Results 31 to 40 of about 262,302 (283)
Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]
Proceedings of the National Academy of Sciences, 1998 Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery.
Howard O. Fearnhead +6 more
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The Expression and Prognosis of Caspase-9 in Hepatocellular Carcinoma [PDF]
International Journal of Sciences, 2017 Objective: We aim to investigate the expression of Caspase-9 and its prognostic significance in hepatocellular carcinoma (HCC). Methods: The expression of Caspase-9 in 108 specimens of HBV-related HCC, 30 cases of cirrhosis tissue and 20 cases of normal liver tissue was examined by immunohistochemical staining.
Lingling Sun +4 more
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Caspase-9: structure, mechanisms and clinical application
Oncotarget, 2017 As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens ...
Xiongxiong Liu +7 more
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Caspase‐9 acts as a regulator of necroptotic cell death [PDF]
The FEBS Journal, 2021 Necroptosis is a regulated necrotic‐like cell death modality which has come into the focus of attention since it is known to contribute to the pathogenesis of many inflammatory and degenerative diseases as well as to tumor regulation. Based on current data, necroptosis serves as a backup mechanism when death receptor‐induced apoptosis is inhibited or ...
Tamás Molnár +16 more
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A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
Journal of Cell Science, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role that has been described is the requirement of caspase-3 for the differentiation of skeletal myoblasts into myotubes but, as yet ...
Murray, Thomas VA +7 more
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Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation
مجله دانشگاه علوم پزشکی بیرجند, 2023 Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin +3 more
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Destabilizing Effect of Caspase-9 Association with Apoptosome [PDF]
Biophysical Journal, 2016 Intrinsic pathway of Apoptosis is initiated by the release of cytochrome C from mitochondria leading to the formation of a mega Dalton complex called apoptosome. Apoptosome, which consists of seven molecules of Apaf-1, serves as a platform for the oligomerization and activation of procaspase-9.
Jamshid Davoodi +5 more
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Veterinární Medicína, 2013 The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA).
A. Aydogan, M. Haligur, O. Ozmen
doaj +1 more source
Expression of caspase 9 and p53 in uterine leiomyosarcomas
Polish Gynaecology, 2014 Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis.The aim of the study was to assess the ...
Wiesława Bednarek +5 more
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Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo [PDF]
Cell, 1998 Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis. Casp9-/- embryonic stem cells and embryonic fibroblasts are resistant to several apoptotic stimuli, including UV and gamma irradiation.
Minna Woo +27 more
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