Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]
, 2009 The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele +8 more
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Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
Nature Communications, 2020 Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the ...
Maria I. Avrutsky +13 more
semanticscholar +1 more source
Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]
, 2013 Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal +52 more
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A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O +7 more
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Proteolytic Processing of the Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9 [PDF]
Journal of Biological Chemistry, 2013 Maturation of the single-chain caspase-9 zymogen through autoproteolytic processing is mediated by the Apaf-1 apoptosome at the onset of apoptosis. Processed caspase-9 and the apoptosome form a holoenzyme with robust proteolytic activity that is 2-3 orders of magnitude higher than that of free processed caspase-9.
Qi, Hu +4 more
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MDA-MB-231 cell apoptosis in vitro induced by dihydromyricetin
浙江大学学报. 农业与生命科学版, 2012 To investigate the effect of dihydromyricetin (DMY) induction on MDA-MB-231 cell apoptosis and its mechanism, the changes of cell morphological characteristics were observed under inverted microscope.
ZHOU Fang-zhen +3 more
doaj +1 more source
CASP-9 (caspase 9, apoptosis-related cysteine peptidase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CASP-9 (caspase 9, apoptosis-related cysteine peptidase), with data on DNA, on the protein encoded, and where the gene is implicated.
DI BARTOLOMEO, Sabrina, Cecconi F.
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Regulation of the Apaf-1–caspase-9 apoptosome [PDF]
Journal of Cell Science, 2010 Apoptosis is probably not the only form of cell death, but it is currently the only form for which the proteins that constitute the death pathway have been characterized at the structural, biochemical and genetic levels in great detail.
Shawn B, Bratton, Guy S, Salvesen
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Al-Azhar Assiut Medical Journal, 2017 Background Vitiligo is the most common depigmentation disorder of the skin. It is considered a multifactorial disorder. However, its exact etiology is unknown.
Eman R.M Hofny +4 more
doaj +1 more source
Beneficial role of allicin from garlic in cervical cancer [PDF]
, 2008 Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells.
Irfan Ahmad Ansari, Najmul Islam
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