Results 31 to 40 of about 17,150,662 (399)

Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious   challenge as a result.
Sarah Saad Hamdan, Yassir Mustafa Kamal, Huda Jaber Waheed   +2 more
doaj   +1 more source

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

Cell Death and Disease, 2020
Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer membrane permeabilization (MOMP), which induces the activation of pro-apoptotic caspase cascade.
Lei Hu, Meng Chen, Xueran Chen, Chenggang Zhao, Zhiyou Fang, Hongzhi Wang, Haiming Dai   +6 more
semanticscholar   +1 more source

Executioner caspase-3 and caspase-7 are functionally distinct proteases [PDF]

Proceedings of the National Academy of Sciences, 2008
Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major executioner caspases, caspase-3 and caspase-7, exhibit almost indistinguishable activity toward certain synthetic peptide substrates, this has led to the widespread view that these ...
Alexander U. Lüthi, Clare Sheridan, Christopher Gerner, John G. Walsh, Sean P. Cullen, Seamus J. Martin   +5 more
openaire   +3 more sources

Tau and Caspase 3 as Targets for Neuroprotection [PDF]

International Journal of Alzheimer's Disease, 2012
The peptide drug candidate NAP (davunetide) has demonstrated protective effects in variousin vivoandin vitromodels of neurodegeneration. NAP was shown to reduce tau hyperphosphorylation as well as to prevent caspase-3 activation and cytochrome-3 release from mitochondria, both characteristic of apoptotic cell death. Recent studies suggest that caspases
Anat Idan-Feldman, Regina Ostritsky, Illana Gozes   +2 more
openaire   +3 more sources

A non-apoptotic role for caspase-9 in muscle differentiation [PDF]

, 2008
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O, Howley, Breege A, McMahon, Jill M, Mohr, Andrea, Murray, Thomas VA, Ritter, Thomas, Stanley, Alanna, Zwacka, Ralf   +7 more
core   +1 more source

CD34 e caspase-3: comparação, correlação de expressão e quantificação imunoistoquímica no adenocarcinoma gástrico CD34 and caspase-3: expression, quantification comparison and correlation in gastric adenocarcinoma

ABCD: Arquivos Brasileiros de Cirurgia Digestiva, 2008
RACIONAL: O câncer gástrico continua a desafiar a medicina moderna a compreender o seu comportamento biológico e a melhorar seus índices de cura cirúrgica e taxa de sobrevivência.
Paulo Henrique Freitas Farias Silva, Ronaldo Mafia Cuenca, Jurandir Marcondes Ribas-Filho, Carmen Australia Paredes Marcondes Ribas, Osvaldo Malafaia, Samuel Dobrowolski, Fabio Roberto Bora   +6 more
doaj   +1 more source

Local anaesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro [PDF]

, 2016
Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms.
Chen, L, Hankin, J, Ma, D, Xuan, W, Yao, S, Zhao, H   +5 more
core   +5 more sources

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano, AM Verhagen, B Joseph, B Joseph, BP Eckelman, C Du, D Conte, DW Nicholson, E Varfolomeev, H Durkop, H Huang, JE Vince, JL Venero, K Rajalingam, K Saijo, K Saijo, M D'Amelio, M Gyrd-Hansen, M Luo, MA Burguillos, ML Block, N Muller-Sienerth, OH Voss, PL McGeer, S Kamada, SP Burke, ST Beug, T Tenev, V Bocchini, X Cui, Z Han   +30 more
core   +3 more sources

Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3 [PDF]

Journal of Biological Chemistry, 2013
Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively. Interestingly, caspase-1 cleaves far fewer cellular substrates than caspase-3 and also shows strong positive cooperativity ...
Datta, Debajyoti, McClendon, Christopher L, Jacobson, Matthew P, Wells, James A   +3 more
openaire   +5 more sources

Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source