Results 11 to 20 of about 231,701 (306)
Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2 [PDF]
EMBO reports, 2017 Caspases are key enzymes responsible for mediating apoptotic cell death. Across species, caspase-2 is the most conserved caspase and stands out due to unique features. Apart from cell death, caspase-2 also regulates autophagy, genomic stability and ageing. Caspase-2 requires dimerization for its activation which is primarily accomplished by recruitment
Gergely Imre +8 more
openaire +6 more sources
Caspase inhibitor attenuates the shape changes in the alveolar ridge following tooth extraction: A pilot study in rats. [PDF]
J Periodontal Res, 2021 Objective The aim of the study was to determine whether the inhibition of apoptosis via pan-caspase inhibitors can attenuate the changes in the alveolar ridge upon tooth extraction.
Schwarze UY, Strauss FJ, Gruber R.
europepmc +3 more sources
Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3 [PDF]
Journal of Biological Chemistry, 2013 Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively. Interestingly, caspase-1 cleaves far fewer cellular substrates than caspase-3 and also shows strong positive cooperativity ...
Datta, Debajyoti +3 more
openaire +7 more sources
Caspase-3/-6/-8 are required for Gsdme-dependent pyroptosis. [PDF]
, 2022 a Images and cell viability of WT, Nlrp3-/-, Caspase-1-/- and Gsdmd-/- BMDMs left untreated or stimulated with ATP and silica. Arrowheads indicate pyroptotic cells. The scale bar represents 100 μm.
Yujie Zou (408340) +12 more
core +1 more source
Caspase-1 activation with concomitant degradation of cullin-1/5. [PDF]
, 2021 (A)THP-1 macrophages were incubated with Eh (10:1 ratio) for increasing time (5 to 30 min) and or /with the pan-caspase inhibitor Z-VAD-fmk (100μM) and caspase-1 specific inhibitor Z-YVAD-fmk (100μM) for 1 h followed by stimulation with Eh (10:1 ratio ...
Kris Chadee (249039) +4 more
core +1 more source
Contribution of caspase(s) to the cell cycle regulation at mitotic phase. [PDF]
PLoS ONE, 2011 Caspases have been suggested to contribute to not only apoptosis regulation but also non-apoptotic cellular phenomena. Recently, we have reported the involvement of caspase-7 to the cell cycle progression at mitotic phase by knockdown of caspase-7 using ...
Toshiaki Hashimoto +2 more
doaj +1 more source
Caspase Substrates and Inhibitors [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors.
Marcin, Poreba +3 more
openaire +2 more sources
New and emerging therapies in gout
Rheumatology & Autoimmunity, 2023 Gout is a disease that has been pestering humankind for centuries. Hence, gout therapeutics has always been a field of ongoing research. Beginning from colchicine, which was the first drug to come into use, to the latest inflammasome inhibitors and ...
Reeta James, Binoy J. Paul
doaj +1 more source
Peptides Targeting Caspase Inhibitors [PDF]
Journal of Biological Chemistry, 2003 Here we report on the identification of peptides targeting the X-inhibitor of apoptosis protein (XIAP). XIAP functions as a caspase inhibitor and is a member of the inhibitors of apoptosis (IAP) family of proteins. IAPs are often overexpressed in cancers and leukemias and are associated with an unfavorable clinical prognosis.
Tamm, Ingo +9 more
openaire +4 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 ...
Loghman Firoozpour +10 more
doaj +1 more source