Results 41 to 50 of about 509,167 (309)

Probiotics Improve Cognitive Impairment by Decreasing Bacteria-Related Pattern Recognition Receptor-Mediated Inflammation in the Gut-Brain Axis of Mice

Journal of Integrative Neuroscience, 2023
Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported.
Xue-Qin Yang, Yang Zhao, Li Xue, Hui-Shan Wang, Jia Zeng, Jun-Rong Du, Zhe Xu   +6 more
doaj   +1 more source

Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]

, 2008
A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González, Chittaranjan, Suganthi, Gorski, Sharon M., Hou, Ying-Chen Claire, McCall, Kimberly   +4 more
core   +4 more sources

Apoptotic gene expression in neuropathic pain [PDF]

, 2008
Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system and is associated with several clinical symptoms ...
Annalucia Migliozzi, Carlo Fuccio, Catia Giordano, Dario Siniscalco, Francesco Rossi, Livio Luongo, Sabatino Maione   +6 more
core   +2 more sources

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease [PDF]

, 2017
Rabies virus is a highly neurovirulent RNA virus, which causes about 59000 deaths in humans each year. Previously, we described macrophage cytotoxicity upon infection with rabies virus.
Beyaert, Rudi, Francart, A, Kalai, M, Kip, Elodie, Lamoral, S, Nazé, F, Suin, V, Van Gucht, Steven, Vanden Berghe, Tom, Vandenabeele, Peter   +9 more
core   +2 more sources

ASC/inflammasome-independent pyroptosis in ovarian cancer cells through translational augmentation of caspase-1

iScience, 2023
Summary: Canonical pyroptosis is type of programmed cell death depending on active caspase-1, and the inflammasome carries out caspase-1 activation. Here, we showed that docosahexaenoic acid (DHA) induced ovarian cancer cell deaths in caspase-1-dependent
Ozlem Calbay, Ravi Padia, Mahmuda Akter, Lei Sun, Bin Li, Nicole Qian, Jianhui Guo, Zheng Fu, Lingtao Jin, Shuang Huang   +9 more
doaj   +1 more source

Pseudomonas aeruginosa pilin activates the inflammasome [PDF]

, 2011
IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4.
Agostini, Andersen-Nissen, Arora, Auron, Bergsbaken, Bird, Bitter, Case, Choi, Cornelis, Craig, Dinarello, Evans, Franchi, Franchi, Franchi, Hahn, Hazes, Hsu, Johnson, Kanneganti, Kus, Lightfield, Lindestam Arlehamn, Liu, Marathe, Mariathasan, Mariathasan, Martinon, Martinon, Mattick, Miao, Miao, Miao, Murray, Muruve, Neyt, O'Neill, Perkins, Pier, Proft, Sato, Sato, Sawa, Schroeder, Semmler, Smedley, Sutterwala, Sutterwala, Thornberry, Ting, Vallis, von Götz, Ye, Yu   +54 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential [PDF]

, 2015
Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis.
Caiazza, F, Creagh, EM, Doherty, GA, Fay, J, Flood, B, Heetun, Z, Kay, E, Laukens, Debby, Mills, KHG, O'Grady, A, Oficjalska, K, Ryan, EJ, Sheahan, K   +12 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Molecular mechanism of adipose tissue inflammation induced by acute exposure to cooking oil fumes

环境与职业医学
BackgroundCooking oil fumes are closely related to immune response, and adipose tissue also plays an important role in immune regulation. At present, the biological effect and mechanism of inflammation of adipose tissue induced by oil fume exposure are ...
Ge WANG, Biao WU, Jianshu GUO, Dongxia FAN, Lu YU, Chihang ZHANG, Lan MI, Lina WANG, Jinzhuo ZHAO   +8 more
doaj   +1 more source