Results 241 to 250 of about 134,771 (282)

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

The homeodomain-interacting protein kinase Hipk promotes apoptosis by stabilizing the active form of Dronc. [PDF]

Cell Death Discov
García-Arias JM, Juárez-Uribe RA, Baena-López LA, Morata G, Sánchez-Herrero E.   +4 more
europepmc   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death. [PDF]

Front Immunol
Molyer B, Ameeriar Y, Angel JB.
europepmc   +1 more source

Pyroptosis in ulcerative colitis: biomarkers and therapeutic targets. [PDF]

J Biomed Sci
Cruz H, Shah P, Wohlgemuth N, Ketchum R, Nassif I, Hu CA.   +5 more
europepmc   +1 more source

Effects of surface-exposed sialic acid and LOS outer core on the ability of native Neisseria meningitidis outer membrane vesicles (nOMVs) to induce cytokine expression and pyroptotic pathways in THP-1-derived macrophages. [PDF]

Sci Rep
Resta SC, Talà A, Baccante A, Saudino G, Petruccelli P, Di Cioccio V, Bucci C, Alifano P.   +7 more
europepmc   +1 more source

Camptothecin in Cancer Therapy: Current Challenges and Emerging Strategies with Nanoemulsions. [PDF]

Pharmaceutics
Pérez-Ortega HU, Córdova-Espíritu RR, Cano-Serrano S, García-González E, Bravo-Sánchez MG, Orozco-Mosqueda MDC, Jiménez-Islas H, Luna-Bárcenas G, Villaseñor-Ortega F.   +8 more
europepmc   +1 more source

Ambiguous Role of p53 in Transcription-Dependent Tumor Cell Death. [PDF]

Int J Mol Sci
Romanova AA, Grigoreva TA, Zenina AD, Smirnaya AD, Margolina KY, Sagaidak A, Tribulovich VG.   +6 more
europepmc   +1 more source

Alisol A Exerts Anti-Proliferative Activity against Human Oral Cancer Cells through Triggering JNK/p38 MAPK-Mediated Apoptotic Cascade. [PDF]

Oncol Res
Chen YT, Kao SH, Chuang CY, Su CW, Yang WE, Tang CH, Yang SF, Lin CW.   +7 more
europepmc   +1 more source