Results 61 to 70 of about 24,233,392 (378)
Indian Journal of Animal Sciences, 2022 The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY +2 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The pore-forming protein gasdermin D (GSDMD) was recently identified as the principal executioner of pyroptosis (“fiery death”), a type of proinflammatory programmed cell death driven by inflammasomes.
Brienne A. McKenzie +8 more
semanticscholar +1 more source
Caspase-1: is IL-1 just the tip of the ICEberg? [PDF]
Cell Death & Disease, 2012 Caspase-1, formerly known as interleukin (IL)-1-converting enzyme is best established as the protease responsible for the processing of the key pro-inflammatory cytokine IL-1β from an inactive precursor to an active, secreted molecule. Thus, caspase-1 is regarded as a key mediator of inflammatory processes, and has become synonymous with inflammation ...
Denes, A. +2 more
openaire +3 more sources
Cells, 2022 The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget +3 more
doaj +1 more source
Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
core +2 more sources
Caspase-1 as a regulatory molecule of lipid metabolism [PDF]
Lipids in Health and Disease, 2020 AbstractCaspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18).
Tesfahun Dessale Admasu +4 more
openaire +3 more sources
Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes. [PDF]
, 2015 Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats (P2) and adult Balb/C mice.
Choe, Seong-Kyu +11 more
core +2 more sources
Cell Death and Disease, 2019 Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system.
Lingbin Sun +7 more
semanticscholar +1 more source
Caspase-1ζ, a new splice variant of the caspase-1 gene
Genomics, 2004 Five alternatively spliced mRNA isoforms of human caspase-1 have been identified previously and we report here the cloning of a new isoform, named CASP1 zeta (zeta), from human ovarian surface epithelial cell cDNA. The new isoform zeta is identical to the alpha isoform but missing 79 nucleotides in the coding region of the prodomain of procaspase-1 ...
Peter C.K. Leung +3 more
openaire +3 more sources
Caspase-1 inflammasomes in infection and inflammation [PDF]
Journal of Leukocyte Biology, 2007 AbstractNucleotide-binding and oligomerization domain-like receptors (NLRs) constitute a family of germline-encoded pattern-recognition receptors, which allow the host to respond rapidly to a wide variety of pathogenic microorganisms. Here, we discuss recent advances in the study of a subset of NLRs, which control the activation of caspase-1 through ...
Lamkanfi, Mohamed +3 more
openaire +4 more sources