Results 21 to 30 of about 24,233,392 (378)
Caspase-1 and Caspase-8 Cleave and Inactivate Cellular Parkin [PDF]
Journal of Biological Chemistry, 2003 Lesions in the parkin gene cause early onset Parkinson's disease by a loss of dopaminergic neurons, thus demonstrating a vital role for parkin in the survival of these neurons. Parkin is inactivated by caspase cleavage, and the major cleavage site is after Asp126.
Kahns, Søren +5 more
openaire +5 more sources
Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk [PDF]
Circulation Research, 2006 Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag
Blankenberg, S. +15 more
openaire +3 more sources
Cancers, 2020 Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation ...
Jin-Feng Teng +15 more
semanticscholar +1 more source
A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages
Cells, 2023 Inflammation and mitochondrial-dependent oxidative stress are interrelated processes implicated in multiple neuroinflammatory disorders, including Alzheimer’s disease (AD) and depression.
Simmie L. Foster +8 more
doaj +1 more source
PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway
Environmental Toxicology, 2020 Particulate matter 2.5 (PM2.5)‐induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase‐1 pathway was closely related to the inflammatory response of various diseases.
Hui Jia +5 more
semanticscholar +1 more source
RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. [PDF]
Journal of Biological Chemistry, 2009 Interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic THP1 cell line, we identified previously undescribed binding partners using mass spectrometry.
Christine Becker +2 more
openaire +5 more sources
Caspase-1 activation of caspase-6 in human apoptotic neurons [PDF]
Cell Death & Differentiation, 2005 Active caspase-6 (Csp-6) induces cell death in primary cultures of human neurons and is abundant in the neuropathological lesions of Alzheimer's disease. However, the mode of Csp-6 activation is not known. Here, we show that the Csp-1 inhibitor, Z-YVAD-fmk specifically prevents activation of Csp-6 and cell death in human neurons.
D Pétrin +7 more
openaire +3 more sources
Pathogens, 2020 Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson +13 more
doaj +1 more source
Caspase-1 interdomain linker cleavage is required for pyroptosis
Life Science Alliance, 2020 The related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis. Pathogen-related signals induce a number of cytosolic
D. Ball +8 more
semanticscholar +1 more source
Korean Journal of Clinical Laboratory Science, 2021 Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis.
Byung Chul Jung +3 more
doaj +1 more source