Results 41 to 50 of about 6,015,666 (337)
Frontiers in Genetics, 2022 Postmenopausal osteoporosis (PMOP) is a systemic metabolic bone disease in postmenopausal women. It has been known that long non-coding RNAs (lncRNAs) play a regulatory role in the progression of osteoporosis.
Yongchang Yang +15 more
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The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
Frontiers in Cell and Developmental Biology, 2022 In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and
I. Suárez-Pereira +15 more
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FADD, Caspase-3, and Caspase-8 and Incidence of Coronary Events [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 Objective— To investigate the relationship between 3 markers of apoptosis, that is, FADD (Fas-associated death domain–containing protein), caspase-3, and caspase-8, and incidence of coronary events (CEs) in a population-based cohort study.
Maria Wigren +9 more
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Breaking bad: necroptosis in the pathogenesis of gastrointestinal diseases
Frontiers in Immunology, 2023 A delicate balance between programmed cell death and proliferation of intestinal epithelial cells (IEC) exists in the gut to maintain homeostasis. Homeostatic cell death programs such as anoikis and apoptosis ensure the replacement of dead epithelia ...
Jay V. Patankar +7 more
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Pro-caspase-3 Is a Major Physiologic Target of Caspase-8 [PDF]
Journal of Biological Chemistry, 1998 The apoptotic signal triggered by ligation of members of the death receptor family is promoted by sequential activation of caspase zymogens. We show here that in a purified system, the initiator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km) of 8.7 x 10(5) and 2.8 x 10(5) M-1 s-1, respectively.
Douglas R. Green +13 more
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RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
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Molecules, 2020 Alzheimer’s disease (AD) is the most common type of dementia and usually manifests as diminished episodic memory and cognitive functions. Caspases are crucial mediators of neuronal death in a number of neurodegenerative diseases, and caspase 8 is ...
Syed Sayeed Ahmad +4 more
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Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study
Journal of the Egyptian National Cancer Institute, 2017 Purpose: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been ...
Masoumeh Aghababazadeh +5 more
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Irisin Protects Against Hind Limb Ischemia Reperfusion Injury
Drug Design, Development and Therapy, 2021 Ayşegül Küçük,1,* Yücel Polat,2 Aydan Kılıçarslan,3 Nuran Süngü,3 Hakan Kartal,4 Ali Doğan Dursun,5,* Mustafa Arslan6 1Kutahya Health Sciences University, Medical Faculty, Department of Physiology, Kutahya ...
Küçük A +6 more
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Cell Reports, 2017 Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD.
Sebastian Horn +9 more
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