Results 41 to 50 of about 24,421,742 (361)
Investigation of the cellular response to bone fractures: evidence for flexoelectricity [PDF]
Scientific Reports volume 10, Article number: 254 (2020), 2020 The recent discovery of bone flexoelectricity (electrical polarization induced by strain gradient) suggests that flexoelectricity could have physiological effects in bones, and specifically near bone fractures, where flexoelectricity is theoretically highest. Here, we report a cytological study of the interaction between crack stress and bone cells. We
arxiv +1 more source
GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages
Frontiers in Cellular and Infection Microbiology, 2023 Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang +10 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 Oomycete, particularly Phytophthora species, causes the most devastating crop diseases, such as potato late blight, and threatens the sustainable crop production worldwide. Our previous studies identified Resistance to Phytophthora parasitica 1 (RTP1) as
Xian-xian GAO +6 more
doaj
Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
doaj +1 more source
Caspase-1 initiates apoptosis in the absence of gasdermin D
Nature Communications, 2019 Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death.
K. Tsuchiya +14 more
semanticscholar +1 more source
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 [PDF]
Nature, 2012 Inflammasomes are cytosolic multiprotein complexes assembled by intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and they initiate innate immune responses to invading pathogens and danger signals by activating caspase-1 (ref. 1).
Broz, Petr +6 more
openaire +4 more sources
Indian Journal of Animal Sciences, 2022 The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY +2 more
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Thalidomide Inhibits Activation of Caspase-1 [PDF]
The Journal of Immunology, 2009 Abstract Thalidomide is an efficient anti-inflammatory and anti-angiogenic drug, but its therapeutic use is problematic due to a strong teratogenic activity. Nevertheless, thalidomide was approved for the treatment of inflammatory skin diseases and certain types of cancer, and it is extensively tested for several other indications ...
Hans-Dietmar Beer +2 more
openaire +3 more sources
Cells, 2022 The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget +3 more
doaj +1 more source
Kinetic Monte Carlo study of the type1/type 2 choice in apoptosis elucidates selective killing of cancer cells under death ligand induction [PDF]
OJApo 4 (2015) 22-39, 2015 Death ligand mediated apoptotic activation is a mode of programmed cell death that is widely used in cellular and physiological situations. Interest in studying death ligand induced apoptosis has increased due to the promising role of recombinant soluble forms of death ligands (mainly recombinant TRAIL) in anti-cancer therapy.
arxiv +1 more source