Results 11 to 20 of about 274,382 (304)
Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
Neurobiology of Disease, 2002 Accumulating evidence supports a role for the activation of proteolytic enzymes, caspases, in the Alzheimer's disease (AD) brain. Neurons committed to apoptosis may do so through a mitochondrial pathway employing caspase-9 or through an alternative ...
Troy T. Rohn +5 more
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Caspase-9 swings both ways in the apoptosome [PDF]
Molecular & Cellular Oncology, 2017 For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through ...
Chu-Chiao Wu, Shawn B. Bratton
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Characterization of a Novel Proapoptotic Caspase-2- and Caspase-9-binding Protein [PDF]
Journal of Biological Chemistry, 2001 Caspases play important roles in regulating apoptotic signaling pathways. Here we report the cloning, by the yeast two hybrid system with dominant negative caspase-2 as "bait," of a proapoptotic molecule named proapoptotic caspase adaptor protein (PACAP), encoded by a 372-base pair open reading frame. Binding of this novel protein to caspase-2 (casp-2)
Emanuela Bonfoco +3 more
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Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients. [PDF]
Clin Psychopharmacol Neurosci, 2023 Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients and healthy samples.RNA was isolated from the peripheral blood of 39 schizophrenia patients' and healthy ...
Dirican E +3 more
europepmc +4 more sources
Quantification of Immunostained Caspase-9 in Retinal Tissue. [PDF]
J Vis Exp, 2022 The family of caspases is known to mediate many cellular pathways beyond cell death, including cell differentiation, axonal pathfinding, and proliferation. Since the identification of the family of cell death proteases, there has been a search for tools to identify and expand the function of specific family members in development, health, and disease ...
Colón Ortiz CK +7 more
europepmc +3 more sources
Mechanism of XIAP-Mediated Inhibition of Caspase-9 [PDF]
Molecular Cell, 2003 The inhibitor of apoptosis (IAP) proteins potently inhibit the catalytic activity of caspases. While profound insight into the inhibition of the effector caspases has been gained in recent years, the mechanism of how the initiator caspase-9 is regulated by IAPs remains enigmatic.
Eric N. Shiozaki +8 more
openalex +6 more sources
Diagnostics, 2021 Ovarian cancer remains a major diagnostic and therapeutic problem in modern gynecological oncology. For this reason, research which focuses on the search for new diagnostic markers and the assessment of their possible usefulness in clinical practice is ...
Aleksandra Mielczarek-Palacz +2 more
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Proteolytic Processing of the Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9 [PDF]
Journal of Biological Chemistry, 2013 Maturation of the single-chain caspase-9 zymogen through autoproteolytic processing is mediated by the Apaf-1 apoptosome at the onset of apoptosis. Processed caspase-9 and the apoptosome form a holoenzyme with robust proteolytic activity that is 2-3 orders of magnitude higher than that of free processed caspase-9.
Di Wu +4 more
openaire +2 more sources
The Apoptosome Activates Caspase-9 by Dimerization [PDF]
Molecular Cell, 2006 The apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The mechanism has been debated, and two contrasting hypotheses have been suggested. One of these postulates an allosteric activation of monomeric caspase-9; the other postulates a dimer-driven assembly at the
Cristina Pop +3 more
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GENETIC POLYMORHISM OF CASPASE 8 AND 9 IN IRAQ
The Iraqi Journal of Agricultural science, 2022 This study examined the potential association between polymorphisms of Caspase 9 −293del (rs4645982) and Caspase8−652 6N ins / del (rs3834129) and the danger of acute and chronic myeloid leukaemia in Iraqi population.
Duaa Abdullah , Reema M. Aloubaidy
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