Results 61 to 70 of about 24,258,002 (357)
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis
EMBO Journal, 2018 Viral infection triggers host innate immune responses, which primarily include the activation of type I interferon (IFN) signaling and inflammasomes.
Yanyan Zheng +9 more
semanticscholar +1 more source
Caspase‐1‐induced pyroptotic cell death [PDF]
Immunological Reviews, 2011 Summary: Programmed cell death is a necessary part of development and tissue homeostasis enabling the removal of unwanted cells. In the setting of infectious disease, cells that have been commandeered by microbial pathogens become detrimental to the host. When macrophages and dendritic cells are compromised in this way, they can be lysed by pyroptosis,
Edward A. Miao +3 more
openaire +2 more sources
Journal of Integrative Neuroscience, 2023 Introduction: Some studies have found that probiotics can improve cognitive impairment in Alzheimer’s disease, although the specific molecular mechanism by which this occurs has not been reported.
Xue-Qin Yang +6 more
doaj +1 more source
Inflammation, 2018 Sepsis-associated encephalopathy (SAE) is a common complication that leads to long-term cognitive impairments and increased mortality in sepsis survivors. The mechanisms underlying this complication remain unclear and an effective intervention is lacking.
Qun Fu +8 more
semanticscholar +1 more source
iScience, 2023 Summary: Canonical pyroptosis is type of programmed cell death depending on active caspase-1, and the inflammasome carries out caspase-1 activation. Here, we showed that docosahexaenoic acid (DHA) induced ovarian cancer cell deaths in caspase-1-dependent
Ozlem Calbay +9 more
doaj +1 more source
Modulation of nucleobindin‐1 and nucleobindin‐2 by caspases [PDF]
FEBS Letters, 2007 Nucleobindin‐1 (NUCB1) and nucleobindin‐2 (NUCB2) are multifunctional proteins that interact with Ca2+, nucleic acids and various regulatory proteins in different signaling pathways. So far, our understanding of the regulation of the biological functions of nucleobindins remains limited. In our proteome‐wide selection for downstream caspase substrates,
Steven W. Cotten +3 more
openaire +3 more sources
Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
Journal of Neuroinflammation, 2018 Traumatic brain injury (TBI) is a critical public health and socioeconomic problem throughout the world. Inflammation-induced secondary injury is one of the vital pathogenic parameters of TBI.
Wei Liu +7 more
semanticscholar +1 more source
Role of Caspase 1 in Neurologic Disease [PDF]
Archives of Neurology, 2000 In recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in a variety of neurologic diseases. Since the central nervous system (CNS) has little, if any, power of functional neuronal regeneration, prevention of neuronal cell death is an important target of modern neurotherapeutics.
openaire +3 more sources
Caspase‐1 is not involved in experimental hepatitis in mouse [PDF]
FEBS Letters, 1999 Experimental hepatitis induced by tumor necrosis factor in d‐(+)‐galactosamine‐sensitized mice or by an agonistic anti‐Fas antibody in normal mice is accompanied by dramatic apoptosis of hepatocytes. Apoptosis is the final result of activation of a cascade of caspases.
Peter Brouckaert +2 more
openaire +3 more sources
Caspase-1 and Caspase-11 Mediate Pyroptosis, Inflammation, and Control of Brucella Joint Infection
Infection and Immunity, 2018 Brucellosis, caused by the intracellular bacterial pathogen Brucella, is a zoonotic disease for which arthritis is the most common focal complication in humans.
Carolyn A. Lacey +3 more
semanticscholar +1 more source