Results 31 to 40 of about 333,383 (311)
Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]
Journal of Molecular Biology, 2018 Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya +4 more
openaire +4 more sources
Molecules, 2014 Cervical cancer is the second most common female carcinoma. Current therapies are often unsatisfactory, especially for advanced stage patients. The aim of this study was to explore the effects of tatariside G (TG) on apoptosis in human cervical cancer ...
Yuan Li +7 more
doaj +1 more source
Kinetic Monte Carlo study of the type1/type 2 choice in apoptosis elucidates selective killing of cancer cells under death ligand induction [PDF]
OJApo 4 (2015) 22-39, 2015 Death ligand mediated apoptotic activation is a mode of programmed cell death that is widely used in cellular and physiological situations. Interest in studying death ligand induced apoptosis has increased due to the promising role of recombinant soluble forms of death ligands (mainly recombinant TRAIL) in anti-cancer therapy.
arxiv +1 more source
Ceramide-Induced Cell Death Depends on Calcium and Caspase-Like Activity in Rice
Frontiers in Plant Science, 2020 Ceramide sphingolipids are major components of membranes. C2 and C6 ceramides induce programmed cell death (PCD) in animals and plants, and we previously showed that C2 and C6 ceramides induce PCD in rice (Oryza sativa) protoplasts.
Quan-Fang Zhang +7 more
doaj +1 more source
Pyroptosis: A Developing Foreland of Ovarian Cancer Treatment
Frontiers in Oncology, 2022 Ovarian cancer (OVCA) has the second highest mortality among all gynecological cancers worldwide due to its complexity and difficulty in early-stage diagnosis and a lack of targeted therapy.
Tianyi Liu +12 more
doaj +1 more source
Death ligand concentration and the membrane proximal signaling module regulate the type 1/ type 2 choice in apoptotic death signaling [PDF]
, 2015 Apoptotic death pathways are frequently activated by death ligand induction and subsequent activation of the membrane proximal signaling module. Death receptors cluster upon binding to death ligands, leading to formation of a membrane proximal death-inducing-signaling-complex (DISC). In this membrane proximal signalosome, initiator caspases (caspase 8)
arxiv +1 more source
DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]
Journal of Biological Chemistry, 1999 Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L. +4 more
openaire +4 more sources
Striking a balance: Modulation of host cell death pathways by Legionella pneumophila
Frontiers in Cellular and Infection Microbiology, 2011 Programmed cell death is considered the ultimate solution for the host to eliminate infected cells, leading to the abolishment of the niche for microbial replication and the ablation of infection.
Zhao-Qing eLuo
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2018 Objective: To evaluate the anticancer activity of crude acetone and water leaf extracts of Tulbaghia violacea on a human oral cancer cell line (KB). Methods: The antioxidant activity of the leaf extracts was evaluated by using the DPPH assay while the ...
Samkeliso Takaidza +5 more
doaj +1 more source
Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different [PDF]
Open Biology, 2018 The ability to regenerate is a fundamental requirement for tissue homeostasis. Regeneration draws on three sources of cells. First and best-studied are dedicated stem/progenitor cells.
Tin Tin Su
doaj +1 more source