Results 41 to 50 of about 5,120,269 (330)
Mechanism of XIAP-Mediated Inhibition of Caspase-9 [PDF]
Molecular Cell, 2003 The inhibitor of apoptosis (IAP) proteins potently inhibit the catalytic activity of caspases. While profound insight into the inhibition of the effector caspases has been gained in recent years, the mechanism of how the initiator caspase-9 is regulated by IAPs remains enigmatic.
Shiozaki, Eric N +8 more
openaire +3 more sources
Virology Journal, 2012 Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme +11 more
doaj +1 more source
Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]
Protein Science, 2012 AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Kristen L, Huber, Jeanne A, Hardy
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BMC Complementary Medicine and Therapies, 2020 Background The Chinese herbal compound Heshouwuyin has been shown to downregulate the apoptotic rate of testicular tissue cells in Wistar naturally aging rats, and this effect might be related to the mitochondrial pathway [15].
Hongjie Wang +8 more
semanticscholar +1 more source
Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [PDF]
PLoS Biology, 2005 Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function.
Yang Chao +5 more
doaj +1 more source
Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis [PDF]
, 2008 Caspase-9 is the protease that mediates the intrinsic pathway of apoptosis, a type of cell death. Activation of caspase-9 is a multi-step process that requires dATP or ATP and involves at least two proteins, cytochrome c and Apaf-1.
Ryu, S. +4 more
core +1 more source
Inhibitor specificity of recombinant and endogenous caspase-9 [PDF]
Biochemical Journal, 2002 Apoptosis triggered through the intrinsic pathway by radiation and anti-neoplastic drugs is initiated by the activation of caspase-9. To elucidate control mechanisms in this pathway we used a range of synthetic and natural reagents. The inhibitory potency of acetyl-Asp-Glu-Val-Asp-aldehyde ('Ac-DEVD-CHO'), benzyloxycarbonyl-Val-Ala-Asp ...
Ciara A, Ryan +5 more
openaire +2 more sources
Caspase-9 Can Be Activated without Proteolytic Processing [PDF]
Journal of Biological Chemistry, 1999 The recombinant form of the proapoptotic caspase-9 purified following expression in Escherichia coli is processed at Asp315, but largely inactive; however, when added to cytosolic extracts of human 293 cells it is activated 2000-fold in the presence of cytochrome c and dATP.
H R, Stennicke +5 more
openaire +2 more sources
Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda +5 more
core +1 more source
Cells, 2012 Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata +2 more
doaj +1 more source