Results 81 to 90 of about 231,701 (306)

SB431542, a Selective Inhibitor of the TGF-β Type I Receptor, Enhances Doxorubicin Antitumor Activity via p63 Activation in Mutant p53 Breast Cancer Cells

Frontiers in Bioscience-Landmark
Background: TP53 gene mutations are common in breast cancer and are linked to chemoresistance. p63, a p53 family member, can induce apoptosis independently of p53, representing a potential therapeutic target in TP53-mutant tumors. This
Yu-Ling Kou, Yu-Jie Liu, Tzu-Chi Hsu, Kuan-Yo Wu, Sih-Tong Chen, Jing-Yan Chen, Kuan-Yu Lin, Hsiao-Hsuan Wang, Yi-Ting Cheng, Chia-Chi Chen, Bi-He Cai   +10 more
doaj   +1 more source

Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia

Journal of Translational Medicine, 2023
Background Cyclooxygenase (COX)-2 is a rate-limiting enzyme in the biosynthesis of prostanoids, which is mostly inducible by inflammatory cytokines. The participation of COX-2 in the maturation of megakaryocytes has been reported but barely studied in ...
Xibing Zhuang, Pengcheng Xu, Yang Ou, Xia Shao, Ying Li, Yanna Ma, Shanshan Qin, Fanli Hua, Yanxia Zhan, Lili Ji, Tiankui Qiao, Hao Chen, Yunfeng Cheng   +12 more
doaj   +1 more source

More than cell death: caspases and caspase inhibitors on the move.

Developmental cell, 2004
It is becoming clear that "apoptotic" caspases can effect cellular processes other than cell death. A recent paper in Cell points to a novel role of the Drosophila caspase inhibitor DIAP1 as a determinant of cell migration.
Dotto, G. Paolo., Silke, John Hendry.
openaire   +3 more sources

The inhibitor profiling of the caspase family of proteases using substrate-derived peptide glyoxals. [PDF]

, 2010
A series of substrate-based a-keto-ß-aldehyde (glyoxal) sequences have been synthesised and evaluated as inhibitors of the caspase family of cysteine proteases. A number of potent inhibitor sequences have been identified.
Walker, Brian, Diarmaid J. Murphy, Ciara A. Ryan, Brian Walker, Ryan, Ciara A., S. Lorraine Martin, Murphy, Diarmaid, Martin, Lorraine; id_orcid   +7 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Possible Involvement of Both Endoplasmic Reticulumand Mitochondria-Dependent Pathways in Thapsigargin-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells

Journal of Pharmacological Sciences, 2003
Recently, it has been shown that endoplasmic reticulum (ER) stress causes apoptosis. However, the mechanism of the ER stress-dependent pathway is not fully understood. In human neuroblastoma SH-SY5Y cells, we detected a caspase-12-like protein that has a
Yoshihisa Kitamura, Atsushi Miyamura, Kazuyuki Takata, Masatoshi Inden, Daiju Tsuchiya, Kumi Nakamura, Takashi Taniguchi   +6 more
doaj   +1 more source

NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis. [PDF]

PLoS ONE, 2015
Found in neurons and neuroblastoma cells, Fas-induced apoptosis and accompanied activation of NF-κB signaling were thought to be associated with neurodegenerative diseases. However, the detailed functions of NF-κB activation in Fas killing and the effect
Hai-Jie Yang, Mian Wang, Lei Wang, Bin-Feng Cheng, Xiao-Yu Lin, Zhi-Wei Feng   +5 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Clustering human dental pulp fibroblasts spontaneously activate NLRP3 and AIM2 inflammasomes and induce IL-1β secretion

Regenerative Therapy
Objectives: The objective of the present study was to investigate whether NOD-like receptor family pyrin domain-containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes pathways were involved in an experimental model of fibroblast activation ...
Shafei Zhai, Lihui Zhang, Xue Li, Qi Yu, Changkui Liu   +4 more
doaj   +1 more source

Steady state and (bi-) stability evaluation of simple protease signalling networks [PDF]

, 2007
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper understanding requires a system analysis. Important aspects are the number, location and stability of steady states.
Allgöwer, F., Waldherr, Steffen, Bullinger, Eric, Eissing, T., Scheurich, Peter, Allgöwer, Frank, Allgoewer, Frank, Eissing, Thomas, Waldherr, S., Scheurich, P.   +9 more
core   +1 more source