A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells. [PDF]
PLoS ONE, 2016 B-cell superantigens (Sags) bind to conserved sites of the VH or VL regions of immunoglobulin molecules outside their complementarity-determining regions causing the apoptosis of normal cognate B cells.
Daniela Lorenzo +5 more
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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. [PDF]
PLoS ONE, 2012 Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases.
Christopher E Heise +20 more
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Inhibition of distant caspase homologues by natural caspase inhibitors [PDF]
Biochemical Journal, 2001 Caspases play an important role in the ability of animal cells to kill themselves by apoptosis. Caspase activity is regulated in vivo by members of three distinct protease inhibitor families, two of which, baculovirus p35 and members of the inhibitor of apoptosis (IAP) family, are thought to be caspase specific.
Snipas, Scott J. +6 more
openaire +3 more sources
Caspase-1 activation during Eh-macrophage contact degrades cullin-1/5. [PDF]
, 2021 (A, B) THP-1 derived macrophages were pre-incubated with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio) for 10 min.
Kris Chadee (249039) +4 more
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Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J +11 more
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Inhibitors of Caspase-1, Caspase-3, Caspase-6 and Caspase-8 block silica-induced pyroptosis. [PDF]
, 2022 Related to Fig 4. a, Images and cell viability of WT, Nlrp3-/-, Caspase-1-/-, Gsdmd-/-, Gsdme-/- and Gsdmd-/-Gsdme-/- BMDMs pretreated with the indicated caspase inhibitors and stimulated with silica. Arrowheads indicate pyroptotic cells.
Yujie Zou (408340) +12 more
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Septins promote caspase activity and coordinate mitochondrial apoptosis [PDF]
, 2023 Apoptosis is a form of regulated cell death essential for tissue homeostasis and embryonic development. Apoptosis also plays a key role during bacterial infection, yet some intracellular bacterial pathogens (such as Shigella flexneri, whose ...
Hoan Van Ngo +6 more
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Journal of Pharmacological Sciences, 2004 Dracorhodin perchlorate inhibited proliferation of several tumor cell lines. The drug induced oligonucleosomal fragmentation of DNA in HeLa cells and increased caspase-3, -8, -9 activities followed by the degradation of caspase-3 substrates, inhibitor of
Mingyu Xia +6 more
doaj +1 more source
Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]
, 2012 For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087) +20 more
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Caspase-8 is not activated by caspase-3. [PDF]
, 2017 (A) Microscopic images of cells expressing FRET-Bid in the absence or presence of Ac-DEVD-CHO (caspase-3 inhibitor, 20 μM) in Huh-7 and HepG2 cells.
Liping Wu (578606) +6 more
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