Results 211 to 220 of about 163,200 (259)

Natural cellular inhibitors of caspases

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003
The crucial role of cell death in many diseases is obvious and has spurred intense research to understand the regulation of apoptotic pathways. Caspase activation is central to many of the apoptotic pathways. In recent years, the study of the regulation of caspase activation and activity in various cell lines and in diseases has revealed highly complex
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NO-releasing NSAIDs are caspase inhibitors

Trends in Immunology, 2001
Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)-dependent and -independent effects.
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Caspase inhibitors in prevention of apoptosis

Herz, 1999
Apoptosis, a morphological distinct form of programmed cell death, is a crucial process during development, the maintenance of cell homeostasis and the regulation of the immune system. A variety of diseases have been found to correlate with physiological apoptosis including cancer, autoimmune disease, viral infection and degenerative disorders ...
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The IAP Proteins: Caspase Inhibitors and Beyond

Science's STKE, 2000
Apoptosis, or programmed cell death, occurs as an outcome of signals that direct cells to perish. Whether initiated by specifically activated receptors or induced through viral infection, apoptosis is an important means by which organisms maintain health and homeostasis.
B W, Richter, C S, Duckett
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Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade

Blood, 2002
Caspase-8 (Fas-associating protein with death domain–like interleukin-1β– converting enzyme [FLICE]/MACH/Mch5) belongs to a family of cysteine proteases presumed to be the apex of the apoptotic signaling pathways. We recently reported the presence of a novel isoform of caspase-8, named caspase-8L, generated by the alternative splicing of human caspase ...
Daisuke, Himeji, Takahiko, Horiuchi, Hiroshi, Tsukamoto, Kenshi, Hayashi, Takeshi, Watanabe, Mine, Harada   +5 more
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Caspase Inhibitors: A Pharmaceutical Industry Perspective

Current Topics in Medicinal Chemistry, 2005
Caspase inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death, or apoptosis. Publications detailing programs in the pharmaceutical industry have been more frequent in recent years, ranging from SAR studies to clinically relevant animal models of disease.
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Caspase Inhibitors and Myocardial Apoptosis

International Anesthesiology Clinics, 2005
Yunping, Li, Robert, Cohen
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Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders

European Journal of Medicinal Chemistry, 2022
Maria Pia Fuggetta, Matthew Groves, Fausta Ulgheri   +2 more
exaly  

Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors

Cell Chemical Biology, 2020
Steven Verhelst
exaly  

Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity

Biochemical and Biophysical Research Communications, 2008
Zhiwei Song
exaly