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Interferon-γ induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter
Journal of Pediatric Surgery, 2004The expression of caspase-8, a cysteine protease that is crucial for the apoptotic cascade, is absent in a high percentage of neuroblastomas, the most frequent extracranial solid tumor of infants and children. Resistance of neuroblastomas to death-receptor (eg, tumor necrosis factor alpha (TNF-alpha) receptor)--mediated apoptosis is thought to be ...
Sunghoon, Kim +3 more
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Clinicopathological Significance of Caspase-8 and Caspase-10 Expression in Rectal Cancer
Oncology, 2008<i>Objectives:</i> To investigate the expression of caspase-8 and -10 in rectal adenoma, adenocarcinoma and the corresponding normal mucosa tissue, and to clarify the relationship between their expression and clinicopathological parameters of rectal cancer.
Bing, Xu +11 more
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Changes in Activities of Caspase-8 and Caspase-9 in Human Cervical Malignancy
International Journal of Gynecological Cancer, 2011The apoptotic process of programmed cell death and its dysfunctions in a variety of human diseases, including cervical cancer, has become the focus of extensive scientific research. Caspases are considered key factors in the execution of apoptosis, although there are many aspects of their role to be elucidated.
Maria Themistokli, Ekonomopoulou +4 more
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The Caspase-8 Modulator c-FLIP
Critical Reviews in Immunology, 2005Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors.
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Activation of Caspase-8 and Caspase-9 are Required for PC12 Cells Differentiation
Journal of Immunoassay and Immunochemistry, 2015Nerve growth factor- (NGF) induced potent activation of caspase-8, and caspase-9 in PC12 cells in a time-dependent manner. Peptide inhibition of caspase activity led to a potent reduction in neurite outgrowth in NGF-treated cells. Although NGF treatment resulted in cell-cycle G0/G1 arrest as detected by FACS cell-cycle analysis, caspase inhibitors ...
Makio, Mogi, Ayami, Kondo
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A Crucial Role of Caspase 3 and Caspase 8 in Paclitaxel-Induced Apoptosis
Molecular Cell Biology Research Communications, 1999The anticancer drug paclitaxel is well known as an inhibitor of microtubule depolymerization, resulting in mitosis arrest. We investigated the mechanism underlying antitumor effects of paclitaxel on the lung adenocarcinoma cell line LC-2-AD. Less than 10 microg/ml paclitaxel induced mitosis arrest upon LC-2-AD, followed by apoptosis, but more than 30 ...
H, Oyaizu +5 more
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Quantification of Active Caspase-3 and Active Caspase-8 in Microglia Cells
2013During microglia activation the levels of active caspase-3, caspase-7 and caspase-8 are increased, which leads to the transcription of proinflammatory cytokines and factors. As such, the induction of caspase activity in microglia can be used as a marker for activation.
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
Cell, 2020Rajendra Karki +2 more
exaly
Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
Annual Review of Immunology, 2022Kate Schröder +2 more
exaly