Results 81 to 90 of about 17,150,662 (399)

Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3 [PDF]

, 2010
The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms
A. Maldonado-Contreras, B. A. McCormick, Barthel, C. V. Srikanth, Cherayil, Chiu, D. M. Wall, D. Zhou, Deane, H. N. Shi, Hueck, K. L. Mumy, Kim, Lee, Lee, Lee, Lilic, McCormick, McCormick, Nhan, Ohlson, Ramarao, Tran Van Nhieu, Wall, Wood, Z. Demma, Zakeri, Zhang, Zhou   +28 more
core   +1 more source

Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP [PDF]

Journal of Biological Chemistry, 2003
The apoptosome is a multiprotein complex comprising Apaf-1, cytochrome c, and caspase-9 that functions to activate caspase-3 downstream of mitochondria in response to apoptotic signals. Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a ...
Junshan Hao, Jean Wang, Ruomei Yang, Robert C. Armstrong, Kevin J. Tomaselli, Hua Zou, Stephen W. Fesik, Chaohong Sun, Joe C. Wu   +8 more
openaire   +3 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Synthesis of a New ent-Cyclozonarone Angular Analog, and Comparison of Its Cytotoxicity and Apoptotic Effects with ent-Cyclozonarone

Molecules, 2013
The synthesis of a newangular analog 11 of cyclozonarone was achieved via Diels-Alder reaction between a sesquiterpene-1,3-diene and 1,4-benzoquinone. The cytotoxic activity of ent-cyclozonarone [(+)-10] and the angular (−)-cyclozonarone analog 11 has ...
Mauricio Cuellar Fritis, Valentina Ulloa Valdivia, Joan Villena García, Cristóbal Carrasco Rojas, Luis Espinoza Catalán, Cristian Salas Sánchez, Iván Montenegro Venegas, Natalia Quiñones Sobarzo   +7 more
doaj   +1 more source

Effect of sikkam (Bischofia javanica Blume) ethanolic extract on the quality and quantity of hyperglycemic rat sperm [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Hyperglycemia causes diabetes mellitus (DM), abnormal metabolism, oxidative stress, and chronic complications such as impotence. Hyperglycemia causes testicular atrophy and stromal cell, seminiferous tubular damage, and spermatogenic cells ...
Syafruddin Ilyas, Salomo Hutahaean, Rahmat S.H. Sinaga, Putri C. Situmorang   +3 more
doaj  

Effective description of bistability and irreversibility in apoptosis [PDF]

arXiv, 2021
Apoptosis is a mechanism of programmed cell death in which cells engage in a controlled demolition and prepare to be digested without damaging their environment. In normal conditions apoptosis is repressed, until it is irreversibly induced by an appropriate signal.
arxiv  

Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum

International Journal of Molecular Sciences, 2018
Caspase-3, onto which there is a convergence of the intrinsic and extrinsic apoptotic pathways, is the main executioner of apoptosis. We here review the current literature on the intervention of the protease in the execution of naturally occurring ...
L. Lossi, C. Castagna, A. Merighi
semanticscholar   +1 more source

Apoptotic gene expression in neuropathic pain [PDF]

, 2008
Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system and is associated with several clinical symptoms ...
Annalucia Migliozzi, Carlo Fuccio, Catia Giordano, Dario Siniscalco, Francesco Rossi, Livio Luongo, Sabatino Maione   +6 more
core   +2 more sources

Screening for Caspase-3 Inhibitors: A New Class of Potent Small-Molecule Inhibitors of Caspase-3 [PDF]

SLAS Discovery, 2006
From the authors' 650,000 compound collection, they have selected approximately 15,000 potential small-molecule protease inhibitors, which were subjected to high-throughput screening against caspase-3. The screening yielded a series of hits that belong to 11 different scaffolds.
Sergei Malarchuk, Dmitry V. Kravchenko, Alexandre V. Ivachtchenko, Alexey P. Ilyin, Volodymyr M. Kysil, Alexander Viktorovich Khvat, Elena Dubrovskaya, Ilya Okun, Larry A. Sklar, Eric R. Prossnitz, Sergey E. Tkachenko   +10 more
openaire   +2 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source