Results 121 to 130 of about 231,701 (306)

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

Frontiers in Immunology
NLRP3 (NLR family pyrin domain-containing 3) inflammasome is a first line of defense of innate immunity, mediating caspase-1-dependent pyroptosis and cytokine release upon danger signaling.
Ying-qing Gan, Yuan-wen Cai, Xiu-wen Liang, Ling-Zhi Wang, Fu-li Shi, Nuo Sun, Nuo Sun, Nuo Sun, Ya-ping Li, Ya-ping Li, Ya-ping Li, Rong Xu, Bo Hu, Qing-bing Zha, Qing-bing Zha, Xian-hui He, Xian-hui He, Xian-hui He, Tak-sui Wong, Tak-sui Wong, Jin-hua Li, Jin-hua Li, Dong-yun Ouyang   +22 more
doaj   +1 more source

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis [PDF]

, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Contrant, M, Johanna Viiliäinen, Vladimir Benes, Päivi M. Ojala, Voinnet Olivier, Gros, Frédéric, Voinnet, Olivier, Viiliainen, J, Mihaela Zavolan, Benes, Vladimir, Haas Juergen G., Suffert, G, Georg Malterer, Guillaume Suffert, Malterer, G, Frédéric Gros, Gros Frédéric, Ojala, Päivi M, Viiliäinen, Johanna, Suffert, Guillaume, Olivier Voinnet, Hausser Jean, Fender, A, Malterer Georg, Benes, V, Zavolan Mihaela, Ojala Päivi M., Haas, JG, Päivi M Ojala, Hausser, J, Viiliäinen Johanna, Zavolan, Mihaela, Hausser, Jean, Voinnet, O, Suffert Guillaume, Maud Contrant, Pfeffer Sébastien, Haas, Jürgen G., Zavolan, M, Jean Hausser, Tomi Ivacevic, Contrant Maud, Malterer, Georg, Benes Vladimir, Sébastien Pfeffer, Fender Aurélie, Haas, Juergen G, Ivacevic, T, Ojala, PM, Juergen G Haas, Ivacevic, Tomi, Aurélie Fender, Fender, Aurélie, Ojala, Päivi M., Pfeffer, Sébastien, Gros, F, Pfeffer, S, Contrant, Maud, Juergen G. Haas, Ivacevic Tomi, Haas, Juergen G.   +60 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Effect of caspase-8/9 inhibitor on JD induced cell apoptosis. [PDF]

, 2015
A. Apoptosis induced by JD or/with Caspase-8 inhibitor (Z-IETD-FMK) or Caspase-9 inhibitor (Z-LEHD-FMK). A representative result of 3 independent experiments is shown. B. The percentage of FITC-positive cells of 3 independent experiments is shown as Mean
Junwei Wang (239285), Ran Wang (169166), Yongmei Li (227480), Ying Liu (18461), Guiqin Hou (759169), Saiqi Wang (759166), Hongge Shi (759167), Hongmin Liu (759171), Liping Jiang (306239), Yinhui Dou (759168), Cong Wang (107450), Yu Ke (759170)   +11 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor [PDF]

, 2001
Caspases have been implicated in the effector process of apoptosis in several systems including the Fas-Fas ligand pathway. We previously demonstrated that excessive apoptosis of lung epithelial cells and the Fas-Fas ligand pathway were essential in the
Nobuyuki Hara, Michihiro Yoshimi, Takashige Maeyama, Masayuki Kawasaki, Ichiro Inoshima, Naoki Hagimoto, Kazuyoshi Kuwano, Ritsuko Kunitake, Koichiro Yoshida, Tokuji Matsuba   +9 more
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Nature Communications, 2018
Caspase-1, activated by stress in immune cells and in CNS human neurons, may contribute to neuronal degeneration. Here, the authors investigate the therapeutic potential of a Caspase-1 inhibitor in a mouse model of Alzheimer’s disease.
Joseph Flores, Anastasia Noël, Bénédicte Foveau, Jeffrey Lynham, Clotilde Lecrux, Andréa C. LeBlanc   +5 more
doaj   +1 more source

Pan-Caspase Inhibitor zVAD Induces Necroptotic and Autophagic Cell Death in TLR3/4-Stimulated Macrophages. [PDF]

Mol Cells, 2022
Chen YS, Chuang WC, Kung HN, Cheng CY, Huang DY, Sekar P, Lin WW.   +6 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source