Results 51 to 60 of about 16,798,464 (375)
Overexpression of caspase-3 in hepatocellular carcinomas [PDF]
Modern Pathology, 2004 Caspase-3 is a downstream effector cysteine protease in the apoptotic pathway. It is ubiquitously expressed in normal human tissues including the liver. Overexpression and loss of expression of caspase-3 has been reported in diverse human malignancies. However, expression of caspase-3 in hepatocellular carcinoma (HCC) has not been studied.
Rajendra Persad +6 more
openaire +2 more sources
Analysis Expression of ZIP1 and Caspase-3 Protein in Adenocarsinoma of the Prostate [PDF]
, 2016 Background: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells. Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit apoptosis,
Kodariah, R. (Ria) +2 more
core +3 more sources
Huntingtin inhibits caspase-3 activation [PDF]
The EMBO Journal, 2006 Huntington's disease results from a mutation in the HD gene encoding for the protein huntingtin. The function of huntingtin, although beginning to be elucidated, remains largely unclear. To probe the prosurvival function of huntingtin, we modulate levels of wild-type huntingtin in a number of cellular and in vivo models.
Ioannis Dragatsis +7 more
openaire +3 more sources
Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer [PDF]
, 2018 Background: Effective anticancer therapy is thought to involve induction of tumour cell death through apoptosis and/or necrosis. [18F]ICMT-11, an isatin sulfonamide caspase-3/7-specific radiotracer, has been developed for PET imaging and shown to have ...
Aboagye, Eric O. +16 more
core +1 more source
An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells
Biotechnology Reports, 2015 The effects of reactive oxygen species on cells have attracted great attention from both physiological and pathological aspects. Superoxide (O2−) is the primary reactive oxygen species formed in animals.
Minoru Tamura +5 more
doaj +1 more source
Definitions, 2020 Caspase-3 (277 aa, ~31 kDa) is encoded by the human CASP3 gene. This protein is involved in the mediation of proteolysis and the activation of apoptosis.
semanticscholar +1 more source
Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells
Oncotarget, 2014 Signal Transducer and Activator of Transcription-1 (STAT1) is phosphorylated upon interferon (IFN) stimulation, which can restrict cell proliferation and survival. Nevertheless, in some cancers STAT1 can act in an anti-apoptotic manner. Moreover, certain malignancies are characterized by the overexpression and constitutive activation of STAT1. Here, we
Verena Licht +7 more
openaire +4 more sources
Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation [PDF]
, 2005 Pramanicin is a novel anti-fungal drug with a wide range of potential application against human diseases. It has been previously shown that pramanicin induces cell death and increases calcium levels in vascular endothelial cells. In the present study, we
Başağa, Hüveyda +3 more
core +1 more source
Caspase-3 joins the p53 interactome [PDF]
Cancer Biology & Therapy, 2011 Commentary to: Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Amanda K. Frank, E.
Klaus Roemer, Kristina Heyne
openaire +3 more sources
Frontiers in Pharmacology, 2020 Quinazoline derivatives display multiple pharmacological activities and target various biological receptors. Based on the skeleton of quinazoline core, we designed and synthesized three new quinazoline-phenyl chlormethine conjugates (I–III) bearing a ...
Jia-jia Lv +14 more
doaj +1 more source