Results 21 to 30 of about 262,302 (283)
Apoptosis and autophagy: Regulation of caspase‐9 by phosphorylation [PDF]
The FEBS Journal, 2009 Cell death by the process of apoptosis plays important roles in development, tissue homeostasis, diseases and drug responses. The cysteine aspartyl protease caspase‐9 plays a central role in the mitochondrial or intrinsic apoptotic pathway that is engaged in response to many apoptotic stimuli.
Allan, Lindsey A., Clarke, Paul R.
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Caspase-9 cleavage, do you need it? [PDF]
Biochemical Journal, 2007 Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell-death programme. Although caspase-9 does not need to be cleaved to be active, apoptotic cell death is always accompanied
Twiddy, Davina, Cain, Kelvin
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Regulation of the Apaf-1–caspase-9 apoptosome [PDF]
Journal of Cell Science, 2010 Apoptosis is probably not the only form of cell death, but it is currently the only form for which the proteins that constitute the death pathway have been characterized at the structural, biochemical and genetic levels in great detail.
Guy S. Salvesen, Shawn B. Bratton
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The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125 [PDF]
Journal of Biological Chemistry, 2008 Caspase-9 plays a critical role in the initiation of apoptosis by the mitochondrial pathway. Activation of caspase-9 is inhibited by phosphorylation at Thr(125) by ERK1/2 MAPKs in response to growth factors. Here, we show that phosphorylation of this site is specific for these classical MAPKs and is not strongly induced when JNK and p38alpha/beta MAPKs
Martin, Morag C. +3 more
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Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]
Protein Science, 2012 AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Jeanne A. Hardy, Kristen L. Huber
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Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
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Caspase 9 Promoter Polymorphisms (-1263G>A, -905T>G, -712C>T) in Coronary Artery Disease [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Apoptosis has been involved in a number of pathological conditions including Coronary Artery Disease (CAD). Caspases are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways.
KISHORE KUMAR GUNDAPANENI +6 more
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Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]
Biochemical Journal, 2002 Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Jennifer B Burch +5 more
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Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
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Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [PDF]
PLoS Biology, 2005 Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function.
Yang Chao +5 more
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