Results 71 to 80 of about 29,420 (294)
BMC Infectious Diseases, 2010 Background A prospective observational registry assessed real world experience with caspofungin monotherapy or combination therapy for the initial or salvage treatment of proven or probable invasive aspergillosis (IA).
Chandwani Sheenu +7 more
doaj +1 more source
PLoS Genetics, 2020 The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence.
Marienela Y Heredia +7 more
doaj +1 more source
Utilization and comparative effectiveness of caspofungin and voriconazole early after market approval in the U.S. [PDF]
PLoS ONE, 2014 Both caspofungin and voriconazole were initially approved by the FDA with very narrow indications. Our aim was to evaluate the utilization patterns and comparative effectiveness of these agents early after marketing before any labeling change occurred ...
Sibel Ascioglu, K Arnold Chan
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of response (CFR) for ...
Qianting Yang +13 more
doaj +1 more source
Efficacy and safety of caspofungin in obese patients [PDF]
Medical Mycology, 2011 Safety and efficacy outcomes were retrospectively compared for obese versus non-obese patients who received standard caspofungin doses for different clinical conditions in nine clinical trials within the Merck caspofungin database. Favorable outcomes were as defined in specific protocols.
Desmond M. Ryan +2 more
openaire +3 more sources
Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China
Journal of Global Antimicrobial Resistance, 2021 : Objectives: Effective antifungal therapy is important to reduce mortality in patients with invasive fungal infections (IFIs). Numerous factors affect pharmacokinetic/pharmacodynamic (PK/PD) parameters in critically-ill patients.
Fangyi Li +5 more
doaj
Drug-Resistant Candida glabrata Infection in Cancer Patients
Emerging Infectious Diseases, 2014 Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between ...
Dimitrios Farmakiotis +2 more
doaj +1 more source
Gels, 2023 Caspofungin is a drug that is used for fungal infections that are difficult to treat, including invasive aspergillosis and candidemia, as well as other forms of invasive candidiasis.
Noelia Pérez-González +8 more
doaj +1 more source
An investigation into the transcription factors and regulatory mechanisms of Aspergillus
Food Safety and Health, EarlyView.Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley +1 more source
Journal of the American Medical Association (JAMA), 2019 Importance Children, adolescents, and young adults with acute myeloid leukemia are at high risk of life-threatening invasive fungal disease with both yeasts and molds.
B. Fisher +13 more
semanticscholar +1 more source