Results 111 to 120 of about 231,701 (306)

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Virtual screening and experimental analysis of caspase-7 inhibitors as candidates for extending the lifespan of CHO cells

Electronic Journal of Biotechnology
Background: Chinese hamster ovarian (CHO) cells are widely employed in biotechnology for the production of recombinant proteins. Extending the life span of CHO cells and inhibiting the loss of producing cell population through the inhibition of apoptosis
Sara Kafi, Sajad Najafi, Karim Mahnam, Shirin Farivar, Javad Ranjbari   +4 more
doaj   +1 more source

Soybean antigen protein induces caspase-3/mitochondrion-regulated apoptosis in IPEC-J2 cells

Food and Agricultural Immunology, 2020
β-Conglycinin and glycinin are known to induce various allergic reactions, however, but little is known about the mechanism underlying the development of allergy to soybean antigen proteins.
Chenglu Peng, Zhifeng Sun, Lei Wang, Yingshuang Shu, Mengchu He, Hongyan Ding, Yu Li, Xichun Wang, Shibin Feng, Jinchun Li, Jinjie Wu   +10 more
doaj   +1 more source

Caspase-3 inhibitor reduces p38 phosphorylation induced by hyperosmotic shock. [PDF]

, 2015
Oocytes were incubated with 200 mM sorbitol for 4 h in the presence or absence of caspase-3 inhibitor Z-DEVD.fmk (50 μM), or with 400 mM sorbitol for 1 h. Pools of 20 oocytes were collected and pp38, p38, cytochrome c (CC) and AMPK (loading control) were
José M. López (721041), Nabil Ben Messaoud (721037), Ilina Katzarova (721040)   +2 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival

Cell Transplantation, 2004
One experimental therapy for Parkinson's disease (PD) is the transplantation of embryonic ventral mesencephalic tissue. Unfortunately, up to 95% of grafted neurons die, many via apoptosis.
Deanna M. Marchionini, Timothy J. Collier, Mark R. Pitzer, Caryl E. Sortwell   +3 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7

Cancer Cell International, 2003
Background Styrylpyrone derivative (SPD) is a plant-derived pharmacologically active compound extracted from Goniothalamus sp. Previously, we have reported that SPD inhibited the proliferation of MCF-7 human breast cancer cells by inducing apoptotic cell
Tan Ann, Azimahtol Hawariah, Lee Alvin
doaj   +1 more source

Inhibition of caspase-8 and caspase-9 suppressed the protein level of the cleaved caspase-3. [PDF]

, 2016
Western Blot results after inhibiting either caspase-8 or caspase-9 or both of them. (i, ii) Representative protein bands of Western Blot experiments. (a, b) Mean expression levels of the proteins normalized to GAPDH, from three independent experiments ...
Chun Xu (286394), Fuqiang Zhang (404974), Dan Zhao (285025), Jiabao Zhuang (3394868), Yaqin Wu (275577)   +4 more
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source