Results 21 to 30 of about 580,743 (343)
Frontiers in Veterinary Science, 2021 Caspases, a family of cysteine protease enzymes, are a critical component of apoptotic cell death, but they are also involved in cellular differentiation.
Wonchul Jung +8 more
doaj +1 more source
A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O +7 more
core +1 more source
Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons
Marine Drugs, 2015 The frequent occurrence of Moorea producens (formerly Lyngbya majuscula) blooms has been associated with adverse effects on human health. Hoiamide A is a structurally unique cyclic depsipeptide isolated from an assemblage of the marine cyanobacteria M ...
Zhengyu Cao +5 more
doaj +1 more source
The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria [PDF]
, 2014 Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
A Filippini +53 more
core +2 more sources
Cell Death & Differentiation, 2000 Caspases, a group of cysteine proteases, constitute the effector arm of the cell death machinery. There are seven caspases known in Drosophila, three of which contain long amino-terminal prodomains. Although, compared to mammalian caspases, much less is known about the biology of Drosophila caspases, many studies have shown that caspases are essential ...
Sharad Kumar, J Doumanis
openaire +3 more sources
Dissecting apoptosis the omics way
eLife, 2013 A combined analysis of transcription, translation and protein degradation reveals the global effects of an anticancer drug on tumour cells.
Petra Van Damme
doaj +1 more source
A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation [PDF]
, 2015 Lymphocyte apoptosis is mainly induced by either death receptor-dependent activation of caspase-8 or mitochondria-dependent activation of caspase-9. Mutations in caspase-8 lead to autoimmunity/lymphoproliferation and immunodeficiency. This work describes
Boggio, E +15 more
core +2 more sources
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]
, 2016 Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E +7 more
core +1 more source
Non-apoptotic roles of apoptotic proteases: new tricks for an old dog [PDF]
Open Biology, 2020 This Open Question article highlights current advances in the study of non-apoptotic roles of apoptotic proteins. Apoptosis is a highly regulated and energy-requiring process in which cells actively kill themselves.
Tin Tin Su
doaj +1 more source
Global cellular response to chemotherapy-induced apoptosis
eLife, 2013 How cancer cells globally struggle with a chemotherapeutic insult before succumbing to apoptosis is largely unknown. Here we use an integrated systems-level examination of transcription, translation, and proteolysis to understand these events central to ...
Arun P Wiita +7 more
doaj +1 more source