Results 51 to 60 of about 231,701 (306)
Antioxidants, 2021 Isoorientin (Iso), a natural bioactive flavonoid, possesses significant anti-tumor and anti-oxidant activities. Benzo[a]pyrene (BaP) is a food processing injurant with carcinogenicity, teratogenicity, and genotoxicity.
Hao Li +5 more
doaj +1 more source
The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma [PDF]
, 2008 We investigated the cytotoxicity and biology of the novel broad-spectrum hydroxamic acid-based histone deacetylase inhibitor (HDACi), PCI-24781. PCI-24781 was studied alone and combined with bortezomib in Hodgkin lymphoma (L428) and non-Hodgkin's ...
Kevin David +9 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells. [PDF]
PLoS ONE, 2015 Generation of new cardiomyocytes is critical for cardiac repair following myocardial injury, but which kind of stimuli is most important for cardiomyocyte regeneration is still unclear.
Ivana Bulatovic +9 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2021 Cadmium is an environmental metal pollutant that has been a focus of research in recent years, which is reported to cause bone disease; however, its skeletal toxicity and the mechanism involved are not yet fully known. Therefore, this study used MC3T3-E1
Ling Ou +8 more
doaj +1 more source
Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. [PDF]
, 2012 The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to ...
Ebermann, L. +37 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors [PDF]
Cell Chemical Biology, 2020 Caspases control regulated cell death (apoptosis), a process that is crucial in the development of multicellular organisms as well as in various diseases. In order to spatiotemporally study apoptosis, we here develop photoactivatable caspase inhibitors.
Suravi, Chakrabarty +1 more
openaire +2 more sources
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor [PDF]
, 2011 Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Tianhui Hu +8 more
core +1 more source
Caspase-8 catalytic activity is required for maximal TLR-induced cytokine production. [PDF]
, 2016 (A-F) Indicated BMDMs were pretreated with the pan-caspase inhibitor zVAD-fmk (A-C), QVD-oph (D) or IETD-fmk (F) for 1hr prior to 6 hr stimulation with LPS (100 ng/mL).
Melanie Santos-Marrero (3217635) +16 more
core +1 more source