Results 131 to 140 of about 231,701 (306)

Effect of caspase inhibitors on hemodynamics and inflammatory factors in ARDS model rats

Scientific Reports
To study the effects of caspase inhibitors on hemodynamics and inflammatory factors in acute respiratory distress syndrome (ARDS) model rats. Sixty healthy male Wistar rats were randomly divided into three groups, namely, the control group, ARDS group ...
Aiming Liu, Fei Tian, Yaqing Zhou, Zunguo Pu   +3 more
doaj   +1 more source

Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

Neoplasia: An International Journal for Oncology Research, 2011
Searching for new strategies to bypass apoptosis resistance, we investigated the potential of the Smac mimetic BV6 in Jurkat leukemia cells deficient in key molecules of the death receptor pathway.
Bram Laukens, Claudia Jennewein, Barbara Schenk, Nele Vanlangenakker, Alexander Schier, Silvia Cristofanon, Kerry Zobel, Kurt Deshayes, Domagoj Vucic, Irmela Jeremias, Mathieu J.M. Bertrand, Peter Vandenabeele, Simone Fulda   +12 more
doaj   +1 more source

Effect of a pan-caspase inhibitor on Protochlamydia-induced apoptosis. [PDF]

, 2013
A) Representative images showing cell death of HEp-2 cells stimulated with bacteria at an MOI of 100 in the presence or absence of a pan-caspase inhibitor (100 µM) at 24 h after incubation. Staurosporine (10 µM); positive control.
Hiroki Nagai (236046), Atsushi Ito (187329), Fumihiko Takeuchi (118220), Tsuyoshi Sekizuka (249989), Chihiro Sugimoto (134113), Junji Matsuo (187334), Kasumi Ishida (281240), Kyoko Hayashida (281242), Tomohiro Yamazaki (281239), Shinji Nakamura (187336), Kaori Takahashi (187346), Yasuhiro Hayashi (187342), Hiroyuki Yamaguchi (187348), Makoto Kuroda (249974), Mitsutaka Yoshida (187344)   +14 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism

Diabetes, Metabolic Syndrome and Obesity
Hong Jiang,1 Mengya Gao,1 Jiaqi Liu,2 Lijuan Yang,2 Lei Liu1 1Department of Nephrology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Physiology, Bengbu Medical University, Bengbu ...
Jiang H, Gao M, Liu J, Yang L, Liu L
doaj  

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Berberine triggers necroptosis of cervical H8 cells by activating receptor-interacting protein kinase 1

Bangladesh Journal of Pharmacology
This study aims to investigate the effect of berberine on necroptosis in cervical H8 cells. CCK-8 assay was used to assess cell proliferation activity. The expression levels of necroptosis key markers Receptor-interacting protein kinase 1 (RIPK1), MLKL,
Mengting Wang, Huixian Chen, Qian Wu, Yan Huang, Yuzhen Zhou   +4 more
doaj   +1 more source

Regulation of Mitochondria-dependent Apoptosis in Non-Small Cell Lung Cancer: Implications for Cancer Therapy [PDF]

, 2007
Summary The work described in this thesis focuses on the characterization of the mechanism(s) underlying the deregulated activation of the intrinsic or mitochondrial apoptotic pathway in non-small cell lung cancer (NSCLC) cells.
Checinska, A.
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source