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TBK1 and Caspase-8 suppress necroptosis but activate NLRP3 inflammasome activation during CXCL4 and TLR8 costimulation. [PDF]

Cell Death Discov
Cui Y, Zhang Y, Yang C.
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From procaspase‐8 to caspase‐8: Revisiting structural functions of caspase‐8

Journal of Cellular Physiology, 2010
AbstractCaspase‐8 is well‐characterized to initiate an apoptotic pathway triggered by the external stimuli. The proximity‐driven model recently has been proposed to interpret the activation mechanism of caspase‐8 in so‐far unprecedent detail, in which dimerization, autocleavage, and inhibitor of caspase‐8 are indispensable. Intriguingly, death effector
Yang, Zhao, Xin, Sui, Hong, Ren
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Caspase-8 for Outer Harmony

Science Signaling, 2009
Ablation of caspase-8 in keratinocytes activates proliferative and inflammatory responses in the epidermis.
Sollberger, Gabriel, Beer, Hans-Dietmar
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Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade

Blood, 2002
Caspase-8 (Fas-associating protein with death domain–like interleukin-1β– converting enzyme [FLICE]/MACH/Mch5) belongs to a family of cysteine proteases presumed to be the apex of the apoptotic signaling pathways. We recently reported the presence of a novel isoform of caspase-8, named caspase-8L, generated by the alternative splicing of human caspase ...
Daisuke, Himeji, Takahiko, Horiuchi, Hiroshi, Tsukamoto, Kenshi, Hayashi, Takeshi, Watanabe, Mine, Harada   +5 more
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Caspase-8: The double-edged sword

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020
Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggering death receptor-mediated apoptosis, Caspase-8 has also been implicated in the onsets of anoikis, autophagy and ...
Ranadip, Mandal, Joan Compte, Barrón, Izabela, Kostova, Sven, Becker, Klaus, Strebhardt   +4 more
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Non-apoptotic functions of caspase-8

Biochemical Pharmacology, 2008
Caspases are a family of aspartate-specific cysteine proteases that have been well characterized for their function in apoptosis signaling. Caspase-8 is implicated as an initiator caspase in death receptor-induced signaling to apoptosis and has been studied most extensively for its role in CD95-induced cell death.
Jonathan, Maelfait, Rudi, Beyaert
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Anti-inflammatory Functions of Caspase-8

2010
Explorations of the functions of receptors of the TNF/NGF family have led to the discovery of various signaling proteins, many of which were later found to mediate effects of other inducers as well. We now have quite detailed knowledge of the mechanisms and molecular complexes by which some of the signaling proteins mediate these additional effects ...
Akhil, Rajput, Tae-Bong, Kang, Konstantin, Bogdanov, Jin-Chul, Kim, Tehila, Ben-Moshe, Andrew, Kovalenko, David, Wallach   +6 more
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Caspase‐8 Gene Expression in Neuroblastoma

Annals of the New York Academy of Sciences, 2004
Abstract: Neuroblastoma (NB) is a solid tumor of infancy that presents a high rate of spontaneous regression, a phenomenon that likely reflects the activation of an apoptotic/differentiation program. Indeed, the level of expression of molecules involved in the regulation of apoptosis, such as p73 or survivin, is a prognostic factor in NB patients. The
Ida, Casciano, Barbara, Banelli, Michela, Croce, Alessandro, De Ambrosis, Angela, di Vinci, Ilaria, Gelvi, Gabriella, Pagnan, Chiara, Brignole, Giorgio, Allemanni, Silvano, Ferrini, Mirco, Ponzoni, Massimo, Romani   +11 more
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Ripoptosome Analysis by Caspase-8 Coimmunoprecipitation

Cold Spring Harbor Protocols, 2016
The biochemical signaling of cell death pathways is executed at a number of different intracellular and/or membrane-bound high-molecular mass complexes. It is crucial to be able to detect the formation, differences in assembly, and differential composition of such complexes to understand their contribution to the execution phase of apoptotic or ...
Maria, Feoktistova, Peter, Geserick, Martin, Leverkus   +2 more
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Caspase-8 in cancer biology and therapy

Cancer Letters, 2009
Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human ...
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