Results 51 to 60 of about 530,883 (357)
Plasma, 2022 Current methods used to treat non-muscle invasive bladder cancer are inadequate due to a high recurrence rate after surgery and the occurrence of adverse events such as interstitial pneumonia following intravesical instillation therapy.
Hideo Fukuhara +12 more
doaj +1 more source
Immunohistochemical Expression of Caspase 3 in Psoriasis
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2017 Psoriasis is a persistent chronic immune-mediated, relapsing, inflammatory and hyper proliferative skin disorder with genetic predisposition. Psoriasis can be considered as a T-cell mediated disease, with a complex role for a variety of cytokine interaction between keratinocytes and T-lymphocytes.
Dina Ragab Afify +3 more
openaire +4 more sources
Galactose:PEGamine coated gold nanoparticles adhere to filopodia and cause extrinsic apoptosis [PDF]
, 2018 Ultra-small gold nanoparticles, surface functionalised with a 50:50 ratio of a thiolated α-Galactose derivative and a thiolated hexaethylene glycol amine, are toxic to HSC-3 oral squamous carcinoma cells.
Espinosa Garcia, Cristina +3 more
core +1 more source
Conversion of Procaspase-3 to an Autoactivating Caspase by Fusion to the Caspase-2 Prodomain [PDF]
Journal of Biological Chemistry, 1998 Caspases are cysteine proteases that play an essential role in apoptosis. Initial activation of caspases defines the key step in apoptotic execution. Based on primary structure, caspases can be divided into two groups, those with long amino-terminal prodomains (class I), and those with relatively short prodomains (class II).
Colussi, P. +3 more
openaire +4 more sources
Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy [PDF]
, 2015 Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect.
Comlekci, S. +5 more
core +1 more source
The prodomain of caspase-3 regulates its own removal and caspase activation [PDF]
Cell Death Discovery, 2019 AbstractCaspase-3 is a cysteine–aspartic acid protease that cleaves cellular targets and executes cell death. Our current understanding is caspase-3 is activated by the cleavage of the interdomain linker and then subsequent cleavage of the N-terminal prodomain.
Lawrence H. Boise, Katelyn G Ponder
openaire +3 more sources
TRAIL, DR5 and Caspase 3-dependent Apoptosis in Vessels of Diseased Human Temporomandibular Joint Disc. An Immunohistochemical Study [PDF]
, 2010 To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ) degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase
Almeida, Luis Eduardo +4 more
core +4 more sources
Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study.
Histology and histopathology, 2006 Caspases are the main point in the apoptotic process. We have collected some information from 210 cases of Ductal breast cancer (pT1 - pT2) such as tumour size, histological differentiation degree, lymph node status and tumor necrosis in the infiltrating component and we have evaluated the number of apoptotic cells or bodies by TUNEL technique as well ...
Blázquez, S. +6 more
openaire +3 more sources
Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]
Journal of Molecular Biology, 2018 Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya +4 more
openaire +4 more sources
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis [PDF]
BMC Cell Biology, 2013 AbstractBackgroundApoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochromecrelease is well described; however the distinct roles of caspases-9, -3 and -7 during this process are not completely defined.ResultsHere we ...
Lawrence H. Boise +5 more
openaire +3 more sources