Results 21 to 30 of about 514,126 (359)
Viruses, 2022 A growing number of evidence shows that some invertebrates possess an antiviral immunity parallel to the interferon (IFN) system of higher vertebrates.
Kai Lǚ +6 more
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Caspases and their substrates [PDF]
Cell Death & Differentiation, 2017 Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis. More recently, caspases have been shown to be involved in other cellular remodeling events as well including ...
Olivier Julien, James A Wells
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Frontiers in Pharmacology, 2018 Glioblastoma multiforme (GBM) is an extremely aggressive and devastating malignant tumor in the central nervous system. Its incidence is increasing and the prognosis is poor. Artocarpin is a natural prenylated flavonoid with various anti-inflammatory and
Chiang-Wen Lee +10 more
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Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae [PDF]
Memorias do Instituto Oswaldo Cruz, 2020 BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host ...
Ana Luisa Gomes Mendes +9 more
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Cell Death & Differentiation, 2000 Caspases, a group of cysteine proteases, constitute the effector arm of the cell death machinery. There are seven caspases known in Drosophila, three of which contain long amino-terminal prodomains. Although, compared to mammalian caspases, much less is known about the biology of Drosophila caspases, many studies have shown that caspases are essential ...
Sharad Kumar, J Doumanis
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Frontiers in Cell and Developmental Biology, 2022 In a variety of physiological and pathophysiological conditions, cells are exposed to acidic environments. Severe synovial fluid acidification also occurs in a progressive state of osteoarthritis (OA) affecting articular chondrocytes.
Michael Kittl +16 more
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Frontiers in Neuroscience, 2015 Nanotechnology, a rapidly evolving field, provides simple and practical tools to investigate the nervous system in health and disease. Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of ...
Dusica eMaysinger +3 more
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Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways [PDF]
International Journal of Ophthalmology, 2019 AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin (GFX) to stromal fibroblasts (SFs) in vitro. METHODS: SFs were treated with GFX at different concentrations (0.009375%-0.3%), and their viability was detected by MTT method. The cell
Bin Xu, Yun-Long Sui, Ting-Jun Fan
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Expression of Caspases and Their Substrates in the Rat Model of Focal Cerebral Ischemia
Neurobiology of Disease, 2000 Experimental evidence suggests that the massive release of glutamate during experimental brain ischemia both directly and indirectly regulates downstream mechanisms of cell suicide.
Jerzy Krupinski +3 more
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Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities
Plants, 2020 Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A high performance liquid chromatography diode array revealed several polyphenols in the leaf extracts
Hosam O. Elansary +5 more
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