Results 261 to 270 of about 231,701 (306)
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The IAP Proteins: Caspase Inhibitors and Beyond
Science's STKE, 2000Apoptosis, or programmed cell death, occurs as an outcome of signals that direct cells to perish. Whether initiated by specifically activated receptors or induced through viral infection, apoptosis is an important means by which organisms maintain health and homeostasis.
B W, Richter, C S, Duckett
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Natural cellular inhibitors of caspases
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003The crucial role of cell death in many diseases is obvious and has spurred intense research to understand the regulation of apoptotic pathways. Caspase activation is central to many of the apoptotic pathways. In recent years, the study of the regulation of caspase activation and activity in various cell lines and in diseases has revealed highly complex
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NO-releasing NSAIDs are caspase inhibitors
Trends in Immunology, 2001Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independent effects.
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Blood, 2002
Caspase-8 (Fas-associating protein with death domain–like interleukin-1β– converting enzyme [FLICE]/MACH/Mch5) belongs to a family of cysteine proteases presumed to be the apex of the apoptotic signaling pathways. We recently reported the presence of a novel isoform of caspase-8, named caspase-8L, generated by the alternative splicing of human caspase ...
Daisuke, Himeji +5 more
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Caspase-8 (Fas-associating protein with death domain–like interleukin-1β– converting enzyme [FLICE]/MACH/Mch5) belongs to a family of cysteine proteases presumed to be the apex of the apoptotic signaling pathways. We recently reported the presence of a novel isoform of caspase-8, named caspase-8L, generated by the alternative splicing of human caspase ...
Daisuke, Himeji +5 more
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Caspase inhibitors in prevention of apoptosis
Herz, 1999Apoptosis, a morphological distinct form of programmed cell death, is a crucial process during development, the maintenance of cell homeostasis and the regulation of the immune system. A variety of diseases have been found to correlate with physiological apoptosis including cancer, autoimmune disease, viral infection and degenerative disorders ...
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The design and synthesis of sulfonamides as caspase-1 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
William G, Harter +9 more
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Caspase Inhibitors: A Pharmaceutical Industry Perspective
Current Topics in Medicinal Chemistry, 2005Caspase inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death, or apoptosis. Publications detailing programs in the pharmaceutical industry have been more frequent in recent years, ranging from SAR studies to clinically relevant animal models of disease.
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The emerging role of caspase inhibitors in gastrointestinal cancers
Journal of Gastroenterology, 2002Apoptosis is an important process in a wide variety of biological systems, and dysregulation of apoptosis is implicated in many human diseases, including malignancy. In fact, cancer cells demonstrate resistance to a variety of apoptotic stimuli, so that an understanding of the inhibitory mechanisms of apoptosis is particularly important.
Katsuya, Shiraki +2 more
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Characterisation of viral caspase inhibitors
2023Submission note: A thesis submitted in partial fulfilment of the degree of Masters of Science to the Department of Biochemistry, Latrobe Institute of Molecular Science, Faculty of Science, Technology and Engineering, La Trobe University, Bundoora.Apoptosis is a process used to remove cells that are old, damaged and potentially dangerous. Infection of a
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Irreversible Caspase Inhibitors: Tools for Studying Apoptosis
Methods, 1999Irreversible inhibitors of caspase proteases are often used in studies of apoptosis. However, vigorous interpretation of data generated with irreversible inhibitors requires quantitative analysis of their effects on enzyme kinetics. A simple method for the quantitative analysis of affinity irreversible inhibitors is introduced.
J C, Wu, L C, Fritz
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