Results 11 to 20 of about 580,743 (343)
Identification of a new caspase homologue: caspase-14 [PDF]
Cell Death & Differentiation, 1998 Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. Here, we report the identification of a new murine caspase homologue, viz. caspase-14. It is most related to human/murine caspase-2 and human caspase-9, possesses all the typical amino acid residues of the caspases involved in catalysis, including the
Marc Van de Craen +8 more
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Caspase-2: the orphan caspase [PDF]
Cell Death & Differentiation, 2011 Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
Lisa Bouchier-Hayes, Douglas R. Green
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Are metacaspases caspases? [PDF]
The Journal of Cell Biology, 2007 The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal.
Peter Vandenabeele +5 more
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Cell Death & Differentiation, 2011 Evasion of apoptosis is considered to be one of the hallmarks of human cancers. This cell death modality is executed by caspases and several upstream regulatory factors, which direct their proteolytic activity, have been defined as either tumor suppressors or oncogenes.
Boris Zhivotovsky, Magnus Olsson
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Oncogene, 2003 Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and ...
Degterev, Alexei +2 more
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Journal of Neuroscience Research, 2002 AbstractThe basic mechanisms that underlie neurodegenerative diseases are unknown. Loss of function of specific regions of the brain is due to incapacitation of cells that constitute those regions. Cells can simply stop functioning normally (neurons may cease to transmit signals), or they may die.
Guy S. Salvesen, Carol M. Troy
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Beneficial role of allicin from garlic in cervical cancer [PDF]
, 2008 Introduction: Cervical cancer remains a global health concern for females. Thus, in order to control cervical cancer, attempts are being made by researchers globally to somehow induce programmed cell death in the said cancerous cells.
Irfan Ahmad Ansari, Najmul Islam
core +2 more sources
Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]
, 2017 The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke +14 more
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Caspases and their substrates [PDF]
Cell Death & Differentiation, 2017 Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis. More recently, caspases have been shown to be involved in other cellular remodeling events as well including ...
Olivier Julien, James A Wells
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HEPATITIS C VIRUS AND HOST CELL NUCLEAR TRANSPORT MACHINERY: A CLANDESTINE AFFAIR
Frontiers in Microbiology, 2015 There is growing evidence that factors encoded by cytoplasmic replicating viruses functionally interact with components of the nucleocytoplasmic transport apparatus.
Barbara eBonamassa +5 more
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