Results 31 to 40 of about 274,382 (304)

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis [PDF]

BMC Cell Biology, 2013
AbstractBackgroundApoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochromecrelease is well described; however the distinct roles of caspases-9, -3 and -7 during this process are not completely defined.ResultsHere we ...
Lawrence H. Boise, Matthew Brentnall, Matthew Brentnall, Luis Rodriguez-Menocal, Enrique Cepero, Rebeka Ladron De Guevara   +5 more
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Altered of apoptotic markers of both extrinsic and intrinsic pathways induced by hepatitis C virus infection in peripheral blood mononuclear cells

Virology Journal, 2012
Background Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across the world. To understand the role of apoptotic pathways in hepatitis C virus (HCV) infection, we studied the mRNA and protein expression patterns of ...
Albertoni Guilherme, Arnoni Carine Prisco, Latini Flávia Roche Moreira, Andrade Sheila Siqueira, Araújo Patrícia Regina Barboza, Rodrigues Flaviane Kesia, Rozenchan Patrícia Bortman, Mendes-Correa Maria Cássia, Leite Olavo Henrique Munhoz, Schor Nestor, Girão Manoel João Castelo Batista, Barreto José   +11 more
doaj   +1 more source

Caspase 9 Promoter Polymorphisms (-1263G>A, -905T>G, -712C>T) in Coronary Artery Disease [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Apoptosis has been involved in a number of pathological conditions including Coronary Artery Disease (CAD). Caspases are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways.
KISHORE KUMAR GUNDAPANENI, NIVAS SHYAMALA, KAUSHIK PURANAM, RAJESH KUMAR GALIMUDI, KEERTHI KUPSAL, KRISHNA REDDY NALLAMALA, SUREKHA RANI HANUMANTH   +6 more
doaj   +1 more source

Caspase-9 cleavage, do you need it? [PDF]

Biochemical Journal, 2007
Caspase-9, which is activated by association with the Apaf-1 (apoptotic protease-activating factor-1) apoptosome complex, cleaves and activates the downstream effector caspases-3 and -7, thereby executing the caspase-cascade and cell-death programme. Although caspase-9 does not need to be cleaved to be active, apoptotic cell death is always accompanied
Twiddy, Davina, Cain, Kelvin
openaire   +3 more sources

Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation

مجله دانشگاه علوم پزشکی بیرجند, 2023
Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are ...
Sina Nikbin, Armin Derakhshideh, Mohammad Ali Azarbayjani, Nasrin Hosseini   +3 more
doaj  

Apoptotic Volume Decrease (AVD) Is Independent of Mitochondrial Dysfunction and Initiator Caspase Activation

Cells, 2012
Persistent cell shrinkage is a major hallmark of apoptotic cell death. The early-phase shrinkage, which starts within 30−120 min after apoptotic stimulation and is called apoptotic volume decrease (AVD), is known to be accomplished by activation of K ...
Takeshi Tsubata, Emi Maeno, Yasunobu Okada   +2 more
doaj   +1 more source

Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. [PDF]

PLoS Biology, 2005
Caspases are responsible for the execution of programmed cell death (apoptosis) and must undergo proteolytic activation, in response to apoptotic stimuli, to function.
Yang Chao, Eric N Shiozaki, Srinivasa M Srinivasula, Daniel J Rigotti, Robert Fairman, Yigong Shi   +5 more
doaj   +1 more source

Regulation of the Apaf-1–caspase-9 apoptosome [PDF]

Journal of Cell Science, 2010
Apoptosis is probably not the only form of cell death, but it is currently the only form for which the proteins that constitute the death pathway have been characterized at the structural, biochemical and genetic levels in great detail.
Guy S. Salvesen, Shawn B. Bratton
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The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125 [PDF]

Journal of Biological Chemistry, 2008
Caspase-9 plays a critical role in the initiation of apoptosis by the mitochondrial pathway. Activation of caspase-9 is inhibited by phosphorylation at Thr(125) by ERK1/2 MAPKs in response to growth factors. Here, we show that phosphorylation of this site is specific for these classical MAPKs and is not strongly induced when JNK and p38alpha/beta MAPKs
Martin, Morag C., Allan, Lindsey A., Mancini, Erika J., Clarke, Paul R.   +3 more
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Mechanism of zinc‐mediated inhibition of caspase‐9 [PDF]

Protein Science, 2012
AbstractZinc‐mediated inhibition is implicated in global caspase regulation, with relief of zinc‐mediated inhibition central to both small‐molecule and natively induced caspase activation. As an initiator, caspase‐9 regulates the upstream stages of the apoptotic caspase cascade, making it a critical control point.
Jeanne A. Hardy, Kristen L. Huber
openaire   +3 more sources