Results 141 to 150 of about 282,754 (237)

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Protective effect of quercetin on cadmium-induced renal apoptosis through cyt-c/caspase-9/caspase-3 signaling pathway. [PDF]

Front Pharmacol, 2022
Huang R, Ding L, Ye Y, Wang K, Yu W, Yan B, Liu Z, Wang J.   +7 more
europepmc   +1 more source

Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity

, 2019
Eri Ohta, Masanori Itoh, Masashi Ueda, Yoko Hida, Miao-xing Wang, Miki Hayakawa-Ogura, Shimo Li, Emika Nishida, Kazunori Ohta, Tana Tana, Saiful Islam, K. Nakagawa, Tomomi Sunayama, Huayue Chen, So Hirata, Masashi Endo, Yoya Ohno, Toshiyuki Nakagawa   +17 more
openalex   +2 more sources

Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity [PDF]

, 2014
Miki Ando, Valentina Hoyos, Shigeki Yagyu, Tao Wang, Carlos A. Ramos, Gianpietro Dotti, Malcolm K. Brenner, Lisa Bouchier‐Hayes   +7 more
openalex   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Alterations of caspase 9 mRNA gene expression in survivors and nonsurvivors of severe sepsis [PDF]

, 2010
Mary White, Derek G. Doherty, Dermot Kelleher, Ross McManus, Thomas Ryan   +4 more
openalex   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction. [PDF]

Front Immunol
Sternkopf LE, Prodjinotho UF, Gres V, Repgen N, Steiger K, Schluckebier J, Sikasunge CS, Stelzle D, Makasi C, Winkler AS, Ngowi BJ, Villalobos N, Ebner F, Häcker G, Henneke P, Prazeres da Costa C.   +15 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling. [PDF]

Nat Commun
Matsui K, Watanabe M, Yamamoto S, Kawagoe S, Ikeda T, Ohashi H, Kuroda T, Koda N, Morimoto K, Kinoshita Y, Inage Y, Saito Y, Fukunaga S, Fujimoto T, Tajiri S, Matsumoto K, Kobayashi E, Yokoo T, Yamanaka S.   +18 more
europepmc   +1 more source