Results 31 to 40 of about 580,743 (343)
Metalloporphyrins inactivate caspase-3 and -8 [PDF]
, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
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The role of cytochrome c in caspase activation in Drosophila melanogaster cells [PDF]
, 2002 The release of cytochrome c from mitochondria is necessary for the formation of the Apaf-1 apoptosome and subsequent activation of caspase-9 in mammalian cells.
Cakouros, Dimitrios +5 more
core +3 more sources
Raptor hunted by caspases [PDF]
Cell Death & Disease, 2016 Emergence of survival strategies is a key step for organisms during evolution. The capacity to adapt from nutrient-rich to nutrient-poor environments led to the appearance of protein complexes regulating anabolic and catabolic pathways. The evolutionarily conserved kinase mTOR (mechanistic target of rapamycin) emerged as a crucial and central protein ...
R Martin, M Thome, F Martinon, N Fasel
openaire +5 more sources
Armaghane Danesh Bimonthly Journal, 2022 Background & aim: Apoptosis induction is one of the basic goals in the production of anticancer drugs. Evaluation of the relationship between non-steroidal anti-inflammatory drugs (NSAID) and apoptosis in cancer cells is promising.
M Hashemzadeh, T Naji, R Ahmadi
doaj
TRAIL/Apo-2L: Mechanisms and Clinical Applications in Cancer
Neoplasia: An International Journal for Oncology Research, 2001 TNF-related apoptosis-inducing ligand (TRAIL/APO2L) is a member of the TNF family that promotes apoptosis by binding to the transmembrane receptors TRAIL-R1 /DR4 and TRAIL-R2/DR5.
Rakesh K. Srivastava
doaj +1 more source
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano +30 more
core +3 more sources
Molecules, 2020 The seeds of Millettia ferruginea are used in fishing, pesticides, and folk medicine in Ethiopia. Here, the anti-cancer effects of isoflavones isolated from M. ferruginea were evaluated in human ovarian cancer cells.
Yi-Yue Wang +5 more
doaj +1 more source
Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]
, 2009 The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele +8 more
core +1 more source
Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation [PDF]
, 2005 Pramanicin is a novel anti-fungal drug with a wide range of potential application against human diseases. It has been previously shown that pramanicin induces cell death and increases calcium levels in vascular endothelial cells. In the present study, we
Başağa, Hüveyda +3 more
core +1 more source
Caspase Activation by Anticancer Drugs: The Caspase Storm
Molecular Pharmaceutics, 2007 This study measures the time-dependence of cellular caspase activation by anticancer drugs and compares it with that of cellular respiration. Intracellular caspase activation and cellular respiration were measured during continuous exposure of Jurkat, HL-60, and HL-60/MX2 (deficient in topoisomerase-II) cells to dactinomycin, doxorubicin, and the ...
Tao, Zhimin +3 more
openaire +2 more sources