Results 41 to 50 of about 24,258,002 (357)
Obesity Science & Practice, 2023 Mechanisms underlying the negative effects of obesity on the brain are still unknown. Obesity is associated with oxidative stress in the brain and neuroinflammation that promotes neurodegenerative diseases.
Erick Gómez‐Apo +4 more
doaj +1 more source
Caspase-1 initiates apoptosis in the absence of gasdermin D
Nature Communications, 2019 Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death.
K. Tsuchiya +14 more
semanticscholar +1 more source
GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages
Frontiers in Cellular and Infection Microbiology, 2023 Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang +10 more
doaj +1 more source
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 [PDF]
Nature, 2012 Inflammasomes are cytosolic multiprotein complexes assembled by intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and they initiate innate immune responses to invading pathogens and danger signals by activating caspase-1 (ref. 1).
Broz, Petr +6 more
openaire +4 more sources
Journal of Lipid Research, 2015 Cholesterol crystals form within hepatocyte lipid droplets in human and experimental nonalcoholic steatohepatitis (NASH) and are the focus of crown-like structures (CLSs) of activated Kupffer cells (KCs).
George N. Ioannou +6 more
doaj +1 more source
Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
doaj +1 more source
Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP [PDF]
Journal of Biological Chemistry, 2003 The apoptosome is a multiprotein complex comprising Apaf-1, cytochrome c, and caspase-9 that functions to activate caspase-3 downstream of mitochondria in response to apoptotic signals. Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a ...
Junshan Hao +8 more
openaire +3 more sources
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Journal of Experimental Medicine, 2018 Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but mechanisms controlling the duration of cellular caspase-1 activity are unknown.
D. Boucher +12 more
semanticscholar +1 more source
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Reports, 2020 Summary: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death ...
Nathalia Moraes de Vasconcelos +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The pore-forming protein gasdermin D (GSDMD) was recently identified as the principal executioner of pyroptosis (“fiery death”), a type of proinflammatory programmed cell death driven by inflammasomes.
Brienne A. McKenzie +8 more
semanticscholar +1 more source