Results 21 to 30 of about 526,882 (310)
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways [PDF]
International Journal of Ophthalmology, 2019 AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin (GFX) to stromal fibroblasts (SFs) in vitro. METHODS: SFs were treated with GFX at different concentrations (0.009375%-0.3%), and their viability was detected by MTT method. The cell
Bin Xu, Yun-Long Sui, Ting-Jun Fan
doaj +1 more source
Expression of Caspases and Their Substrates in the Rat Model of Focal Cerebral Ischemia
Neurobiology of Disease, 2000 Experimental evidence suggests that the massive release of glutamate during experimental brain ischemia both directly and indirectly regulates downstream mechanisms of cell suicide.
Jerzy Krupinski +3 more
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Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities
Plants, 2020 Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A high performance liquid chromatography diode array revealed several polyphenols in the leaf extracts
Hosam O. Elansary +5 more
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Caspase‐8: A key protein of cross‐talk signal way in “PANoptosis” in cancer
International Journal of Cancer, 2021 Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells.
Mingxia Jiang +5 more
semanticscholar +1 more source
Toxins, 2011 Ricin is a highly toxic type II ribosome-inactivating protein that has potential as a biochemical weapon and as the toxic component of immunotoxins. The unfolded protein response (UPR) is a survival response that helps cells to recover from endoplasmic ...
Wendie S. Cohick +3 more
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Nature, 2009 The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung +7 more
semanticscholar +1 more source
Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
Toxins, 2019 Garcinol, an anti-inflammatory and anti-carcinogenic polyisoprenylated benzophenone isolated from Garcinia plants, stimulates tumor cell apoptosis and suicidal erythrocyte death, but supports the survival of hepatocytes and neurons.
Hang Cao +8 more
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An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Science, 2020 Liver disease defect identified The energy sensor adenosine monophosphate–activated protein kinase (AMPK) is implicated in liver damage in nonalcoholic steatohepatitis (NASH), a leading cause of liver-associated death in humans. Zhao et al.
Peng Zhao +10 more
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Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma
Frontiers in Cell and Developmental BiologyGlaucoma is a complex disease of the optic nerve leading to vision loss and blindness, with high worldwide incidence and disproportionate prevalence in older populations.
Nisha Rajakrishna +9 more
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Nature Communications, 2019 Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Corey Rogers +5 more
semanticscholar +1 more source