Results 31 to 40 of about 301,365 (321)

Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]

Protein Science, 2012
AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Jeanne A. Hardy, Kristen L. Huber
openaire   +3 more sources

TRAIL Enhances Apoptosis of Human Hepatocellular Carcinoma Cells Sensitized by Hepatitis C Virus Infection: Therapeutic Implications [PDF]

, 2014
Hepatitis C virus (HCV) infection causes chronic liver diseases leading to hepatocellular carcinoma (HCC) and liver failure. We have previously shown that HCV sensitizes hepatocytes to mitochondrial apoptosis via the TRAIL death receptors DR4 and DR5 ...
Cho, Eun Kyung, Chung, Raymond T., Jang, Jae Young, Jeong, Soung Won, Kim, Boo Sung, Kim, Hong Soo, Kim, Sang Gyune, Kim, Seong-Jun, Kim, Young Seok, Lee, Sae Hwan, Lee, Woong Cheul, Lin, Wenyu, Park, Eui Ju   +12 more
core   +8 more sources

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]

Biochemical Journal, 2002
Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Jennifer B Burch, Ciara A Ryan, J. Marie Hardwick, Guy S. Salvesen, Henning R. Stennicke, Victor E. Nava   +5 more
openaire   +3 more sources

Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis [PDF]

, 2008
Caspase-9 is the protease that mediates the intrinsic pathway of apoptosis, a type of cell death. Activation of caspase-9 is a multi-step process that requires dATP or ATP and involves at least two proteins, cytochrome c and Apaf-1.
Antoniotti, M., Lin, S. c., Mishra, B., Ryu, S., Ugel, N.   +4 more
core   +2 more sources

Beneficial role of allicin from garlic in cervical cancer [PDF]

, 2008
Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells.
Irfan Ahmad Ansari, Najmul Islam
core   +2 more sources

Caspase 9 Promoter Polymorphisms (-1263G>A, -905T>G, -712C>T) in Coronary Artery Disease [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Apoptosis has been involved in a number of pathological conditions including Coronary Artery Disease (CAD). Caspases are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways.
KISHORE KUMAR GUNDAPANENI, NIVAS SHYAMALA, KAUSHIK PURANAM, RAJESH KUMAR GALIMUDI, KEERTHI KUPSAL, KRISHNA REDDY NALLAMALA, SUREKHA RANI HANUMANTH   +6 more
doaj   +1 more source

Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

Cells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata, Emi Maeno, Yasunobu Okada   +2 more
doaj   +1 more source

Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]

, 2013
Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda, Bodur, Çağrı, Harrison, Paul, Isimjan, Tayirjan T., Karslı, Gizem, Kütük, Özgür   +5 more
core   +1 more source

Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]

Proceedings of the National Academy of Sciences, 1998
Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery.
Howard O. Fearnhead, Eve-Ellen Govek, Greg Hannon, Wenjun Guo, Ryuji Kobayashi, Joe Rodriguez, Yuri Lazebnik   +6 more
openaire   +3 more sources