Results 51 to 60 of about 459,603 (305)

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8 [PDF]

Journal of Biological Chemistry, 1998
The apoptotic signal triggered by ligation of members of the death receptor family is promoted by sequential activation of caspase zymogens. We show here that in a purified system, the initiator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km) of 8.7 x 10(5) and 2.8 x 10(5) M-1 s-1, respectively.
H R, Stennicke, J M, Jürgensmeier, H, Shin, Q, Deveraux, B B, Wolf, X, Yang, Q, Zhou, H M, Ellerby, L M, Ellerby, D, Bredesen, D R, Green, J C, Reed, C J, Froelich, G S, Salvesen   +13 more
openaire   +2 more sources

The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior

Frontiers in Cell and Developmental Biology, 2022
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and
I. Suárez-Pereira, I. Suárez-Pereira, I. García-Domínguez, L. Bravo, M. Santiago, J. García-Revilla, A. M. Espinosa-Oliva, I. M. Alonso-Bellido, C. López-Martín, E. M. Pérez-Villegas, J. A. Armengol, E. Berrocoso, E. Berrocoso, J. L. Venero, R. M. de Pablos, R. Ruiz   +15 more
doaj   +1 more source

Apoptotic gene expression in neuropathic pain [PDF]

, 2008
Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system and is associated with several clinical symptoms ...
Annalucia Migliozzi, Carlo Fuccio, Catia Giordano, Dario Siniscalco, Francesco Rossi, Livio Luongo, Sabatino Maione   +6 more
core   +2 more sources

Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior

ACR Open Rheumatology, 2022
Objective Fibroblast‐like synoviocytes (FLS) play a pivotal role in rheumatoid arthritis (RA) by contributing to synovial inflammation and progressive joint damage. An imprinted epigenetic state is associated with the FLS aggressive phenotype.
Cecilia Ansalone, Richard I. Ainsworth, Gyrid Nygaard, Rizi Ai, Edward B. Prideaux, Deepa Hammaker, Narayanan B. Perumal, Ken Weichert, Frances Tung, Lalitha Kodandapani, J. Michael Sauder, Elisabeth C. Mertsching, Robert J. Benschop, David L. Boyle, Wei Wang, Gary S. Firestein   +15 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death

Neurobiology of Disease, 2003
Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (ΔTau-1) during neuronal cell death.
Chul-Woong Chung, Yeon-Mi Hong, Sungmin Song, Ha-Na Woo, Yun-Hee Choi, Troy Rohn, Yong-Keun Jung   +6 more
doaj   +1 more source

RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development

Frontiers in Immunology, 2023
Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf, Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Nathaniel Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter   +6 more
doaj   +1 more source

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. [PDF]

, 2015
Caspase-8 is an apical component of cell death pathways. Activated caspase-8 can drive classical caspase-dependent apoptosis and actively inhibits cell death mediated by RIPK3-driven necroptosis.
Bryant, Clare E, Monie, Tom P
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study

Journal of the Egyptian National Cancer Institute, 2017
Purpose: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been ...
Masoumeh Aghababazadeh, Najmeh Dorraki, Fahimeh Afzal Javan, Asieh Sadat Fattahi, Masoumeh Gharib, Alireza Pasdar   +5 more
doaj   +1 more source