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Raptor hunted by caspases [PDF]
Cell Death & Disease, 2016 Emergence of survival strategies is a key step for organisms during evolution. The capacity to adapt from nutrient-rich to nutrient-poor environments led to the appearance of protein complexes regulating anabolic and catabolic pathways. The evolutionarily conserved kinase mTOR (mechanistic target of rapamycin) emerged as a crucial and central protein ...
R Martin, M Thome, F Martinon, N Fasel
openaire +5 more sources
Caspase Activation by Anticancer Drugs: The Caspase Storm
Molecular Pharmaceutics, 2007 This study measures the time-dependence of cellular caspase activation by anticancer drugs and compares it with that of cellular respiration. Intracellular caspase activation and cellular respiration were measured during continuous exposure of Jurkat, HL-60, and HL-60/MX2 (deficient in topoisomerase-II) cells to dactinomycin, doxorubicin, and the ...
Tao, Zhimin +3 more
openaire +2 more sources
Toxins, 2011 Ricin is a highly toxic type II ribosome-inactivating protein that has potential as a biochemical weapon and as the toxic component of immunotoxins. The unfolded protein response (UPR) is a survival response that helps cells to recover from endoplasmic ...
Wendie S. Cohick +3 more
doaj +1 more source
Nature Communications, 2019 Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Corey Rogers +5 more
semanticscholar +1 more source
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Science, 2020 Liver disease defect identified The energy sensor adenosine monophosphate–activated protein kinase (AMPK) is implicated in liver damage in nonalcoholic steatohepatitis (NASH), a leading cause of liver-associated death in humans. Zhao et al.
Peng Zhao +10 more
semanticscholar +1 more source
Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
Toxins, 2019 Garcinol, an anti-inflammatory and anti-carcinogenic polyisoprenylated benzophenone isolated from Garcinia plants, stimulates tumor cell apoptosis and suicidal erythrocyte death, but supports the survival of hepatocytes and neurons.
Hang Cao +8 more
doaj +1 more source
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Nature, 2009 The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about
V. Hornung +7 more
semanticscholar +1 more source
International Journal of Biochemistry and Cell Biology, 2020 Caspase-9 is a member of caspase family of cysteine proteases that have been implicated in apoptosis and cytokine processing. When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 ...
K. Kuida
semanticscholar +1 more source
Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma
Frontiers in Cell and Developmental BiologyGlaucoma is a complex disease of the optic nerve leading to vision loss and blindness, with high worldwide incidence and disproportionate prevalence in older populations.
Nisha Rajakrishna +9 more
doaj +1 more source
Guanylate-Binding Proteins (GBPs) convert cytosolic bacteria into caspase-4 signaling platforms
Nature Immunology, 2020 Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we
M. Wandel +11 more
semanticscholar +1 more source