Results 21 to 30 of about 24,421,742 (361)
Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk [PDF]
Circulation Research, 2006 Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag
Blankenberg, S. +15 more
openaire +3 more sources
eLife, 2023 Potassium efflux via the two-pore K+ channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K+ efflux is activated in response to select cues.
Long Shuang Huang +7 more
doaj +1 more source
PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway
Environmental Toxicology, 2020 Particulate matter 2.5 (PM2.5)‐induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase‐1 pathway was closely related to the inflammatory response of various diseases.
Hui Jia +5 more
semanticscholar +1 more source
Viruses, 2021 The success of long-term host–virus partnerships is predicated on the ability of the host to limit the destructive potential of the virus and the virus’s skill in manipulating its host to persist undetected yet replicate efficiently when needed.
Sumita Bhaduri-McIntosh +1 more
doaj +1 more source
Caspase-1 interdomain linker cleavage is required for pyroptosis
Life Science Alliance, 2020 The related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis. Pathogen-related signals induce a number of cytosolic
D. Ball +8 more
semanticscholar +1 more source
RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]
Journal of Biological Chemistry, 2009 Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Christine Becker +2 more
openaire +5 more sources
Pathogens, 2020 Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson +13 more
doaj +1 more source
Caspase-1 activation of caspase-6 in human apoptotic neurons [PDF]
Cell Death & Differentiation, 2005 Active caspase-6 (Csp-6) induces cell death in primary cultures of human neurons and is abundant in the neuropathological lesions of Alzheimer's disease. However, the mode of Csp-6 activation is not known. Here, we show that the Csp-1 inhibitor, Z-YVAD-fmk specifically prevents activation of Csp-6 and cell death in human neurons.
D Pétrin +7 more
openaire +3 more sources
Life Science Alliance, 2020 Caspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.
Rosalie Heilig +7 more
semanticscholar +1 more source
Korean Journal of Clinical Laboratory Science, 2021 Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung +3 more
doaj +1 more source