Results 11 to 20 of about 526,882 (310)

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

Sci, 2022
Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and ...
Vishakha Singh, Amit Khurana, Umashanker Navik, Prince Allawadhi, Kala Kumar Bharani, Ralf Weiskirchen   +5 more
doaj   +1 more source

A Potential Mechanism for the Anti-Apoptotic Property of Koumine Involving Mitochondrial Pathway in LPS-Mediated RAW 264.7 Macrophages

Molecules, 2016
Koumine is a kind of alkaloid extracted from Gelsemium elegans (G. elegans). Benth, which has shown promise as an anti-tumor, anxiolytic, and analgesic agent. In our present study, the effect of koumine on lipopolysaccharide (LPS)-mediated RAW 264.7 cell
Zhi-Hang Yuan, Zeng-Enni Liang, Jing Wu, Jin-E Yi, Xiao-Jun Chen, Zhi-Liang Sun   +5 more
doaj   +1 more source

Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres

Viruses, 2020
Influenza A virus (IAV) exploits host factors to multiply and cause disease. An in-depth knowledge of this interaction of IAV with the host will aid the development of anti-IAV intervention strategies.
Da-Yuan Chen, Matloob Husain
doaj   +1 more source

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1

Molecular & Cellular Oncology, 2021
Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids.
Pierre Raia, Jun Yu, Andreas Boland
doaj   +1 more source

Interferon-Induced Protein 6-16 (IFI6-16) from Litopenaeus vannamei Regulate Antiviral Immunity via Apoptosis-Related Genes

Viruses, 2022
A growing number of evidence shows that some invertebrates possess an antiviral immunity parallel to the interferon (IFN) system of higher vertebrates.
Kai Lǚ, Haoyang Li, Sheng Wang, Anxing Li, Shaoping Weng, Jianguo He, Chaozheng Li   +6 more
doaj   +1 more source

Extracts of Artocarpus communis Induce Mitochondria-Associated Apoptosis via Pro-oxidative Activity in Human Glioblastoma Cells

Frontiers in Pharmacology, 2018
Glioblastoma multiforme (GBM) is an extremely aggressive and devastating malignant tumor in the central nervous system. Its incidence is increasing and the prognosis is poor. Artocarpin is a natural prenylated flavonoid with various anti-inflammatory and
Chiang-Wen Lee, Chiang-Wen Lee, Chiang-Wen Lee, Lee-Fen Hsu, Ming-Hsueh Lee, I.-Ta Lee, Ju-Fang Liu, Yao-Chang Chiang, Yao-Chang Chiang, Ming-Horng Tsai, Ming-Horng Tsai   +10 more
doaj   +1 more source

Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host ...
Ana Luisa Gomes Mendes, Heloísa Di Matteo Joaquim, Mara Inês Stefanini Zamae, Ramon Meira Assis, Jéssica Renata de Moura Peixoto, Margarida Maria Gomes de Araújo, Antônio Carlos Martins Guedes, Edward José Oliveira, Vanessa Peruhype Magalhães, Marcelo Antônio Pascoal-Xavier   +9 more
doaj   +1 more source

The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

Cell Death Discovery, 2020
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation.
Mingxia Jiang, L. Qi, Lisha Li, Yanjing Li   +3 more
semanticscholar   +1 more source

Low pH Attenuates Apoptosis by Suppressing the Volume-Sensitive Outwardly Rectifying (VSOR) Chloride Current in Chondrocytes

Frontiers in Cell and Developmental Biology, 2022
In a variety of physiological and pathophysiological conditions, cells are exposed to acidic environments. Severe synovial fluid acidification also occurs in a progressive state of osteoarthritis (OA) affecting articular chondrocytes.
Michael Kittl, Michael Kittl, Martina Winklmayr, Martina Winklmayr, Julia Preishuber-Pflügl, Julia Preishuber-Pflügl, Victoria Strobl, Victoria Strobl, Martin Gaisberger, Martin Gaisberger, Martin Gaisberger, Markus Ritter, Markus Ritter, Markus Ritter, Markus Ritter, Martin Jakab, Martin Jakab   +16 more
doaj   +1 more source

Nanoparticle-based and bioengineered probes and sensors to detect physiological and pathological biomarkers in neural cells

Frontiers in Neuroscience, 2015
Nanotechnology, a rapidly evolving field, provides simple and practical tools to investigate the nervous system in health and disease. Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of ...
Dusica eMaysinger, Jeff eJi, Eliza eHutter, Ellis eCooper   +3 more
doaj   +1 more source