Results 31 to 40 of about 526,882 (310)

Evaluation of Cytotoxic and Apoptotic Effects of Simvastatin in Bone Cancer Cell line(MG-63)

Armaghane Danesh Bimonthly Journal, 2020
Background & aim: Cancer is a mismatch between cell growth and death that results in excessive accumulation of cells. Bone cancer is a very serious type of cancer and occurs when osteoporotic cells have problems. The aim of this study was to evaluate the
MA Soltani, T Naji, R Ahmadi
doaj  

Alpinia galanga induces caspase-dependent apoptotic cell death in human lung and cervical cancer cells [PDF]

Journal of HerbMed Pharmacology
Introduction: Alpinia galanga (L.) Willd is a rhizomatous, recurrent herb used to treat numerous diseases, including cancer. This study examines the efficiency of the different parts of A.
Alex Zohmachhuana, Nachimuthu Senthil Kumar, Malsawmdawngliana Malsawmdawngliana, Vabeiryureilai Mathipi, Lalrinzuali Lalrinzuali, Thangaraj Parimelazhagan, F. Lalnunmawia   +6 more
doaj   +1 more source

Delving into the Causes and Effects of Entomopathogenic Endophytic Metarhizium brunneum Foliar Application-Related Mortality in Spodoptera littoralis Larvae

Insects, 2020
The aim of the current study was to delve into the causes of mortality of Spodoptera littoralis larvae feeding on Metarhizium-colonized plants in the absence of fungal outgrowth on the cadavers as previous studies reported and to elucidate the possible ...
Inmaculada Garrido-Jurado, David Montes-Moreno, Pilar Sanz-Barrionuevo, Enrique Quesada-Moraga   +3 more
doaj   +1 more source

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Here we demonstrate that Yersinia YopJ-induced murine macrophage death involves caspase-8–induced cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME).
Joseph Sarhan, Beiyun C. Liu, Hayley I. Muendlein, Peng Li, R. Nilson, Amy Y. Tang, A. Rongvaux, S. Bunnell, F. Shao, D. Green, A. Poltorak   +10 more
semanticscholar   +1 more source

Caspase-9.

International Journal of Biochemistry and Cell Biology, 2020
Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 ...
K. Kuida
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans

eLife, 2022
In the aging brain, many of the alterations underlying cognitive and behavioral decline remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a simple, well-studied nervous system to further our understanding of the ...
Gregory S Wirak, Jeremy Florman, Mark J Alkema, Christopher W Connor, Christopher V Gabel   +4 more
doaj   +1 more source

Caspase-1 initiates apoptosis in the absence of gasdermin D

Nature Communications, 2019
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death.
K. Tsuchiya, S. Nakajima, S. Hosojima, Dinh Thi Nguyen, T. Hattori, Thuong Manh Le, O. Hori, M. Mahib, Y. Yamaguchi, M. Miura, T. Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, T. Shiroishi, T. Suda   +14 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Targeting RIPK1 kinase for modulating inflammation in human diseases

Frontiers in Immunology, 2023
Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase ...
Wanjin Li, Junying Yuan
doaj   +1 more source