Results 101 to 110 of about 231,701 (306)

Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA [PDF]

, 2010
Although caspase activation is generally thought to be necessary to induce apoptosis, recent evidence suggests that apoptosis can be activated in the setting of caspase inhibition.
Jun H. Choi, Soochan Bae, Sangita Choudhury, Choi, Jun H., Choudhury, Sangita, Parco M. Siu, Siu, Parco M., Qingen Ke, Koh, Young Y., Kang, Peter M., Ke, Qingen, Bae, Soochan, Young Y. Koh, Peter M. Kang   +13 more
core   +1 more source

Glucose Deprivation‐Driven Concurrent Induction of Apoptosis/Disulfidptosis/Ferroptosis by Tumor Targeting Nanoassemblies in Triple‐Negative Breast Cancer Therapy

Advanced Functional Materials, EarlyView.
Innovative hybrid nanoassemblies installed with ferrocene, D‐α‐tocopherol succinate, and phloretin exploit the metabolic vulnerability of triple‐negative breast cancer under glucose starvation. By blocking glucose uptake, this single nanoplatform simultaneously orchestrates apoptosis, disulfidptosis, and ferroptosis to achieve synergistic and ...
Song Yi Lee, ChaeRim Hwang, Seong Eun Kim, Mrinmoy Karmakar, Seo Jin Jung, Hyeonseok Jang, Hae‐In Kim, Heejung Yang, Junmin Lee, Dae‐Duk Kim, Hyun‐Jong Cho   +10 more
wiley   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells

Journal of Pharmacological Sciences, 2011
The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro, Takashi Kishino, Yu Ohshima, Yasuhiro Yoshioka, Tomoki Kimura, Atsushi Kasai, Sadaaki Maeda   +6 more
doaj   +1 more source

Effects of PDTC and caspase-8 inhibitor on MUTZ-1 cells. [PDF]

, 2014
(A) Effects of PDTC on MUTZ-1 cell hTERT mRNA expression. Detection of hTERT mRNA from MUTZ-1 cells treated with 100 µM PDTC for the indicated times using Quantitative RT-PCR. (B) Effects of PDTC on MUTZ-1 cell caspase-8 protein level.
Wenbin Qian (664489), Weilai Xu (664488), Hongyan Tong (425070), Jie Jin (52722), Yungui Wang (564241)   +4 more
core   +1 more source

Mechanism‐Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis

Advanced Materials, EarlyView.
Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang, Tianbao Zhu, An‐Qi Liu, Jia‐Jia Deng, Ya‐Li Han, Sheng‐Cai Qi, Xue Liu, Tian‐Yi Jiang, Ming‐Rui Zhai, Yu‐Ying He, Xiu‐Juan Li, Hong‐Ting Da, Rui Xu, Xiaomin Li, Jun Gao, Yue‐Hua Liu   +15 more
wiley   +1 more source

TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells

BMC Cancer, 2006
Background Activation of caspase-9 in response to treatment with cytotoxic drugs is inhibited in NSCLC cells, which may contribute to the clinical resistance to chemotherapy shown in this type of tumor. The aim of the present study was to investigate the
Ferreira Carlos G, Hoogeland Bas SJ, Giaccone Giuseppe, Checinska Agnieszka, Rodriguez Jose A, Kruyt Frank AE   +5 more
doaj   +1 more source

The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor [PDF]

I3MT-3 (HMPSNE) has been identified as a selective inhibitor of the supersulfide-producing enzyme 3-MST. In this study, we found that I3MT-3 inhibits inflammatory responses, including the secretion of the pro-inflammatory cytokine interleukin-1β (IL-
Wakana Suzuki, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa, Kohei Otani, Ryuto Komatsu   +5 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Asymmetric Total Synthesis of the Caspase-1 Inhibitor (−)-Berkeleyamide A [PDF]

, 2016
The asymmetric total synthesis of (−)-berkeleyamide A (1), a naturally occurring caspase-1 inhibitor, has been achieved by employing Evans’ syn-aldol reaction of N-acyl-(4R)-benzyl oxazolidin-2-one 3 as the key ...
Mitchell A. Avery (239950), Swapnil J. Kulkarni (2300602), Yakambram Pedduri (2252587), Amar G. Chittiboyina (1378338)   +3 more
core   +1 more source