Results 111 to 120 of about 29,420 (294)

Prevalence of OATP1B‐Mediated Drug–Drug Interactions in an Academic Medical Center

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT OATP1B is a key transporter involved in hepatic drug uptake, where its inhibition can significantly increase plasma drug levels, leading to potential adverse effects. This retrospective study aimed to determine the prevalence of potential drug–drug interactions (pDDIs) mediated by the hepatic transporter OATP1B1/3 in a cohort of 44,877 ...
Mathilde Bories, David Malnoë, Pascal Le Corre   +2 more
wiley   +1 more source

Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans

Antimicrobial Agents and Chemotherapy, 2020
Echinocandins are recommended as the first-line drugs for the treatment of systemic candidiasis. Cas5 is a key transcription factor involved in the response to cell wall damage induced by echinocandins. ABSTRACT Echinocandins are recommended as the first-
K. Xiong, C. Su, Qiangqiang Sun, Yang Lu
semanticscholar   +1 more source

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance

mBio, 2020
The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein kinase (MAPK)
Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman   +16 more
doaj   +1 more source

Prior in vitro exposure to voriconazole confers resistance to amphotericin B in aspergillus fumigatus biofilms [PDF]

, 2015
Triazoles are the mainstay of treatment for aspergillosis, although resistance to these antifungal agents may be associated with treatment failure. Refractory infections often necessitate a switch to other antifungal agents, including amphotericin B (AmB)
Jones, Brian, Mowat, Eilidh, Rajendran, Ranjith, Ramage, Gordon, Williams, Craig   +4 more
core   +1 more source

Epidemiology of Candidemia, Candiduria and Emerging Candidozyma (Candida) auris Across Gulf Cooperative Council Countries and Yemen in the Arabian Peninsula

Mycoses, Volume 68, Issue 6, June 2025.
ABSTRACT Candida infections represent a major component of invasive and non‐invasive mycoses globally, including the countries in the Arabian Peninsula. In this review, we present epidemiological features and trends, clinical manifestations, species distribution, antifungal susceptibility, and outcomes available for candidemia and candiduria in six ...
Suhail Ahmad, Teun Boekhout, Abdullah M. S. Al‐Hatmi, Ahmed Al‐Harrasi, Aiah Mustafa Khateb, Fatima Al Dhaheri, Hajer Bin Shuraym, Jens Thomsen, Khaled Alobaid, Mohammad Asadzadeh, Saad J. Taj‐Aldeen, Saleh Alwasel, Wadha Alfouzan, Ziauddin Khan, Husam Salah   +14 more
wiley   +1 more source

Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus

mBio, 2020
Aspergillus fumigatus is responsible for a wide range of diseases affecting several million people worldwide. Currently, a few families of antifungals are available to fight aspergillosis, and we are facing a worrisome increase in resistance to azoles ...
Nicolas Papon, Florent Morio, Dominique Sanglard   +2 more
doaj   +1 more source

The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi [PDF]

, 2016
Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient
Fernandes, Chantal, Gonçalves, Teresa, Gow, Neil A. R.   +2 more
core   +1 more source

Approaches to Invasive Fungal Diseases in Paediatric Cancer Centres: An Analysis of Current Practices and Challenges in Germany, Austria and Switzerland

Mycoses, Volume 68, Issue 6, June 2025.
ABSTRACT Background Invasive fungal diseases (IFD) pose significant challenges in paediatric oncology. Their management is complicated by limited paediatric‐specific evidence, lack of standardised protocols and variability in resources across centres.
Danila Seidel, Zoi Dorothea Pana, Daniel Ebrahimi‐Fakhari, Sarina K. Butzer, Katrin Mehler, Ilana Reinhold, Arne Simon, Christian Dohna‐Schwake, Ines Mack, Nicole Bodmer, Tim Niehues, Alexander Claviez, Alfred Längler, Alfred Leipold, Aram Prokop, Bastian Brummel, Beate Winkler, Bernd Gruhn, Carl Friedrich Classen, Carsten Friedrich, Christa Koenig, Christian Flotho, Fiona Poyer, Freimut Schilling, Gabriele Calaminus, Geeke Sieben, Georg C. Schwabe, Harald Reinhard, Heiko‐Manuel Teltschik, Heinz Hengartner, Jana Stursberg, Jeanette Greiner, Johann Greil, Jörg Leyh, Jörn‐Sven Kühl, Karoline Ehlert, Konrad Bochennek, Marius Rohde, Martin Demmert, Martina Stiefel, Matthias Eyrich, Meinolf Siepermann, Michael Frühwald, Michaela Döring, Michaela Nathrath, Milen Minkov, Monika Streiter, Neil Jones, Nora Naumann‐Bartsch, Norbert Jorch, Olaf Beck, Rita Beier, Roman Crazzolara, Silke Kietz, Simon Vieth, Stefan Fröhling, Stephan Lobitz, Sujal Ghosh, Tanja C. Vallée, Thilo Müller, Thomas Wiesel, Tobias Däbritz, Udo Kontny, Uwe Thiel, Volker Strenger, Wolfgang R. Eberl, Oliver A. Cornely, Andreas H. Groll, Thomas Lehrnbecher   +68 more
wiley   +1 more source

Antifungal Resistance Among Candida Species: Diagnostic and Clinical Challenges in Specialized Cancer Care Hospital of Lahore

Journal of Clinical Laboratory Analysis, Volume 39, Issue 9, May 2025.
Consumption of antifungals showed a declining trend, with the highest consumption of oral voriconazole (mean DOT/1000 pt. days 18653.49) and oral fluconazole (mean DOT/1000 pt. days 15258.14). Candida albicans was the most isolated pathogen 768 (53.60%) and among all Candida species, major resistance was found in Candida tropicalis 58 (4.05%).
Zunaira Akbar, Muhammad Aamir, Zikria Saleem, Muhammad Rehan Khan Niazi, Hasan Ejaz, Muharib Alruwaili, Khalid Abosalif   +6 more
wiley   +1 more source

Characterization of COVID‐19‐Associated Candidemia Among Burn Patients

Journal of Clinical Laboratory Analysis, Volume 39, Issue 10, May 2025.
This study investigates the distribution of Candida species isolated from burn patients with candidemia, colonization, and urinary cultures. The findings highlight the predominance of C. albicans and C. parapsilosis across different sample types, including wound colonization, blood, and urine.
Maryam Salimi, Javad Javidnia, Azam Moslemi, Mahdi Abastabar, Mohammad Reza Mobayen, Golnar Rahimzadeh, Nahid Mirzaei Tirabadi, Seyedehzahra Nouranibaladezaei, Hassan Asghari, Behnam Sobouti, Mostafa Dahmardehei, Seyedmojtaba Seyedmousavi, Tahereh Shokohi   +12 more
wiley   +1 more source