Pharmaceutical Biology, 2019 Context: Epilepsy is a common life-threatening neurological disorder that is often drug-resistant and associated with cognitive impairment. The traditional Chinese patent medicine Songling Xuemaikang capsules (SXC) is clinically used for epilepsy therapy
Haiyan Yang +6 more
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Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia‒reoxygenation [PDF]
, 2000 Zheng Dong +4 more
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Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Bee Venom Inhibits Prostate Cancer Growth in LNCaP Xenografts via Apoptosis
Journal of Pharmacopuncture, 2010 연구목적 : 이 연구는 봉약침의 봉독이 NF-κB 활성억제와 안드로겐 수용체 조절 단백질 및 세포자멸사 조절 단백질의 발현을 통하여 세포자멸사를 유도하고, 전립선 암세포를 이식한 쥐에서의 세포자멸사 유도 효과를 확인함으로써, 봉약침의 봉독이 생체 내에서도 세포자멸사를 유도하여 전립선암에 효과를 나타냄을 확인하고자 하였다.
Yang Chang-yeol, Song Ho-sueb
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Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. [PDF]
iScience, 2023 Yadav PS +3 more
europepmc +1 more source
Advanced Science, EarlyView.The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu +13 more
wiley +1 more source
Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease [PDF]
, 2001 Veena Viswanath +8 more
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Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
Neurobiology of Disease, 2002 Accumulating evidence supports a role for the activation of proteolytic enzymes, caspases, in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so through a mitochondrial pathway employing caspase-9 or through an alternative ...
Troy T. Rohn +5 more
doaj
Inducible caspase 9-mediated suicide gene therapy using AAV6 vectors in a murine model of breast cancer. [PDF]
Mol Ther Methods Clin Dev, 2023 Pathak S +3 more
europepmc +1 more source