Results 31 to 40 of about 231,701 (306)
PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells [PDF]
, 2012 We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis ...
Dittmann, Kai +37 more
core +1 more source
Caspase inhibitors: viral, cellular and chemical [PDF]
Cell Death & Differentiation, 2006 Caspases, key mediators of apoptosis, are a structurally related family of cysteine proteases that cleave their substrates at aspartic acid residues either to cause cell death or to activate cytokines as part of an immune response. They can be controlled upstream by the regulation of signals that lead to zymogen activation, or downstream by inhibitors ...
Callus, B. A., Vaux, D. L.
openaire +2 more sources
Caspase Inhibitors for the Treatment of Hepatitis C [PDF]
Clinics in Liver Disease, 2009 Decreasing hepatocyte injury and death is an attractive therapeutic target in chronic hepatitis C and other liver diseases. Apoptotic cell death is a critical mechanism responsible for liver injury in hepatitis C, and contributes to hepatic fibrogenesis.
Howard C, Masuoka +2 more
openaire +2 more sources
IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells [PDF]
, 2006 Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood.
Manu Sharma +23 more
core +1 more source
The E. coli effector protein NleF is a caspase inhibitor. [PDF]
PLoS ONE, 2013 Enterohemorrhagic and enteropathogenic E. coli (EHEC and EPEC) can cause severe and potentially life-threatening infections. Their pathogenicity is mediated by at least 40 effector proteins which they inject into their host cells by a type-III secretion ...
Sonja Blasche +12 more
doaj +1 more source
Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells
Indonesian Biomedical Journal, 2017 BACKGROUND: Caffeic acid has been shown to induce apoptosis in MG63 osteosarcoma cells. Along with the apoptotic induction, caffeic acid was shown to activate caspase-8, -9 and -3.
Ferry Sandra +3 more
doaj +1 more source
Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes [PDF]
, 2013 Objective: Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents.
Mayer, Bettina A. +10 more
core +1 more source
Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling
Journal of Tropical Life Science, 2020 Caspase-3 is a biochemical marker for cell apoptosis. Several studies focused on exploring caspase inhibitor potential in natural compounds. Hence, in this study investigated the anthocyanins as anti-apoptotic potential activity through caspase-3 using ...
Dewi Ratih Tirto Sari +3 more
doaj +1 more source
Caspase-9 plays only a minor role in TRAIL-induced apoptosis in NCI-H460 cells. [PDF]
, 2018 (A) Cells were preincubated with caspase-9 inhibitor (z-LEHD-fmk, 50 μM) for 1 h, followed by stimulation with serial dilutions of Db-scTRAIL for 24 h. Viable cells were stained with crystal violet and absorbance was measured at 550 nm.
Lubna Danish (5434982) +4 more
core +1 more source
Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts
Journal of Pharmacological Sciences, 2017 Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome.
Kazuhiro Tamura +6 more
doaj +1 more source