Results 1 to 10 of about 216,445 (164)

Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy [PDF]

Cells
Fuchs endothelial corneal dystrophy (FECD) is a progressive disorder characterized by endothelial cell loss and excessive extracellular matrix (ECM) accumulation leading to corneal dysfunction. Emricasan, a pan-caspase inhibitor, was investigated for its
Sohya Fujimoto, Mako Endo, Shigehito Tonomura, Fuuga Tsuji, Hirotaka Haraguchi, Kanna Hasegawa, Taisuke Numao, Ayaka Izumi, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Yuki Oyama, Masahito Ikawa, Albert S. Jun, Noriko Koizumi, Naoki Okumura   +15 more
doaj   +2 more sources

Detection of Caspase Activation In Situ by Fluorochrome-Labeled Caspase Inhibitors [PDF]

BioTechniques, 2001
Apoptosis is dependent on the activation of a group of proteolytic enzymes called caspases. Caspase activation can be detected by immunoblotting using caspase-specific antibodies or by caspase activity measurement employing pro-fluorescent substrates ...
P.A. Amstad, G. Yu, G.L. Johnson, B.W. Lee, S. Dhawan, D.J. Phelps   +5 more
doaj   +3 more sources

Benincaside A Induces p53-Dependent Transactivation and Fas/CD95-Mediated Apoptosis in HCT 116 Human Colorectal Cancer Cells [PDF]

Current Issues in Molecular Biology
An undescribed seco-kaurane diterpenoid, benincaside A (BA), was isolated from the seeds of Benincasa hispida. The seeds of B. hispida have been traditionally used in folk medicine and previous studies have reported anti-tumor potential in B.
Jai-Sing Yang, Kun-Ching Cheng, Yu-Hsiu Chuang, Ping-Chung Kuo, Tian-Shung Wu   +4 more
doaj   +2 more sources

Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model [PDF]

Frontiers in Neuroscience
Suhrud M Rajguru
exaly   +2 more sources

Caspase Inhibition as a Possible Therapeutic Strategy for Pemphigus Vulgaris: A Systematic Review of Current Evidence

Biology, 2022
Background: Pemphigus vulgaris (PV) is an IgG-mediated autoimmune disease characterised by epithelial cell–cell detachment (acantholysis) resulting in mucocutaneous blistering.
Sanna Huda, Bethany Chau, Chuanqi Chen, Herman Somal, Neiloy Chowdhury, Nicola Cirillo   +5 more
doaj   +1 more source

Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation

Redox Biology, 2021
To determine the roles of nuclear localization of pro-caspase-1 in human aortic endothelial cells (HAECs) activated by proatherogenic lipid lysophosphatidylcholine (LPC), we examined cytosolic and nuclear localization of pro-caspase-1, identified nuclear
Yifan Lu, Gayani Nanayakkara, Yu Sun, Lu Liu, Keman Xu, Charles Drummer, IV, Ying Shao, Fatma Saaoud, Eric T. Choi, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +11 more
doaj   +1 more source

Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling

Acta Pharmaceutica Sinica B, 2021
Inflammatory caspase-11 senses and is activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis that has critical role in defensing against bacterial infection, whereas its excess activation under pathogenic circumstances may cause ...
Jiezhou Ye, Bo Zeng, Meiyan Zhong, Hongchun Li, Lihui Xu, Junxiang Shu, Yaofeng Wang, Fan Yang, Chunsu Zhong, Xunjia Ye, Xianhui He, Dongyun Ouyang   +11 more
doaj   +1 more source

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis

Biology, 2021
Monocyte chemoattractant protein-1-induced protein 1 (MCPIP1) is rapidly produced under proinflammatory stimuli, thereby feeding back to downregulate excessive inflammation.
Fat-Moon Suk, Chi-Ching Chang, Pei-Chi Sun, Wei-Ting Ke, Chia-Chen Chung, Kun-Lin Lee, Tze-Sian Chan, Yu-Chih Liang   +7 more
doaj   +1 more source

Caspase inhibitors [PDF]

Cell Death & Differentiation, 1999
Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
openaire   +2 more sources

The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels

Molecules, 2022
Propyl gallate [3,4,5-trihydroxybenzoic acid propyl ester; PG] exhibits an anti-growth effect in various cells. In this study, the anti-apoptotic effects of various caspase inhibitors were evaluated in PG-treated Calu-6 and A549 lung cancer cells in ...
Woo hyun Park
doaj   +1 more source