Results 271 to 280 of about 231,701 (306)

Nicotinyl aspartyl ketones as inhibitors of caspase-3

Bioorganic & Medicinal Chemistry Letters, 2003
Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact in the treatment of several degenerative diseases. Since P(1) aspartic acid is a required element of recognition for this enzyme, a library of capped aspartyl aldehydes was synthesized using solid-phase chemistry.
Elise, Isabel, W Cameron, Black, Christopher I, Bayly, Erich L, Grimm, Marc K, Janes, Daniel J, McKay, Donald W, Nicholson, Dita M, Rasper, Johanne, Renaud, Sophie, Roy, John, Tam, Nancy A, Thornberry, John P, Vaillancourt, Steven, Xanthoudakis, Robert, Zamboni   +14 more
openaire   +2 more sources

Novel caspase inhibitors

2018
The present invention provides novel compounds of formula (I) that are potent and selective non-covalent caspase inhibitors. These compounds nay be used for the treatment of inflammatory diseases.
Dömling, Alexander Stephan Siegfried, Spanu, Pietro, Ulgheri, Fausta   +2 more
openaire   +3 more sources

Protection of Mature Oligodendrocytes by Inhibitors of Caspases and Calpains

Neurochemical Research, 2003
Mature mouse oligodendrocytes (OLs) are susceptible to death in demyelinating diseases such as multiple sclerosis and in brain injury following neurotrauma, ischemia, or stroke. To understand mechanisms leading to death of mature OLs and develop strategies for protection, we utilized cultures of mature mouse OLs to investigate the role of caspases and ...
Joyce A, Benjamins, Liljana, Nedelkoska, Edwin B, George   +2 more
openaire   +2 more sources

Allosteric Site Inhibitors for Caspases

Science's STKE, 2004
The active sites of proteins with enzymatic activity are not always suitable for drug targeting. Hardy et al. report the application of a method called "Tethering" to identify an allosteric site inhibitor on the executioner caspases, caspase-3. Tethering, a commercial method, uses reversible disulfide bond formation
openaire   +1 more source

Inhibitor of Apoptosis Proteins and Caspases

2007
Inhibitors of apoptosis proteins (IAPs) were first identified as insect viral proteins that block host cell apoptosis. Cellular homologs bearing the characteristic baculoviral IAP repeat (BIR) domain have now been found in all metazoans and have more diverse functions than their name suggests.
Jai Y. Yu, John Silke, Paul G. Ekert
openaire   +1 more source

Small-molecule caspase inhibitors

Russian Chemical Reviews, 2010
The review considers low-molecular weight inhibitors of caspases, cysteine proteases being key contributors to apoptosis (programmed cell death). The inhibitors with aspartic acid residues or various heterocyclic systems (both synthetic and natural) are covered. Their possible mechanisms of action are discussed.
openaire   +1 more source

Caspase Inhibitors and Myocardial Apoptosis

International Anesthesiology Clinics, 2005
Yunping, Li, Robert, Cohen
openaire   +2 more sources

Caspase Inhibitor

2020
openaire   +1 more source

Extracellular vesicles encapsulated with caspase-1 inhibitor ameliorate experimental autoimmune myasthenia gravis through targeting macrophages

Journal of Controlled Release, 2023
exaly  

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

Archives of Biochemistry and Biophysics, 1998
Kevin K W Wang, Rathna Nath, Ralph A Nixon   +2 more
exaly