Results 271 to 280 of about 170,565 (294)

Alisol A Exerts Anti-Proliferative Activity against Human Oral Cancer Cells through Triggering JNK/p38 MAPK-Mediated Apoptotic Cascade. [PDF]

Oncol Res
Chen YT, Kao SH, Chuang CY, Su CW, Yang WE, Tang CH, Yang SF, Lin CW.   +7 more
europepmc   +1 more source

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

Apoptotic Caspases-3 and -7 Cleave Extracellular Domains of Membrane-Bound Proteins from MDA-MB-231 Breast Cancer Cells. [PDF]

Int J Mol Sci
Vidak E, Vizovišek M, Kavčič N, Biasizzo M, Fonović M, Turk B.   +5 more
europepmc   +1 more source

Imuno-expressão de Cox-2, Caspase 3, Ki67 e Survivina em tumor venéreo transmissível canino.

, 2015
Sandra Bassani Silva, Haline Feo Ballesteros, Luis Maurício Montoya Flórez, Noeme Sousa Rocha   +3 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Restoring apoptosis in breast cancer via peptide mediated disruption of survivin IAP interaction. [PDF]

Sci Rep
Taghavifar SM, Sabbaghfarshi S, Samadikhah H, Tackallou SH, Ahmadi SF.   +4 more
europepmc   +1 more source

The Contribution Of Metabolism To The Regulation Of Caspase Activity And Cell Death In T Lymphocytes

, 2019
Michael A. Secinaro
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Caspase Domain Duplication During the Evolution of Caspase-16. [PDF]

J Mol Evol
Eckhart L, Sachslehner AP, Steinbinder J, Fischer H.   +3 more
europepmc   +1 more source

Magnesium Structure‐Function Integration Platform for Spatiotemporal Multi‐Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
The schematic illustration of the MHSCG platform for spatiotemporal responsive GRb1 release to induce androgen deprivation therapy (ADT) and immunogenic cell death (ICD) multimodal therapy in prostate cancer. Abstract Metal‐based immunotherapy represents a promising strategy for enhancing antitumor efficacy; however, its clinical application is limited
Rui Zan, Qianping Mao, Keyi Wang, Guodong Zou, Shi Yang, Hua Qiu, Xiang Fang, Guiqing Wang, Xinyi Zhou, Jiexia Wen, Shuai Jiang, Ran Huang, Qiuming Peng, Tao Suo   +13 more
wiley   +1 more source