Results 31 to 40 of about 274,264 (283)
Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]
Biochemical Journal, 2002 Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Jennifer B Burch +5 more
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Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]
Proceedings of the National Academy of Sciences, 1998 Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery.
Howard O. Fearnhead +6 more
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Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
doaj +1 more source
The Expression and Prognosis of Caspase-9 in Hepatocellular Carcinoma [PDF]
International Journal of Sciences, 2017 Objective: We aim to investigate the expression of Caspase-9 and its prognostic significance in hepatocellular carcinoma (HCC). Methods: The expression of Caspase-9 in 108 specimens of HBV-related HCC, 30 cases of cirrhosis tissue and 20 cases of normal liver tissue was examined by immunohistochemical staining.
Lingling Sun +4 more
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Caspase-9: structure, mechanisms and clinical application
Oncotarget, 2017 As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens ...
Xiongxiong Liu +7 more
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Caspase‐9 acts as a regulator of necroptotic cell death [PDF]
The FEBS Journal, 2021 Necroptosis is a regulated necrotic‐like cell death modality which has come into the focus of attention since it is known to contribute to the pathogenesis of many inflammatory and degenerative diseases as well as to tumor regulation. Based on current data, necroptosis serves as a backup mechanism when death receptor‐induced apoptosis is inhibited or ...
Tamás Molnár +16 more
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Destabilizing Effect of Caspase-9 Association with Apoptosome [PDF]
Biophysical Journal, 2016 Intrinsic pathway of Apoptosis is initiated by the release of cytochrome C from mitochondria leading to the formation of a mega Dalton complex called apoptosome. Apoptosome, which consists of seven molecules of Apaf-1, serves as a platform for the oligomerization and activation of procaspase-9.
Jamshid Davoodi +5 more
openaire +2 more sources
A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
Journal of Cell Science, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role that has been described is the requirement of caspase-3 for the differentiation of skeletal myoblasts into myotubes but, as yet ...
Murray, Thomas VA +7 more
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Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo [PDF]
Cell, 1998 Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis. Casp9-/- embryonic stem cells and embryonic fibroblasts are resistant to several apoptotic stimuli, including UV and gamma irradiation.
Minna Woo +27 more
openaire +3 more sources
Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation
مجله دانشگاه علوم پزشکی بیرجند, 2023 Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin +3 more
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