CASPASE 9 GENE EXPRESSION AND CASPASE 9 PROTEIN IN CHRONIC MYELOID LEUKEMIA IN IRAQ
The Iraqi Journal of Agricultural science, 2022 The following study was carried out to investigate gene expressions of the CASPASE 9 gene and CASPASE 9 protein with the development of chronic myeloid leukemia (CML) in Iraq.
Abdullah W. K., Maha F. A.
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Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis [PDF]
Journal of Translational MedicineBackground Pulmonary fibrosis (PF) is a progressive interstitial lung disease marked by extracellular matrix accumulation and epithelial damage, with limited therapeutic options.
Juan Wang +9 more
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Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]
Cell Death and Disease, 2022 Retinal neurovascular injuries are a leading cause of vision loss in young adults presenting unmet therapeutic needs. Neurovascular injuries damage homeostatic communication between endothelial, pericyte, glial, and neuronal cells through signaling ...
Crystal Colón Ortiz +6 more
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Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease [PDF]
Frontiers in Pharmacology, 2021 Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic apoptosis, regulates physiological cell death and pathological tissue degeneration.
Maria I. Avrutsky +3 more
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Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling [PDF]
Cells, 2022 Mitochondrial disruption leads to the release of cytochrome c to activate caspase-9 and the downstream caspase cascade for the execution of apoptosis.
Min Chen +4 more
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Quantification of Immunostained Caspase-9 in Retinal Tissue. [PDF]
J Vis Exp, 2022 The family of caspases is known to mediate many cellular pathways beyond cell death, including cell differentiation, axonal pathfinding, and proliferation. Since the identification of the family of cell death proteases, there has been a search for tools to identify and expand the function of specific family members in development, health, and disease ...
Colón Ortiz CK +7 more
europepmc +3 more sources
Oncogene-dependent apoptosis is mediated by caspase-9 [PDF]
Proceedings of the National Academy of Sciences, 1998 Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of ...
Fearnhead, H. O. +6 more
core +4 more sources
Caspase-9 suppresses metastatic behavior of MDA-MB-231 cells in an adaptive organoid model [PDF]
Scientific ReportsCaspase-9, a cysteine-aspartate protease traditionally associated with intrinsic apoptosis, has recently emerged as having non-apoptotic roles, including influencing cell migration—an aspect that has received limited attention in existing studies. In our
Farzaneh Falahi +3 more
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Correction: Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline [PDF]
Cell Death and Disease, 2022 Crystal Colón Ortiz +6 more
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Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
Neurobiology of Disease, 2002 Accumulating evidence supports a role for the activation of proteolytic enzymes, caspases, in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so through a mitochondrial pathway employing caspase-9 or through an alternative ...
Troy T. Rohn +5 more
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