Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease. [PDF]
Front Pharmacol, 2021 Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration.
Avrutsky MI, Troy CM.
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Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells. [PDF]
PLoS ONE, 2016 Human periodontal ligament (PDL) cells underwent apoptosis after mechanical stretch loading. However, the exact signalling pathway remains unknown.
Yaqin Wu +4 more
doaj +2 more sources
Caspase-9 swings both ways in the apoptosome
Molecular & Cellular Oncology, 2017 For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
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Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury. [PDF]
Curr Neuropharmacol, 2023 Traumatic brain injury (TBI) is one of the significant causes of death and morbidity, and it is hence a focus of translational research. Apoptosis plays an essential part in the pathophysiology of TBI, and its inhibition may help overcome TBI's negative ...
Unnisa A, Greig NH, Kamal MA.
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Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. [PDF]
ACS Chem Biol, 2021 Caspases are a family of enzymes that regulate biological processes such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome c release from the ...
Araya LE, Soni IV, Hardy JA, Julien O.
europepmc +2 more sources
Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling. [PDF]
Cells, 2022 Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis.
Chen M, Wang L, Li M, Budai MM, Wang J.
europepmc +2 more sources
CASPASE 9 GENE EXPRESSION AND CASPASE 9 PROTEIN IN CHRONIC MYELOID LEUKEMIA IN IRAQ
The Iraqi Journal of Agricultural science, 2022 The following study was carried out to investigate gene expressions of the CASPASE 9 gene and CASPASE 9 protein with the development of chronic myeloid leukemia (CML) in Iraq.
Abdullah W. K., Maha F. A.
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The therapeutic effect of conditioned medium of human amniotic membrane stem cells on heart failure in rats [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. The conditioned medium of stem cells plays an important role in the treatment of various diseases such as heart damage, but its molecular mechanisms are unknown.
Nahid Aboutaleb +4 more
doaj +1 more source
Indian Journal of Animal Sciences, 2022 The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin growth factor-1 (IGF-1) genes in oocytes cultured in vitro with optimum and elevated doses of amphiregulin (50 ng and
RAMESH HONDARAVALLI SOMASHETTY +2 more
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Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion. [PDF]
Nat Commun, 2020 Central nervous system ischemic injury features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here we show that activation of endothelial caspase-9 after hypoxia-ischemia is a critical event in subsequent dysfunction of the ...
Avrutsky MI +13 more
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