Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease [PDF]
Frontiers in Pharmacology, 2021 Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration.
Maria I. Avrutsky +3 more
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Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients. [PDF]
Clin Psychopharmacol Neurosci, 2023 Objective Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients ...
Dirican E +3 more
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Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury. [PDF]
Curr Neuropharmacol, 2023 Traumatic brain injury (TBI) is one of the significant causes of death and morbidity, and it is hence a focus of translational research. Apoptosis plays an essential part in the pathophysiology of TBI, and its inhibition may help overcome TBI's negative ...
Unnisa A, Greig NH, Kamal MA.
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Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. [PDF]
ACS Chem Biol, 2021 Caspases are a family of enzymes that regulate biological processes such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the ...
Araya LE, Soni IV, Hardy JA, Julien O.
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Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]
Cell Death and Disease, 2022 Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic communication between endothelial, pericyte, glial, and neuronal cells through signaling ...
Crystal Colón Ortiz +6 more
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Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis [PDF]
Journal of Translational MedicineBackground Pulmonary fibrosis (PF) is a progressive interstitial lung disease marked by extracellular matrix accumulation and epithelial damage, with limited therapeutic options.
Juan Wang +9 more
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Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling [PDF]
Cells, 2022 Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis.
Min Chen +4 more
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Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells. [PDF]
PLoS ONE, 2016 Human periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Yaqin Wu +4 more
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Caspase-9 suppresses metastatic behavior of MDA-MB-231 cells in an adaptive organoid model [PDF]
Scientific ReportsCaspase-9, a cysteine-aspartate protease traditionally associated with intrinsic apoptosis, has recently emerged as having non-apoptotic roles, including influencing cell migration—an aspect that has received limited attention in existing studies. In our
Farzaneh Falahi +3 more
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Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]
Cell Death and Disease, 2022 Crystal Colón Ortiz +6 more
doaj +2 more sources