, pericyte, glial, and neuronal cells through signaling ...
Crystal Colón Ortiz +6 more
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CASPASE 9 GENE EXPRESSION AND CASPASE 9 PROTEIN IN CHRONIC MYELOID LEUKEMIA IN IRAQ
The Iraqi Journal of Agricultural science, 2022 The following study was carried out to investigate gene expressions of the CASPASE 9 gene and CASPASE 9 protein with the development of chronic myeloid leukemia (CML) in Iraq.
Abdullah W. K., Maha F. A.
doaj +2 more sources
Quantification of Immunostained Caspase-9 in Retinal Tissue. [PDF]
J Vis Exp, 2022 The family of caspases is known to mediate many cellular pathways beyond cell death, including cell differentiation, axonal pathfinding, and proliferation. Since the identification of the family of cell death proteases, there has been a search for tools to identify and expand the function of specific family members in development, health, and disease ...
Colón Ortiz CK +7 more
europepmc +3 more sources
Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease [PDF]
Frontiers in Pharmacology, 2021 Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration.
Maria I. Avrutsky +3 more
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Caspase-9 swings both ways in the apoptosome [PDF]
Molecular & Cellular Oncology, 2017 For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
doaj +4 more sources
Caspase-9 and APAF-1 form an active holoenzyme [PDF]
Genes & Development, 1999 Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of apoptosis. Activation of caspase-9, which mediates oncogene and drug-induced apoptosis, requires binding to the protein APAF-1.
Joe Rodriguez, Yuri Lazebnik
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Mechanism of XIAP-Mediated Inhibition of Caspase-9 [PDF]
Molecular Cell, 2003 The inhibitor of apoptosis (IAP) proteins potently inhibit the catalytic activity of caspases. While profound insight into the inhibition of the effector caspases has been gained in recent years, the mechanism of how the initiator caspase-9 is regulated by IAPs remains enigmatic.
Eric N. Shiozaki +8 more
openalex +6 more sources
Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling [PDF]
Cells, 2022 Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis.
Min Chen +4 more
doaj +2 more sources
Characterization of a Novel Isoform of Caspase-9 That Inhibits Apoptosis [PDF]
Journal of Biological Chemistry, 2001 We have identified a novel isoform of rat caspase-9 in which the C terminus of full-length caspase-9 is replaced with an alternative peptide sequence. Casp-9-CTD (where CTD is carboxyl-terminal divergent) is expressed in multiple tissues, with the relative highest expression observed in ovary and heart.
James M. Angelastro +5 more
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cDNA cloning and promoter analysis of rat caspase-9 [PDF]
Biochemical Journal, 2001 Caspase-9 is the apex caspase of the mitochondrial pathway of apoptosis, which plays a critical role in apoptotic initiation and progression. However, gene regulation of caspase-9 is largely unknown. This is in part due to the lack of information on the gene promoter.
Junichiro Nishiyama +3 more
openalex +4 more sources