Results 1 to 10 of about 444,442 (201)

Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis [PDF]

Journal of Translational Medicine
Background Pulmonary fibrosis (PF) is a progressive interstitial lung disease marked by extracellular matrix accumulation and epithelial damage, with limited therapeutic options.
Juan Wang, Bei Qing, Linguo Gu, Hongzuo Chen, Ying Chen, Yaling Tang, Zhenglian Ge, Rui Hu, Yunchang Yuan, Zhenkun Xia   +9 more
doaj   +2 more sources

Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]

Cell Death and Disease, 2022
Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic communication between endothelial, pericyte, glial, and neuronal cells through signaling ...
Crystal Colón Ortiz, Albertine M. Neal, Maria I. Avrutsky, Monica Choi, Jade Smart, Jacqueline Lawson, Carol M. Troy   +6 more
doaj   +2 more sources

Expression of caspase-3, caspase-9, GDF-9 and IGF-1 genes in ovine oocytes cultured with optimum and elevated doses of Amphiregulin, Neuregulin-1 and Tumour necrosis factor-α in-vitro

Indian Journal of Animal Sciences, 2022
The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY, NANDI SUMANTA, GIRISH KUMAR VENKATESH   +2 more
doaj   +3 more sources

Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease [PDF]

Frontiers in Pharmacology, 2021
Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration.
Maria I. Avrutsky, Carol M. Troy, Carol M. Troy, Carol M. Troy   +3 more
doaj   +2 more sources

Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling [PDF]

Cells, 2022
Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis.
Min Chen, Lei Wang, Min Li, Marietta M. Budai, Jin Wang   +4 more
doaj   +2 more sources

Bcl-2, active caspase-9 and inactive caspase-9 levels as markers of apoptosis in the serum and tissue of vitiligo patients

Al-Azhar Assiut Medical Journal, 2017
Background Vitiligo is the most common depigmentation disorder of the skin. It is considered a multifactorial disorder. However, its exact etiology is unknown.
Eman R.M Hofny, Howayda I Hasan, Nahed A Mohamed, Maysaa S Bamatraf, Ayman M.M Mahran   +4 more
doaj   +2 more sources

Binding and Kinetic Analysis of Human Protein Phosphatase PP2A Interactions with Caspase 9 Protein and the Interfering Peptide C9h [PDF]

Pharmaceutics, 2022
The serine/threonine phosphatase PP2A and the cysteine protease Caspase 9 are two proteins involved in physiological and pathological processes, including cancer and apoptosis.
Karim Dorgham, Samuel Murail, Pierre Tuffery, Eric Savier, Jeronimo Bravo, Angelita Rebollo   +5 more
doaj   +2 more sources

Caspase-9 suppresses metastatic behavior of MDA-MB-231 cells in an adaptive organoid model [PDF]

Scientific Reports
Caspase-9, a cysteine-aspartate protease traditionally associated with intrinsic apoptosis, has recently emerged as having non-apoptotic roles, including influencing cell migration—an aspect that has received limited attention in existing studies. In our
Farzaneh Falahi, Shiva Akbari-Birgani, Yousef Mortazavi, Behrooz Johari   +3 more
doaj   +2 more sources

Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting. [PDF]

Clin Cancer Res
Ventin M, Cattaneo G, Arya S, Jia J, Gelmi MC, Sun Y, Maggs L, Ksander BR, Verdijk RM, Boland GM, Jenkins RW, Haq R, Jager MJ, Wang X, Ryeom S, Ferrone CR.   +15 more
europepmc   +3 more sources

HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro. [PDF]

ACS Chem Biol, 2023
Wang B, Moon SP, Cutolo G, Javed A, Ahn BS, Ryu AH, Pratt MR.   +6 more
europepmc   +3 more sources