Results 51 to 60 of about 456,031 (305)

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8 [PDF]

Journal of Biological Chemistry, 1998
The apoptotic signal triggered by ligation of members of the death receptor family is promoted by sequential activation of caspase zymogens. We show here that in a purified system, the initiator caspases-8 and -10 directly process the executioner pro-caspase-3 with activation rates (kcat/Km) of 8.7 x 10(5) and 2.8 x 10(5) M-1 s-1, respectively.
H R, Stennicke, J M, Jürgensmeier, H, Shin, Q, Deveraux, B B, Wolf, X, Yang, Q, Zhou, H M, Ellerby, L M, Ellerby, D, Bredesen, D R, Green, J C, Reed, C J, Froelich, G S, Salvesen   +13 more
openaire   +2 more sources

The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior

Frontiers in Cell and Developmental Biology, 2022
In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and
I. Suárez-Pereira, I. Suárez-Pereira, I. García-Domínguez, L. Bravo, M. Santiago, J. García-Revilla, A. M. Espinosa-Oliva, I. M. Alonso-Bellido, C. López-Martín, E. M. Pérez-Villegas, J. A. Armengol, E. Berrocoso, E. Berrocoso, J. L. Venero, R. M. de Pablos, R. Ruiz   +15 more
doaj   +1 more source

Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells [PDF]

, 2017
BACKGROUND: Caffeic acid has been shown to induce apoptosis in MG63 osteosarcoma cells. Along with the apoptotic induction, caffeic acid was shown to activate caspase-8, -9 and -3.
Hudono, K. F. (Karina), Putri, A. A. (Amelia), Putri, C. A. (Chantika), Sandra, F. (Ferry)   +3 more
core   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Atypical role of proximal caspase-8 in truncated Tau-induced neurite regression and neuronal cell death

Neurobiology of Disease, 2003
Abnormal Tau protein is known to be closely associated with several neurodegenerative diseases. Previously, we showed that Tau was cleaved by caspase-3 to generate the cleavage product lacking the C-terminus (ΔTau-1) during neuronal cell death.
Chul-Woong Chung, Yeon-Mi Hong, Sungmin Song, Ha-Na Woo, Yun-Hee Choi, Troy Rohn, Yong-Keun Jung   +6 more
doaj   +1 more source

RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development

Frontiers in Immunology, 2023
Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf, Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Nathaniel Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter   +6 more
doaj   +1 more source

Apoptotic gene expression in neuropathic pain [PDF]

, 2008
Pain initiated or caused by a primary lesion or dysfunction in the nervous system is defined as neuropathic pain. It results from direct injury to nerves in the peripheral or central nervous system and is associated with several clinical symptoms ...
Annalucia Migliozzi, Carlo Fuccio, Catia Giordano, Dario Siniscalco, Francesco Rossi, Livio Luongo, Sabatino Maione   +6 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Downregulation of Caspase 8 in a group of Iranian breast cancer patients – A pilot study

Journal of the Egyptian National Cancer Institute, 2017
Purpose: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis. As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been ...
Masoumeh Aghababazadeh, Najmeh Dorraki, Fahimeh Afzal Javan, Asieh Sadat Fattahi, Masoumeh Gharib, Alireza Pasdar   +5 more
doaj   +1 more source

Receptor Interacting Protein Kinase Pathways Regulate Innate B Cell Developmental Checkpoints But Not Effector Function in Mice

Frontiers in Immunology, 2021
Mutations in the scaffolding domain of Receptor Interacting Protein kinases (RIP) underlie the recently described human autoimmune syndrome, CRIA, characterized by lymphadenopathy, splenomegaly, and autoantibody production.
Raksha Parthasarathy, Thomas Hägglöf, Jason T. Hadley, Alexandra McLennan, Alexandra McLennan, Aiden Mattke, Elizabeth A. Dudley, Abigail Kumagai, Lily Q. Dong, Elizabeth A. Leadbetter   +9 more
doaj   +1 more source