Results 271 to 280 of about 24,063,457 (338)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata. [PDF]

Biomol Biomed
Zhang J, Li Z, Liu K, Du X, Yao T, Ye J.
europepmc   +1 more source

Expression and activity of caspases 1 and 3 in myelodysplastic syndromes

, 2000
Delphine Boudard, Olivier Sordet, C. Vasselon, Valérie Revol, M. F. Bertheas, Damien Freyssenet, Annie Viallet, S PISELLI, Denis Guyotat, Lydia Campos   +9 more
openalex   +1 more source

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Cell Death and Differentiation, 2015
V. Kaushal, V. Kaushal, Rebecca Dye, Prateep Pakavathkumar, Prateep Pakavathkumar, B. Foveau, B. Foveau, Joseph Flores, Joseph Flores, B. Hyman, B. Ghetti, B. Koller, A. LeBlanc, A. LeBlanc   +13 more
semanticscholar   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

Advanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan, Yunxuan Wang, Xufan Deng, Shiyu Wu, Yifan Pan, Jun Du, Mei Yu, Bo Liu, Huimei Wang, Zhengyu Zhang, Jinghong Chen, Shuifa Chen, Yizheng Wang, Tara Walker, Perry Bartlett, Jun Ju, Sheng‐Tao Hou   +16 more
wiley   +1 more source

Correction to "Adipose Tissue IL-18 Production Is Independent of Caspase-1 and Caspase-11". [PDF]

Immun Inflamm Dis
europepmc   +1 more source

Caspase-1-dependent spatiality in triple-negative breast cancer and response to immunotherapy. [PDF]

Nat Commun
Zheng W, Marini W, Murakami K, Sotov V, Butler M, Gorrini C, Ohashi PS, Reedijk M.   +7 more
europepmc   +1 more source

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux

Journal of Immunology, 2015
Mausita Karmakar, Michael A. Katsnelson, H. Malak, Neil G. Greene, S. Howell, A. Hise, A. Camilli, A. Kadioglu, G. Dubyak, E. Pearlman   +9 more
semanticscholar   +1 more source

Local Visible‐Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer

Advanced Science, EarlyView.
A novel concept of visible‐photocatalytic hydrogen/warm heat production is proposed for combination treatment of pressure ulcer (PU), and develop a new kind of palladium nanodots‐deposited hydrogen‐doped titanium dioxide nanorods encapsulating hydorgel dressing to receive a high outcome of PU treatment by hydrogen/warm heat synergistically improving ...
Jiawei Zhu, Ting Chen, Wei Fang, Di Zhou, Dalong Ni, Bin Zhao, Yali Yang, Zhuobin Xu, Qianjun He   +8 more
wiley   +1 more source

Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway. [PDF]

Front Pharmacol
An N, Wang X, Qin J, Cheng M, Bai M, Cheng J, Xu Q, Wu X.   +7 more
europepmc   +1 more source