Results 201 to 210 of about 163,200 (259)

Targeting mitochondria as a potential therapeutic strategy against radioresistance in cancer. [PDF]

Front Oncol
Nazam N, Sadiya S, Khan S, Misra A, Sureka N, Panwar K, Sahani N, Zaheer S.   +7 more
europepmc   +1 more source

A novel prenylflavonoid with efficacy in cancer therapy by targeting ceramide-orchestrated signaling. [PDF]

Front Pharmacol
Du R, Zhang C, Lei H, Gao X, Xiang Q, Zhang Z, Dai Y, Li X, Zhang L, Chen G.   +9 more
europepmc   +1 more source

The Paradoxical Role of Pyroptosis in Gastrointestinal Cancers: From Molecular Mechanisms to Therapeutic Horizons. [PDF]

Biomedicines
Triantafillidis JK.
europepmc   +1 more source

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Caspase inhibitors as neuroprotective agents

Expert Opinion on Emerging Drugs, 2001
Apoptotic neuronal cell death has been demonstrated to occur in the central nervous system (CNS), following both acute injury and during chronic neurodegenerative conditions. Currently, the majority of experimental evidence for a role of caspases in CNS damage has been established following acute neuronal insults, including ischaemic stroke, traumatic ...
J A Erhardt
exaly   +3 more sources

Caspases and caspase inhibitors

Trends in Biochemical Sciences, 1997
Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and ...
P, Villa, S H, Kaufmann, W C, Earnshaw
openaire   +2 more sources

Neuroprotection by caspase inhibitors

Expert Opinion on Investigational Drugs, 1999
In the majority of brain diseases, apoptosis causes or exacerbates neuronal damage. Caspases are the final executioners of the apoptotic cell death programme. This family of proteases is implicated in the pathogenesis of many forms of brain damage, including those induced by ischaemia, inflammation or trauma, as well as those arising in Alzheimer's ...
, Braun, , Tuomanen, , Cleveland
openaire   +2 more sources

Prospects for Caspase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2004
Programmed cell death, or apoptosis, is executed by a series of Cysteine Aspartyl Proteases (Caspases) that form a proteolytic cascade. Each caspase functions either to activate downstream caspases by proteolytic cleavage and/or to proteolytically cleave cellular substrates.
Tom, O'Brien, Dennis, Lee
openaire   +2 more sources

Endogenous Inhibitors of Caspases

Journal of Clinical Immunology, 1999
Caspases are cysteine proteases that are specific for aspastic acid residues. These enzymes have been extensively characterized as integral and highly conserved components of a variety of cell death programs. Cowpox and several insect viruses have evolved mechanisms that counter host cell suicide by encoding proteins that directly inhibit caspases ...
Q L, Deveraux, H R, Stennicke, G S, Salvesen, J C, Reed   +3 more
openaire   +2 more sources