Results 31 to 40 of about 572,919 (300)

Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]

, 2014
Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana, Becker, Christoph, Bleich, André, Buchen, Barbara, Gunther, Claudia, He, Gui-Wei, Hornef, Mathias, Martini, Eva, Neumann, Helmut, Neurath, Markus F., Torow, Natalia, Watson, Alastair J. M., Wittkopf, Nadine   +12 more
core   +3 more sources

Advances in research on the impact and mechanisms of pathogenic microorganism infections on pyroptosis

Frontiers in Microbiology
Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death characterized by the activation of gasdermin proteins, leading to the formation of pores in the cell membrane, continuous cell swelling, and eventual membrane rupture ...
Pan Shang, Pan Shang, Mailin Gan, Mailin Gan, Ziang Wei, Ziang Wei, Shijie Hu, Shijie Hu, Lei Song, Lei Song, Jinkang Feng, Jinkang Feng, Lei Chen, Lei Chen, Lili Niu, Lili Niu, Yan Wang, Yan Wang, Yan Wang, Shunhua Zhang, Shunhua Zhang, Linyuan Shen, Linyuan Shen, Linyuan Shen, Li Zhu, Li Zhu, Li Zhu, Ye Zhao, Ye Zhao, Ye Zhao   +29 more
doaj   +1 more source

Anti-Tumor Activity of Atractylenolide I in Human Colon Adenocarcinoma In Vitro

Molecules, 2020
Atractylodes macrocephala is known to exhibit multi-arrays of biologic activity in vitro. However, detail of its anti-tumor activity is lacking. In this study, the effects of atractylenolide I (AT-I), a bio-active compound present in Atractylodes ...
Ka Woon Karen Chan, Hau Yin Chung, Wing Shing Ho   +2 more
doaj   +1 more source

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]

, 2019
Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin, Brans, Toon, Declercq, Wim, Fraire, Juan, Raemdonck, Koen, Raes, Laurens, Roelandt, Ria, Saelens, Xavier, Stremersch, Stephan, Van Hoecke, Lien, Vandenabeele, Peter   +10 more
core   +2 more sources

Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

eLife
Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue – an essential consideration when developing effective methods to treat such ...
Jacob W Klemm, Chloe Van Hazel, Robin E Harris   +2 more
doaj   +1 more source

A Potential Mechanism for the Anti-Apoptotic Property of Koumine Involving Mitochondrial Pathway in LPS-Mediated RAW 264.7 Macrophages

Molecules, 2016
Koumine is a kind of alkaloid extracted from Gelsemium elegans (G. elegans). Benth, which has shown promise as an anti-tumor, anxiolytic, and analgesic agent. In our present study, the effect of koumine on lipopolysaccharide (LPS)-mediated RAW 264.7 cell
Zhi-Hang Yuan, Zeng-Enni Liang, Jing Wu, Jin-E Yi, Xiao-Jun Chen, Zhi-Liang Sun   +5 more
doaj   +1 more source

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]

, 2017
International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu, Dorn, Gerald W, II, Flavell, Richard A, Han, Qingqing, Hunot, Stephane, Masters, Seth L, Naderer, Thomas, Seidi, Azadeh, Speir, Mary, Vince, James E, Vogrin, Adam   +10 more
core   +4 more sources

Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication

Viruses, 2022
DNA damage response (DDR) is an evolutionarily conserved mechanism by which eukaryotic cells sense DNA lesions caused by intrinsic and extrinsic stimuli, including virus infection.
Xin Ming, Huan Chen, Ying Yang, Pu Zhao, Liumei Sun, Caisheng Zhang, Hyun-Jin Shin, Jeong-Soo Lee, Yong-Sam Jung, Yingjuan Qian   +9 more
doaj   +1 more source

IL-1R and inflammasomes mediate early pulmonary protective mechanisms in respiratory brucella abortus infection [PDF]

, 2016
Brucella spp. infection is frequently acquired through contaminated aerosols. The role of interleukin-1 beta (IL-1β) in the early pulmonary response to respiratory Brucella infection is unknown.
Alonso Paiva, Iván Mathias, Baldi, Pablo Cesar, Campos, Priscila C., Falivene, Juliana, Fernandez, Andrea Giselle, Ferrero, Mariana Cristina, Hielpos, María Soledad, Muñoz González, Florencia, Oliveira, Sergio Costa, Vieira, Angelica T.   +9 more
core   +1 more source

Inflammasomes and idiopathic inflammatory myopathies

Frontiers in Immunology
Idiopathic inflammatory myopathies (IIM) are a group of systemic autoimmune diseases characterized by muscle weakness and elevated serum creatine kinase levels.
Rui Sun, Jiyan Chu, Jiyan Chu, Ping Li
doaj   +1 more source