Results 21 to 30 of about 24,258,002 (357)

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Cell Reports, 2021
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant   +13 more
doaj   +1 more source

Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk [PDF]

Circulation Research, 2006
Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag
Blankenberg, S., Godefroy, T., Poirier, O., Rupprecht, H.J., Barbaux, S., Bickel, C., Nicaud, V., Schnabel, R., Kee, Frank, Morrison, C., Evans, Alun, Lackner, K.J., Cambien, F., Munzel, T., Tiret, L., Investigators, AtheroGene   +15 more
openaire   +3 more sources

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

Cancers, 2020
Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation ...
Jin-Feng Teng, Q. Mei, Xiaogang Zhou, Yong Tang, R. Xiong, Wenqiao Qiu, Rong Pan, B. Law, V. Wong, Chong-Lin Yu, Han-an Long, Xiu-Li Xiao, Feng Zhang, Jianming Wu, Da-Lian Qin, Anguo Wu   +15 more
semanticscholar   +1 more source

Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts

Frontiers in Immunology, 2020
Sepsis/endotoxemia activates the NLRP3 inflammasome of macrophages leading to the maturation and release of IL-1β, an important mediator of the inflammatory response. Reactive oxygen species have been implicated in NLRP3 inflammasome activation. Further,
Ting Lan, Ting Lan, Ting Lan, Aibin Tao, Aibin Tao, Xuemei Xu, Xuemei Xu, Peter Kvietys, Tao Rui, Tao Rui, Tao Rui, Tao Rui   +11 more
doaj   +1 more source

Acute Circadian Disruption Due to Constant Light Promotes Caspase 1 Activation in the Mouse Hippocampus

Cells, 2023
In mammals, the circadian system controls various physiological processes to maintain metabolism, behavior, and immune function during a daily 24 h cycle.
Pikria Ketelauri, Katerina Scharov, Charlotte von Gall, Sonja Johann   +3 more
doaj   +1 more source

PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway

Environmental Toxicology, 2020
Particulate matter 2.5 (PM2.5)‐induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase‐1 pathway was closely related to the inflammatory response of various diseases.
Hui Jia, Yang Liu, Dandan Guo, Wei He, Long Zhao, Shuyue Xia   +5 more
semanticscholar   +1 more source

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]

Journal of Biological Chemistry, 2009
Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Christine Becker, Emma M. Creagh, Luke A. J. O'Neill   +2 more
openaire   +5 more sources

Caspase-1 activation of caspase-6 in human apoptotic neurons [PDF]

Cell Death & Differentiation, 2005
Active caspase-6 (Csp-6) induces cell death in primary cultures of human neurons and is abundant in the neuropathological lesions of Alzheimer's disease. However, the mode of Csp-6 activation is not known. Here, we show that the Csp-1 inhibitor, Z-YVAD-fmk specifically prevents activation of Csp-6 and cell death in human neurons.
D Pétrin, Andréa C. LeBlanc, Andréa C. LeBlanc, Yan Zhang, Yan Zhang, Catherine Bergeron, Cynthia G. Goodyer, H Guo   +7 more
openaire   +3 more sources

Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway

Open Life Sciences, 2020
This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury.
Mai Zhen-Hao, Huang Yu, Huang Di, Huang Zi-Sheng, He Zhi-Xiang, Li Pei-Lin, Zhang Shuai, Weng Jie-Feng, Gu Wei-Li   +8 more
doaj   +1 more source

Caspase-1 interdomain linker cleavage is required for pyroptosis

Life Science Alliance, 2020
The related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis. Pathogen-related signals induce a number of cytosolic
D. Ball, Cornelius Y. Taabazuing, A. R. Griswold, E. L. Orth, Sahana D. Rao, Ilana B. Kotliar, Lauren E Vostal, Darren C. Johnson, D. Bachovchin   +8 more
semanticscholar   +1 more source