Results 41 to 50 of about 301,365 (321)
The Expression and Prognosis of Caspase-9 in Hepatocellular Carcinoma [PDF]
International Journal of Sciences, 2017 Objective: We aim to investigate the expression of Caspase-9 and its prognostic significance in hepatocellular carcinoma (HCC). Methods: The expression of Caspase-9 in 108 specimens of HBV-related HCC, 30 cases of cirrhosis tissue and 20 cases of normal liver tissue was examined by immunohistochemical staining.
Lingling Sun +4 more
openaire +2 more sources
Biomolecules, 2020 Notably, 6-Shogaol, a bioactive natural substance, has anticancer effects on many types of tumors. Up to date, the anticancer effect and mode of action of 6-Shogaol on liposarcoma are not known.
Anil Kumar Yadav, Byeong-Churl Jang
doaj +1 more source
Caspase-9: structure, mechanisms and clinical application
Oncotarget, 2017 As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens ...
Xiongxiong Liu +7 more
openaire +4 more sources
Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo [PDF]
, 2010 BACKGROUND: To evaluate whether PI3K/Akt pathway could effect on apoptosis and its mechanism in nasopharyngeal carcinoma cells. METHODS: The activation of the PI3K/Akt and its effect on CNE-2Z cells in vivo and in vitro was investigated by MTT assay ...
Desheng Fan +4 more
core +2 more sources
Caspase‐9 acts as a regulator of necroptotic cell death [PDF]
The FEBS Journal, 2021 Necroptosis is a regulated necrotic‐like cell death modality which has come into the focus of attention since it is known to contribute to the pathogenesis of many inflammatory and degenerative diseases as well as to tumor regulation. Based on current data, necroptosis serves as a backup mechanism when death receptor‐induced apoptosis is inhibited or ...
Tamás Molnár +16 more
openaire +4 more sources
Suppression of the intrinsic apoptosis pathway by sinaptic activity [PDF]
, 2014 Synaptic activity promotes resistance to diverse apoptotic insults, the mechanism behind which is incompletely understood. We show here that a coordinated downregulation of core components of the intrinsic apoptosis pathway by neuronal activity forms a ...
Bell, Karen F. S. +11 more
core +2 more sources
Destabilizing Effect of Caspase-9 Association with Apoptosome [PDF]
Biophysical Journal, 2016 Intrinsic pathway of Apoptosis is initiated by the release of cytochrome C from mitochondria leading to the formation of a mega Dalton complex called apoptosome. Apoptosome, which consists of seven molecules of Apaf-1, serves as a platform for the oligomerization and activation of procaspase-9.
Jamshid Davoodi +5 more
openaire +2 more sources
Structure and Activation Mechanism of the Drosophila Initiator Caspase Dronc [PDF]
, 2006 Activation of an initiator caspase is essential to the execution of apoptosis. The molecular mechanisms by which initiator caspases are activated remain poorly understood.
Demeler, Borries +5 more
core +1 more source
Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation
مجله دانشگاه علوم پزشکی بیرجند, 2023 Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin +3 more
doaj
Veterinární Medicína, 2013 The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA).
A. Aydogan, M. Haligur, O. Ozmen
doaj +1 more source